黑色素形态分布对血管性皮肤疾病激光热疗参数选取的影响

根据表皮内黑色素的产生及迁移特点，提出10种黑色素形态分布假设，采用两尺度皮肤传热模型研究黑色素形态分布、激光脉宽、病变血管尺寸和深度等参数对激光治疗葡萄酒色斑过程中表皮层和血管能量阈值的影响。结果表明,黑色素分布对表皮能量阈值影响较大，对血管无明显影响。黑色素分布越均匀，血管尺寸越小、埋藏越浅，则血管性皮肤疾病疗效越好。黑色素仅分布于表皮基底层时，应适当延长制冷剂喷雾时间。血管性皮肤疾病达最佳疗效前提下，黑色素分布越均匀、血管尺寸越大，应选取接近病变血管热弛豫时间的较长脉宽（15~20 ms）激光；血管尺寸越小，埋藏越深，皮肤激光手术中应选取较短脉宽（小于5 ms）激光。

Abstract

Ten different morphological distributions of melanin were proposed according to their formation and migration characteristics, and the two-scale skin model was applied to investigate the influence of melanin distribution, pulse duration, diameter and depth of pathological vessels on the radiant exposure thresholds of epidermis and blood vessels during the laser therapy of Port Wine Stains. The results show that distribution of melanin has a greater influence on the epidermal radiant exposure threshold, but has no obvious effect on that of blood vessels. It is conducive to cure vascular skin diseases with more uniform distribution of melanin, smaller and shallower blood vessels. Spray duration should be prolonged when melanin only distributes in the basal layer of epidermis. With optimized curative effect for vascular skin diseases, long laser pulse (15-20 ms) will be a good choice for more uniform distribution of melanin and larger blood vessels, which is close to the thermal relaxation time of pathological vessels. Shoter pulse (<5 ms) should be chosen for smaller and deeper vessels.

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尚要龙, 袁园, 李东, 陈斌. 黑色素形态分布对血管性皮肤疾病激光热疗参数选取的影响[J]. 中国激光, 2016, 43(11): 1107002. Shang Yaolong, Yuan Yuan, Li Dong, Chen Bin. Influence of Morphological Distributions of Melanin on Parameters Selection in Laser Thermotherapy for Vascular Skin Diseases[J]. Chinese Journal of Lasers, 2016, 43(11): 1107002.

黑色素形态分布对血管性皮肤疾病激光热疗参数选取的影响

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