激光与光电子学进展, 2024, 61 (6): 0618017, 网络出版: 2024-03-22
微观探索的新光芒:便携式光声显微成像技术(特邀)特邀综述
New Light in Microscopic Exploration: Portable Photoacoustic Microscopy (Invited)
生物医学成像 光声成像 光声显微成像 便携式光声显微成像 biomedical imaging photoacoustic imaging photoacoustic microscopy portable photoacoustic microscopy
摘要
光声成像(PAI)是一种结合了光学成像高对比度和超声成像深穿透性的生物医学成像模态,近年来得到了迅速发展。其中,光声显微成像(PAM)作为光声成像的重要实现方式之一,可以在毫米级的成像深度上实现微米级甚至百纳米级的分辨率,能够实现对生物组织结构、功能和分子的高分辨率成像,已在临床诊断、皮肤病检测和眼科等领域得到广泛应用。首先对PAM的工作原理和实现方式等进行基本介绍,之后围绕便携式PAM技术,从手持与半手持式、脑部可穿戴式及集成多模态3方面对其研究进展进行综述,随后探讨便携式PAM技术面临的挑战,最后进行总结与展望。
Abstract
Photoacoustic imaging (PAI), a biomedical imaging mode that combines the high contrast of optical imaging with the deep penetration of ultrasonic imaging, has developed rapidly in recent years. Among them, photoacoustic microscopy (PAM), as one of the important implementation methods of photoacoustic imaging, can achieve micron-level or even hundreds of nanometer-level resolution on the millimeter imaging depth, and can achieve high-resolution imaging of biological tissue structure, function, and molecules, and has been widely used in clinical diagnosis, skin disease detection, ophthalmology, and other fields. In this paper, the working principle and implementation of PAM are first introduced, and then the research progress of portable PAM technology is reviewed from the handheld and semi-handheld, brain wearable, and integrated multi-mode. Then, the challenges faced by the portable PAM technology are discussed, and finally the prospects are summarized.
孙明丽, 李驰野, 陈睿黾, 施钧辉. 微观探索的新光芒:便携式光声显微成像技术(特邀)[J]. 激光与光电子学进展, 2024, 61(6): 0618017. Mingli Sun, Chiye Li, Ruimin Chen, Junhui Shi. New Light in Microscopic Exploration: Portable Photoacoustic Microscopy (Invited)[J]. Laser & Optoelectronics Progress, 2024, 61(6): 0618017.