激光生物学报, 2019, 28 (5): 405, 网络出版: 2019-11-14  

LED红光在临床疾病中的研究及应用

Study and Application of Red Light-Emitting Diode (LED) in Clinical Diseases
作者单位
哈尔滨医科大学医学微生物学教研室, 哈尔滨医科大学伍连德研究所, 哈尔滨 150081
摘要
发光二极管(LED)是一种将电能转化为光能的半导体电子元件。随着LED技术的不断升级, 其应用范围也从传统的照明领域延伸扩大。近年来, LED在临床应用及基础试验研究中越来越受到人们的重视, 尤其是LED在皮肤病、关节炎、骨质疏松、伤口愈合与修复、抗感染和免疫调节等方面的研究。本文将主要对LED红光在多种临床疾病中的研究和应用进行综述。
Abstract
Light-emitting diode (LED)is a semiconductor material that converts electrical energy into light energy. With the constant upgrading of LED technology, its application range is also extended from the traditional lighting field. In recent years, LED has received more and more attention in clinical application and experimental study, especially in the areas of skin diseases, arthritis, osteoporosis, wound healing and repair, anti-infection and immune regulation. This paper mainly reviews the study and application of LED red light in different clinical diseases.
参考文献

[1] PASSARELLA S, KATU T. Absorption of monochromatic and narrow band radiation in the visible and near IR by both mitochondrial and non-mitochondrial photoacceptors results in photobiomodulation[J]. Journal of Photochemical Photobiology B: Biology, 2014, 140: 344-358.

[2] FIGUROVA M, LEDECKY V, KARASOVA M, et al. Histological assessment of a combined low-level laser/light-emitting diode therapy (685 nm/470 nm)for sutured skin incisions in a porcine model: a short report[J]. Photomedicine Laser Surgery, 2016, 34(2): 53-55.

[3] TRELLES M A, ALLONES I. Red light-emitting diode (LED)therapy accelerated wound healing post-blepharoplasty and periocular laser ablative resurfacing[J]. Journal of Cosmetic and Laser Therapy, 2006, 8(1): 39-42.

[4] WANG C Y, TSAI S C, YU M C, et al. Light-emitting diode irradiation promotes donor site wound healing of the free gingival graft[J]. Journal of Periodontology, 2015, 86(5): 674-681.

[5] BAPTISTA J, MARTINS M D, PAVESI V C, et al. Influence of laser photobiomodulation on collagen IV during skeletal muscle tissue remodeling after injury in rats[J]. Photomedicine Laser Surgery, 2011, 29(1): 11-17.

[6] BAEZ F, REILLY L R. The use of light-emitting diode therapy in the treatment of photoaged skin[J]. Journal of Cosmetic Dermatology, 2007, 6(3): 189-194.

[7] MAMALIS A, JAGDEO J. Light-emitting diode-generated red light inhibits keloid fibroblast proliferation[J]. Dermatologic Surgery, 2015, 41(1): 35-39.

[8] 霍彦明, 王志远, 封丽华. LED光源在医学中的应用[J]. 灯光与照明, 2010, 34(4): 59-62.

    HUO Yanming, WANG Zhiyuan, FENG Lihua. The applications of LED in the field of medical science[J]. Light and Lighting, 2010, 34(4): 59-62.

[9] OH C T, KWON T R, CHOI E J, et al. Inhibitory effect of 660 nm LED on melanin synthesis in in vitro and in vivo[J]. Photodermatology, Photoimmunology and Photomedicine, 2017, 33(1): 49-57.

[10] GOLDBERG D J, RUSSELL B A. Combination blue (415 nm)and red (633 nm)LED phototherapy in the treatment of mild to severeacne vulgaris[J]. Journal of Cosmetic and Laser Therapy, 2006, 8(2): 71-75.

[11] LI W H, FASSIH A, BINNER C, et al. Low-level red LED light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne[J]. Lasers Surgery Medicine, 2018, 50(2): 158-165.

[12] AMORIM J C, SOARES B M, ALVES O A. Phototoxic action of light emitting diode in the in vitro viability of Trichophyton rubrum[J]. Anais Brasileiros de Dermatologia, 2012, 87(2): 250-255.

[13] SBGHEN M R, VOLTARELLI E M, CAMPOIS T G, et al. Topical intrademal efficacy of photodynamic therapy with methylene blue and light-emitting diode in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis[J]. Journal of Lasers Medicine Sciences, 2015, 6(3): 106-111.

[14] YAMAUCHI N, TAGUCHI Y, KATO H, et al. High-power, red-light-emitting diode irradiation enhances proliferation, osteogenic differentiation, and mineralization of human periodontal ligament stem cells via ERK signaling pathway[J]. Journal of Periodontology, 2018, 89(3): 351-360.

[15] HAAG P A, STEIGER-RONAY V, SCHMIDLIN P R. The in vitro antimicrobial efficacy of PDT against periodontopathogenic bacteria[J]. International Journal of Molecular Sciences, 2015,16(11): 27327-27338.

[16] EICK S, MARKAUSKAITE G, NIETZSCHE S, et al. Effect of photoactivated disinfection with a light-emitting diode on bacterial species and biofilms associated with periodontitis and peri-implantitis[J]. Photodiagnosis and Photodynamic Therapy, 2013, 10(2): 156-167.

