Early-photon guided reconstruction method for time-domain fluorescence lifetime tomography 
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1 Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China
2 Center for Biomedical Imaging Research, Tsinghua University, Beijing 100084, China
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Fig. 1. Schematic of the measurement system.
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Fig. 2. Reconstruction results of (a) and (b) Expt. 1 and (c) and (d) Expt. 2. (a) and (c) denote the inverse lifetime maps obtained by the EPFLT method, while (b) and (d) denote those obtained by the DFLT method. The red and green circles denote the phantom border and the position of fluorescence targets, respectively.
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Fig. 3. Reconstruction results of (a) and (b) Expt. 3 and (c) and (d) Expt. 4. (a) and (c) denote the inverse lifetime maps obtained by the EPFLT method, while (b) and (d) denote those obtained by the DFLT method. The red and green circles denote the phantom border and the position of fluorescence targets, respectively.
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Fig. 4. Profiles along the dashed-dotted lines in Figs. 2 and 3 for (a) Expt. 1, (b) Expt. 2, (c) Expt. 3, and (d) Expt. 4. The red lines denote the real inverse lifetime profiles, while the blue and green lines denote the inverse lifetime results obtained by the EPFLT and DFLT methods, respectively.
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Table1. Comparison of Fluorescence Lifetimes and Relative Errors by the EPFLT and DLFT Methods
| Expt. | Solvent | (ns) | (ns) | Real lifetime (ns) | (%) | (%) |
|---|
| 1 | DMSO | 0.874 | 1.068 | 0.97 | 9.9 | 10.1 | | DMSO | 0.942 | 1.037 | 0.97 | 2.9 | 6.9 | | 2 | DMSO | 0.827 | 0.843 | 0.97 | 14.7 | 13.1 | | ALC | 0.652 | 0.640 | 0.62 | 5.2 | 3.2 | | 3 | DMSO | 1.022 | 1.019 | 0.97 | 5.4 | 5.0 | | DMSO | 0.998 | 0.993 | 0.97 | 2.9 | 2.4 | | 4 | DMSO | 0.902 | 1.067 | 0.97 | 7.0 | 10.0 | | ALC | 0.672 | 0.853 | 0.62 | 8.4 | 37.5 |
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Table2. Comparisons of Contrasts and Crosstalks
| Expt. | Method | CNR | RD (%) | Real RD (%) | RC (%) |
|---|
| 1 | EPFLT | 7.37 | 7.8 | 0 | 0 | | DFLT | 2.38 | 3.0 | 0 | 46.6 | | 2 | EPFLT | 6.00 | 26.8 | 56.45 | 0 | | DFLT | 2.30 | 31.7 | 56.45 | 53.8 | | 3 | EPFLT | 4.45 | 2.4 | 0 | 0 | | DFLT | 2.65 | 2.0 | 0 | 63.5 | | 4 | EPFLT | 4.39 | 34.2 | 56.45 | 0 | | DFLT | 2.44 | 8.5 | 56.45 | 77.7 |
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Lin Zhang, Chuangjian Cai, Yanlu Lv, Jianwen Luo. Early-photon guided reconstruction method for time-domain fluorescence lifetime tomography[J]. Chinese Optics Letters, 2016, 14(7): 071702.
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