利用人体组织液进行近红外无创血糖测量

提出了一种利用人体皮肤组织液进行近红外无创血糖检测的新方法。通过细化人体表层皮肤组织模型，将真皮层上层含有少量血液的乳突层与真皮层下层区分开，并与表皮层共同作为探测对象；选择人体表皮层较厚的腕曲侧部作为检测部位；在此基础上利用蒙特卡罗方法计算了1680 nm（葡萄糖倍频吸收峰）近红外光在人体腕曲侧部皮肤组织模型中的平均最大穿透深度、主要吸收区域、平均光程、出射能量、各层皮肤组织吸收能量占比。结果显示，当光源到探测器探头距离为0.6 mm时，真皮层和角质层吸收的能量较少，光程适中，平均探测深度、主要吸收位置均位于乳突层中，因而此距离为最佳距离，并设计了光纤探头。通过以上方式避开了富含血液的真皮层下层的干扰，获取了表皮层和乳突层中组织液的光谱信息，有利于血糖的近红外无创测量，为后续工作提供了理论依据。

Abstract

A new near-infrared noninvasive method of detecting the glucose from human skin tissue interstitial fluid is presented. The skin tissue structure is refined, and the papillary layer containing a small amount of blood separated from the lower area of the dermal layer and the surface layer are used as the main objects. The wrist curved side is selected as the detecting part. And the average probe depth, the main absorption position, the average photon path length, the outputting energy and the fraction of absorbed energy in each skin tissue layer are calculated by the Monte Carlo method based on the above. The results show that both the average probe depth and the main absorption area are located in the papillary layer. The average photon path length is long enough and less energy is absorbed by the stratum corneum and the dermis when the distance between detector and the source is 0.6 mm. Thus the optimum source-detector distance of 0.6 mm is determined and the optical fiber detector is designed. The uniqueness of the method is that the spectral information from the epidermis and papillary is captured without the interference from the rich blood containing lower dermis, which is good for the near-infrared noninvasive blood glucose detection and provides a theoretical basis for the follow-up work.

参考文献

[1] O S Khalil. Spectroscopic and clinical aspects of noninvasive glucose measurements [J]. Clinical Chemistry, 1999, 45(2): 165-177.

[2] K Maruo, M Tsurugi, M Tamura, et al.. In vivo noninvasive measurement of blood glucose by near-infrared diffuse-reflectance spectroscopy [J]. Applied Spectroscopy, 2003, 57(10): 1236-1244.

[3] 丁海泉, 卢启鹏, 彭忠琦，等. 近红外光谱技术用于无创生化检验研究的进展[J]. 光谱学与光谱分析, 2010, 30(8): 2107-2110.

Ding Haiquan, Lu Qipeng, Peng Zhongqi, et al.. Progress in noninvasive biochemical examination by near infrared spectroscopy [J]. Spectroscopy and Spectral Analysis, 2010, 30(8): 2107-2110.

[4] G W Hopkins, G R Mauze. In-vivo NIR diffuse-reflectance tissue spectroscopy of human subjects [C]. SPIE, 1999, 3597: 632-641.

[5] 丁海泉, 卢启鹏, 陈星旦. 近红外光谱无创生化检测中不定光程对模型精度的影响研究[J]. 光学学报, 2012, 32(4): 0430003.

Ding Haiquan, Lu Qipeng, Chen Xingdan. Effect of variable optical path length on the accuracy of the model in noninvasive biochemical detection by NIR spectrum [J]. Acta Optica Sinica, 2012, 32(4): 0430003.

[6] 黄富荣, 罗云瀚, 郑仕富, 等. 全血胆固醇、甘油三酯近红外光谱分析与模型优化[J]. 光学学报, 2011, 31(10): 1030001.

Huang Furong, Luo Yunhan, Zheng Shifu, et al.. Near-infrared spectroscopic analysis and model optimization on cholesterol and triglyceride in whole blood [J]. Acta Optica Sinica, 2011, 31(10): 1030001.

[7] 李晨曦, 赵会娟, 郑家祥, 等. 深度分辨漫反射测量光纤探头设计及特性[J]. 光学学报, 2012, 32(7): 0717001.

Li Chenxi, Zhao Huijuan, Zheng Jiaxiang, et al.. Design and property of depth-selective fiber-optical probes applied in diffuse reflection measurement [J]. Acta Optica Sinica, 2012, 32(7): 0717001.

