用于皮肤荧光光谱检测的光纤探头设计

王贻坤; 张龙; 朱灵; 杨三梅; 刘勇; 王安

doi:doi:10.3788/lop48.093003

激光与光电子学进展, 2011, 48 (9): 093003, 网络出版: 2011-07-25

用于皮肤荧光光谱检测的光纤探头设计

Fiber-Optic Probe Design for Detecting Skin Fluorescence

论文大纲

王贻坤张龙朱灵 ^*杨三梅刘勇王安

作者单位

中国科学院安徽光学精密机械研究所光电子技术研究室，安徽合肥 230031

医用光学荧光光谱光纤探头设计蒙特卡罗法皮肤组织 medical optics fluorescence spectrum fiber-optic probe design Monte Carlo method skin tissue

摘要

为了提高皮肤荧光光谱的收集效率，对用于皮肤组织荧光光谱检测的光纤探头设计进行了重点研究。通过建立人体皮肤组织光学模型，并利用Monte Carlo方法模拟光在光纤探头及皮肤组织中的传播过程，研究光纤数量、光纤芯径、数值孔径、入射光纤与收集光纤近边缘距离、光纤探头与皮肤的距离等光纤探头各特性参数对荧光光谱检测的影响；设计、制作了一种光纤探头，应用于人体皮肤晚期糖基化终末(AGE)产物荧光光谱检测中，分析检测效果，并进行模拟与实验的对比研究。结果表明，较之于常规光纤探头，根据Monte Carlo模拟进行设计的光纤探头，荧光光谱检测性能有明显改进，且模拟与实验结果有一致的变化趋势，验证了通过Monte Carlo模拟进行光纤探头设计的可行性。光纤探头特性参数对皮肤荧光光谱检测有着显著影响，针对不同检测目的，设计特定的光纤探头，能够改善基于荧光光谱检测的医疗设备的性能。

Abstract

Fiber-optic probe design is studied to improve the efficacy of collection of tissue fluorescence. After optical models of human skin tissue is developed, Monte Carlo method is employed to simulate light propagation in fiber-optic probe and skin tissue, and to investigate the effect of fiber-optic probe parameters, including number of fibers, fiber diameter, numerical aperture, source-collection fiber separation distance, fiber-tissue spacer thickness, on light propagation and fluorescence collection. Then, a fiber-optic probe is designed to detect fluorescence of human skin advanced glycation end (AGE) products, the performance of the probe is analysed, and comparison between simulation and experiment was carried out. Results indicate that, compared with a common fiber-optic probe, the designed probe has better ability to collect fluorescence and decrease reflected light of skin tissue. In addition, the consistency of experiment and simulation result indicates that Monte Carlo method can be used in the design of fiber-optic probe. Fiber-optic probe parameters can affect light propagation and fluorescence detection obviously. Designing different fiber-optic probes according to different application purposes, can improve its efficacy of fluorescence based diagnostic devices.

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王贻坤, 张龙, 朱灵, 杨三梅, 刘勇, 王安. 用于皮肤荧光光谱检测的光纤探头设计[J]. 激光与光电子学进展, 2011, 48(9): 093003. Wang Yikun, Zhang Long, Zhu Ling, Yang Sanmei, Liu Yong, Wang An. Fiber-Optic Probe Design for Detecting Skin Fluorescence[J]. Laser & Optoelectronics Progress, 2011, 48(9): 093003.

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