一种基于稳态光子计数模式的面向乳腺扩散荧光光学联合层析成像方法

易茜; 武林会; 王欣; 陈玮婷; 张丽敏; 赵会娟; 高峰

doi:doi:10.3724/sp.j.1010.2014.00318

红外与毫米波学报, 2014, 33 (3): 318, 网络出版: 2014-06-30

一种基于稳态光子计数模式的面向乳腺扩散荧光光学联合层析成像方法

A combined diffuse fluorescence and optical tomography of steady-state photon-counting mode for breast tumor diagnosis

论文大纲

易茜 ^1,*武林会 ¹王欣 ¹陈玮婷 ¹张丽敏 ^1,2赵会娟 ^1,2高峰 ^1,2

作者单位

¹ 天津大学精密仪器与光电子工程学院，天津300072

² 天津市生物医学检测技术和仪器重点实验室，天津300072

摘要

为增强乳腺扩散光学层析(Diffuse Optical Tomography, DOT)方法的实用性，提出了一套稳态扩散荧光光学联合断层成像系统与算法.系统采用基于光开关切换的串并混合门控光子计数检测模式，可有效实现测量时间、灵敏度和系统性价比之间的平衡；算法以图形处理器加速的蒙特卡洛光子输运模型为基础，采用了荧光DOT“导航”的血氧DOT图像重建策略，通过利用高对比度荧光DOT的先验位置信息，可有效改善血氧DOT图像重建的不适定性.仿体实验结果表明，与单独DOT方法相比，此联合方法可明显提高图像重建的定位准确度和定量性.

Abstract

A combined fluorescence-optical tomography methodology of steady-state is developed to enhance the applicability of the breast-dedicated diffuse optical tomography (DOT). The system employed a 4-channel gated photon-counting technique working in a fiber-switch-based tandem series-to-parallel mode to achieve the tradeoff among the measuring time, probing sensitivity and cost effectiveness. Based on the graphics-processing-unit accelerated Monte Carlo modeling of photon migration, a fluorescence-guided hemoglobin DOT reconstruction algorithm was proposed, which can effectively alleviate the ill-posedness of the hemoglobin DOT using the localization prior provided by the high-contrast fluorescence DOT. The phantom experiments demonstrate that the reconstruction accuracy and quantitative performance can be improved efficiently comparing with the standalone-DOT.

参考文献

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易茜, 武林会, 王欣, 陈玮婷, 张丽敏, 赵会娟, 高峰. 一种基于稳态光子计数模式的面向乳腺扩散荧光光学联合层析成像方法[J]. 红外与毫米波学报, 2014, 33(3): 318. YI Xi, WU Lin-Hui, WANG Xin, CHEN Wei-Ting, ZHANG Li-Min, ZHAO Hui-Juan, GAO Feng. A combined diffuse fluorescence and optical tomography of steady-state photon-counting mode for breast tumor diagnosis[J]. Journal of Infrared and Millimeter Waves, 2014, 33(3): 318.

一种基于稳态光子计数模式的面向乳腺扩散荧光光学联合层析成像方法

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