光学与光电技术, 2018, 16 (6): 63, 网络出版: 2018-12-17   

婴幼儿视网膜广域成像关键技术研究

Study on Key Techniques of Wide-Area Retinal Imaging for Infant
作者单位
南京航空航天大学机电学院 数字医疗装备实验室, 江苏 南京 210016
摘要
为解决眼底相机在进行视网膜疾病筛查时视场角较小的问题,设计了一种基于角膜接触眼底镜、利用多环光纤实现广域照明的视网膜广域成像系统。对该系统所采用的眼模型、广域成像及照明方式等进行了研究。首先,为实现系统充分照明,设计了多环光纤照明结构;接着为模拟人眼广域成像原理,结合婴幼儿眼球结构特点建立了Escudero-Sanz大视场眼模型;然后设计了角膜接触眼底镜,采用像差小、折射率大的非球面设计,满足大视场的要求;最后搭建了实验平台。实验结果表明:设计的角膜接触眼底镜可以实现85°视场的广域成像,采用多环光纤光线照明可以得到较清晰的视网膜及其周边血管图像。
Abstract
In order to solve the shortcomings of the fundus camera in the retinal disease screening, the retinal wide-area imaging system based on corneal contact ophthalmoscope and wide-area illumination using multi-ring fiber is designed. The eye model, wide angel imaging, and illumination methods etc. adopted by the system are investigated. First, in order to achieve full illumination of the system, a multi-ring fiber optic illumination structure is designed. In order to simulate the principle of wide angle imaging of human eyes, the Escudero-Sanz large field of view model is established based on the characteristics of infant eyeball structure. Then, a corneal contact ophthalmoscope is designed, which adopts aspherical design with small aberration and large refractive index to meet the requirements of large field of view. Finally, the construction of the experimental platform is built. The experimental results indicate that the retinal imaging system has a full field of view of 85°. A corneal contact ophthalmoscope can be used to achieve wide angle imaging of fundus retina images.
参考文献

[1] 蒋春秀. 新生儿眼病筛查应用进展(续)[J]. 中国斜视与小儿眼科杂志, 2015, 23(1): 44-45.

    JIANG Chun-xiu. Progress in screening for neonatal eye diseases (continued) [J]. Chinese Journal of Strabismus and Pediatric Ophthalmology. 2015, 23(1): 44-45.

[2] 许立华. 早产儿及低体质量儿视网膜病变发病率及相关危险因素研究分析[J]. 中国实用医刊, 2017, 44(7): 98-101.

    XU Li-hua. Incidence and risk factors of premature and low birth weight infant[J]. Chinese Journal of Practical Medicine. 2017, 44(7): 98-101.

[3] 李谐, 邹海东, 汪枫桦, 等. 改进制作的高光谱免散瞳眼底照相机在眼底病患者临床初步应用研究[J]. 中华眼底病杂志, 2012, 28(5):485-488.

    Li Xie, Zou Haidong, Wang Fenghua, et al. The processing of hyperspectral non mydriatic fundus camera application study [J]. Chinese Journal of Ocular Fundus Diseases, 2012, 28(5):485-488.

[4] 陈艳武. 新型眼底成像机构研究[D]. 长春: 长春理工大学, 2013.

    CHEN Wu-yan. Study on mechanism of new fundus imaging[D]. Changchun: Changchun University of Science and Technology, 2013.

[5] 马晨. 便携式眼底相机光学系统的设计方法研究[D]. 北京: 北京理工大学, 2014.

    MA Chen. Research on Optical Design Method for Portable Fundus Camera[D]. Beijing: Beijing Institute of Technology, 2014.

[6] 李灿. 新型眼底相机的研制[D]. 长春: 中国科学院长春光学精密机械与物理研究所. 2014.

    LI Can. Design and fabrication of new type of fundus camera[D]. Changchun: Changchun Institute of Optics, Fine Mechanics and Physics Chinese Academy of Sciences. 2014.

[7] 王植. 广域数字眼底成像关键技术研究[D]. 南京: 南京航空航天大学, 2017.

    WANG Zhi. Research on key technique of wide-area digital fundus imaging technology[D]. Nanjing: Nanjing University of Aeronautics and Astronautics. 2017.

[8] 李灿, 宋淑梅, 刘英, 等. 折反式眼底相机光学系统设计[J]. 光学精密工程, 2012, 20(8):1710-1717.

    LI Can, SONG Shu-mei, LIU Ying, et al. Design of optical system for catadioptric fundus camera[J]. Optics and Precision Engineering. 2012, 20(8): 1710-1717.

[9] 杨家强, 程德文, 王庆丰, 等. 新型大视场消杂光眼底相机光学系统的设计[J]. 光学学报, 2012, 32(11): 1-7.

    YANG Jia-qiang, CHENG De-wen, WANG Qing-fneg, et al. Design of a novel view-field angle and anti-stray-light fundus camera[J]. Acta Optica Sinica, 2012, 32(11): 1-7.

[10] 王梦蝶. 眼底相机立体成像系统的光路设计方法研究[D]. 天津: 天津工业大学, 2017.

    WANG Meng-die. Research on optical path design method of fundus camera stereo imaging system[D]. Tianjin: Tianjin Polytechnic University, 2017.

[11] Shaoze Wang, Kai Jin, Haitong Lu, et al. Human visual system-based fundus image quality assessment of portable fundus camera photographs [J]. Senior Member, IEEE. 2016, 35(4): 1046-1056.

[12] Khalil Ghasemi Falavarjani, Irena Tsui, Srinivas R Sadda. Ultra-wide-field imaging in diabetic retinopathy [J]. Journal of Corrent Ophthalmology, 2016, 28(2): 57-60.

[13] Isabel Escudero-Sanz, Rafael Navarro. Off-axis aberrations of a wide-angle schematic eye model[J]. Optical Society of America, 1999, 16(8): 1881-1891.

[14] 孔梅梅, 高志山, 陈磊, 等. 人眼光学模型的研究与发展[J]. 激光技术, 2008, 32(4): 370-373.

    KONG Mei-mei, GAO Zhi-shan, CHEN Lei. Research and development of human eye optical model[J]. Laser technology, 2008, 32(4): 370-373.

[15] 迟泽英, 陈文建. 应用光学与光学设计基础[M]. 南京: 东南大学出版社. 2008.

    CHI Ze-ying, CHEN Wen-jian. Applied optics and elements of optical design[M]. Nianjing: Southeast University Press, 2008.

[16] 国家食品药品监督管理局. 眼科仪器 眼底照相机: YY 0634-2008 [S]. 北京:中国标准出版社, 2009.

    State Food and Drug Administration. Ophthalmic Instruments-Fundus Cameras: YY 0634-2008 [S]. Beijing: China Standard Press, 2009.

[17] 中华人民共和国国家质量监督检验检疫总局, 中国国家标准化管理委员会. 灯和灯系统的光生物安全性: GB/T 20145-2006/CIE S 009/E: 2002 [S]. 北京:中国标准出版社, 2006.

    General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China, China National Standardization Administration. Photobiosafety of lamps and lamp systems: GB/T 20145-2006/CIE S 009/E: 2002 [S]. Beijing: China Standard Press, 2006.

姚凤莹, 沈建新, 陈华. 婴幼儿视网膜广域成像关键技术研究[J]. 光学与光电技术, 2018, 16(6): 63. YAO Feng-ying, SHEN Jian-xin, CHEN Hua. Study on Key Techniques of Wide-Area Retinal Imaging for Infant[J]. OPTICS & OPTOELECTRONIC TECHNOLOGY, 2018, 16(6): 63.

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