[8] 张洪艳, 张来明, 陈月, 等. 近红外漫反射光谱在人体血糖无创检测中的应用[J]. 激光与红外, 2005, 35(2): 96-99.

Zhang Hongyan, Zhang Laiming, Chen Yue, et al.. Application of NIR diffusion reflectance spectrum technology in the noninvasive measurement for human blood glucose [J]. Laser & Infrared, 2005, 35(2): 96-99.

[9] J P Bantle, W Thomas. Glucose measurement in patients with diabetes mellitus with dermal interstitial fluid [J]. Journal of Laboratory and Clinical Medicine, 1997, 130(4): 436-441.

[10] E Kulcu, J A Tamada, G Reach, et al.. Physiological differences between interstitial glucose and blood glucose measured in human subjects [J]. Diabetes Care, 2003, 26(8): 2405-2409.

[11] K Rebrin, Jr N F Sheppard, G M Steil. Use of subcutaneous interstitial fluid glucose to estimate blood glucose: revisiting delay and sensor offset [J]. J Diabetes Sci Technol, 2010, 4(5): 1087-1098.

[12] T Maeda, N Arakawa, M Takahashi, et al.. Monte Carlo simulation of spectral reflectance using a multilayered skin tissue model [J]. Opt Rev, 2010, 17(3): 223-229.

[13] V V Tuchin, S R Utz, I V Yaroslavsky. Tissue optics, light distribution, and spectroscopy [J]. Opt Eng, 1994, 33(10): 3178-3188.

[14] O Kim, J McMurdy, C Lines, et al.. Reflectance spectrometry of normal and bruised human skins: experiments and modeling [J]. Physiol Meas, 2012, 33(2): 159.

[15] 王安乐, 李婷, 邓勇, 等. 基于MCVM研究真实前臂结构对光传输的影响[J]. 光学学报, 2011, 31(3): 0317002.

Wang Anle, Li Ting, Deng Yong, et al.. Influence of real forearm structure on light transport based on MCVM [J]. Acta Optica Sinica, 2011, 31(3): 0317002.

[16] 王德昌, 傅洪滨, 王一兵. 人体皮肤组织学彩色图谱 [M]. 济南: 山东科学技术出版社, 1999. 70.

Wang Dechang, Fu Hongbin, Wang Yibing. Color Atlas of Human Skin Histology [M]. Jinan: Shandong Science & Technology Press, 1999. 70.

[17] M Tarumi, M Shimada, T Murakami, et al.. Monte Carlo simulation of NIR spectrum changes induced by variations of glucose concentration [C]. SPIE, 2002, 4624: 28-35.

[18] 李晨曦, 赵会娟, 郑家祥, 等. 深度分辨漫反射测量光纤探头设计及特性[J]. 光学学报, 2012, 32(7): 0717001.

Li Chenxi, Zhao Huijuan, Zheng Jiaxiang, et al.. Design and property of depth-selective fiber-optical probes applied in diffuse reflection measurement [J]. Acta Optica Sinica, 2012, 32(7): 0717001.

[19] D J Segelstein. The Complex Refractive Index of Water [D]. Kansas: University of Missouri-Kansas City, 1981.

[20] P S Ray. Broadband complex refractive indices of ice and water [J]. Appl Opt, 1972, 11(8): 1836-1844.

[21] T L Troy, S N Thennadil. Optical properties of human skin in the near infrared wavelength range of 1000 to 2200 nm [J]. Journal of Biomedical Optics, 2001, 6(2): 167-176.

[22] K Iino, K Maruo, H Arimoto, et al.. Monte Carlo simulation of near infrared reflectance spectroscopy in the wavelength range from 1000 nm to 1900 nm [J]. Opt Rev, 2003, 10(6): 600-606.

[23] A N Bashkatov, E A Genina, V V Tuchin. Optical properties of skin, subcutaneous, and muscle tissues: a review [J]. Journal of Innovative Optical Health Sciences, 2011, 4(1): 9-38.

吴春阳, 卢启鹏, 丁海泉, 高洪智. 利用人体组织液进行近红外无创血糖测量[J]. 光学学报, 2013, 33(11): 1117001. Wu Chunyang, Lu Qipeng, Ding Haiquan, Gao Hongzhi. Noninvasive Blood Glucose Sensing with Near-Infrared Spectroscopy Based on Interstitial Fluid[J]. Acta Optica Sinica, 2013, 33(11): 1117001.

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