[17] CHANG P C, CHIEN L Y, YE Y, et al. Irradiation by light-emitting diode light as an adjunct to facilitate healing of experimental periodontitis in vivo[J]. Journal of Periodontal Research, 2013, 48(2): 135-143.

[18] SACONO N T, COSTA C A, BAGNATO V S, et al. Light-emitting diode therapy in chemotherapy-induced mucositis[J]. Lasers Surgery Medicine, 2008, 40(9): 625-633.

[19] FUJIMOTO K, KIYOSAKI T, MITSUI N, et al. Low-intensity laser irradiation stimulates mineralization via increased BMPs in MC3T3-E1 cells[J]. Lasers Surgery Medicine, 2010, 42(6): 519-526.

[20] STEIN A, BENAYAHU D, MALTZ L, et al. Low-level laser irradiation promotes proliferation and differentiation of human osteoblasts in vitro[J]. Photomedicine Laser Surgery, 2005, 23(2): 161-166.

[21] TANI A, CHELLINI F, GIANNELLI M, et al. Red (635 nm), near-infrared (808 nm)and violet-blue (405 nm)photobiomodulation potentiality on human osteoblasts and mesenchymal stromal cells: a morphological and molecular in vitro study[J]. International Journal of Molecular Sciences, 2018, 19(7): 1946.

[22] HONIG S. Osteoporosis-new treatments and updates[J]. Bulletin of the NYU Hospital for Joint Disease, 2010, 68(3): 166-170.

[23] LIM H J, BANG M S, JUNG H M, et al. A 635-nm light-emitting diode (LED)therapy inhibits bone resorptive osteoclast formation by regulating the actin cytoskeleton[J]. Lasers Medicine Sciences, 2014, 29(2): 659-670.

[24] SOHN H, KO Y, PARK M, et al. Effects of light-emitting diode irradiation on RANKL-induced osteoclastogenesis[J]. Lasers Surgery Medicine, 2015, 47(9): 745-755.

[25] ASAI T, SUZUKI H, KITAYAMA M, et al. The long-term effects of red light-emitting diode irradiation on the differentiation of osteoblast-like MC3T3-E1 cells[J]. The Kobe Journal Medicine Sciences, 2014, 60(1): 12-18.

[26] 何艳艳, 陈佳媚, 金红林. 不同剂量的LED红光直接照射对人肝癌细胞HepG2生长特性的影响[J]. 激光生物学报, 2009, 18(4): 463-478.

    HE Yanyan, CHEN Jiamei, JIN Honglin. The effect of various energy fluence low-power red LED irradiation on the growth of HepG2[J]. Acta Laser Biology Sinica, 2009, 18(4): 463-478.

[27] ZHANG L, XIONG Z, LI Z, et al. Effects of red light emitting diode on apoptosis of HeLa cells and suppression of implanted HeLa cells growth in mice[J]. Journal Radiation Research, 2009, 50(2): 109-117.

[28] SIMONE C B, CENGEL K A. Photodynamic therapy for lung cancer and malignant pleural mesothelioma[J]. Seminars Oncology, 2014, 41(6): 820-830.

[29] YUAN S X, SUN X, LI F C. The combined application of photodynamic therapy and immunotherapy in tumor treatment[J]. Chinese Journal of Clinical Neurosurgery, 2007, 12(12): 764-767.

[30] CORTI L, TONIOLO L, BOSO C, et al. Long-term survival of patients treated with photodynamic therapy for carcinoma in situ and early non-small-cell lung cancer[J]. Lasers Surgery Medicine, 2007, 39(5): 394-402.

[31] GODOY H, VADDADI P, COOPER M, et al. Photodynamic therapy effectively palliated gynecologic malignancies[J]. European Journal of Gynaecological Oncology, 2013, 34(4): 300-302.

[32] PARK I S, MONDAL A, CHUNG P S, et al. Vascular regeneration effect of adipose-derived stem cells with light-emitting diode phototherapy in ischemic tissue[J]. Lasers Medicine Sciences, 2015, 30(2): 533-541.

[33] SILVA FONSECA T H, ALACOQUE M, SILVA OLIVERIRA F M, et al. Photodynamic therapy as a new approach to trichomonas vaginalis inactivation[J]. Photodiagnosis and Photodynamic Therapy, 2018, 22: 91-95.

[34] MGGUFF P E, DETERLING R A, GOTTLIED L S. Tumoricidal effect of laser energy on experimental and human malignant tumors[J]. The New England Journal of Medicine, 1965, 273(9): 490-492.

[35] JOO H J, JEONG K H, KIM J E, et al. Various wavelengths of light-emitting diode light regulate the proliferation of human dermal papilla cells and hair follicles via Wnt/β- catenin and the extracellular signal-regulated kinase pathways[J]. Annals of Dermatology, 2017, 29(6): 747-754.

[36] VALE K L D, MARIA D A, PICOLI L C, et al. The effects of photoblomodulation delivered by light-emitting diode on stem cells from human exfoliated deciduous teeth: a study on the relevance to pluripotent stem cell viability and proliferation[J]. Photomedicine Laser Surgery, 2017, 35(12): 659-665.

魏霜, 李玉军, 张凤民. LED红光在临床疾病中的研究及应用[J]. 激光生物学报, 2019, 28(5): 405. WEI Shuang, LI Yujun, ZHANG Fengmin. Study and Application of Red Light-Emitting Diode (LED) in Clinical Diseases[J]. Acta Laser Biology Sinica, 2019, 28(5): 405.

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!