肝脏和肺组织的太赫兹光谱成像

马品; 杨玉平; 范丽洁; 陈根祥

doi:doi:10.11805/tkyda201606.0838

太赫兹科学与电子信息学报, 2016, 14 (6): 838, 网络出版: 2017-01-23

肝脏和肺组织的太赫兹光谱成像

Terahertz spectrum and imaging of liver and lung tissues

论文大纲

马品 ^*杨玉平范丽洁陈根祥

作者单位

中央民族大学理学院, 北京 100081

太赫兹光谱太赫兹成像肝脏肺 terahertz spectrum terahertz imaging liver lung

摘要

与红外辐射、X射线、核磁共振、超声波等传统医疗诊断技术相比, 太赫兹技术具有能量低、空间分辨力高和带宽宽等独特分析能力, 成为人体成像或人体组织癌症诊断技术的补充技术。分别对肝脏和肺的正常组织与肿瘤组织做了太赫兹光谱检测与太赫兹成像研究, 通过肝脏的光谱检测与成像实验总结出相关经验, 使得肺癌组织太赫兹成像得到了明显的效果, 并且发现肺癌肿瘤组织在1.0 THz~1.75 THz频率范围内的太赫兹成像能够明显区分出正常组织与肿瘤组织, 且频率越高, 成像分辨力越高。

Abstract

Compared with traditional medical diagnostic technologies, infrared radiation, X-rays, nuclear magnetic resonance and ultrasound, etc, terahertz technology has become the complementary technology of human imaging or human tissue cancer diagnosis due to its low energy, high spatial resolution and unique analysis ability. Using Terahertz-Time Domain Spectrum(THz-TDS) and terahertz imaging technology, the normal and tumor tissues of the liver and lung are imaged respectively. Based on the relevant experiences from the terahertz spectral detection and imaging measurements of liver, significant results about the terahertz imaging of lung cancer tissue in the range of 1.0 THz-1.75 THz are obtained. The normal and tumor tissues can be clearly distinguished by the point-to-point terahertz pulse imaging; and the higher the selected frequency within the range, the higher imaging resolution can be achieved.

参考文献

[1] BOWMAN T C,El-SHENAWEE M,CAMPBELL L K. Terahertz imaging of excised breast tumor tissue on paraffin sections[J]. IEEE Transactions on Antennas & Propagation, 2015,63(5):2088-2097.

[2] WAHAIA F,KASALYNAS I,VENCKEVICIUS R,et al. Terahertz absorption and reflection imaging of carcinoma-affected colon tissues embedded in paraffin[J]. Journal of Molecular Structure, 2016(1107):214-219.

[3] WALLACE V P. Terahertz pulse imaging in reflection geometry of skin tissue using time-domain analysis techniques[J]. Proceedings of SPIE-The International Society for Optical Engineering, 2002(4625):160-169.

[4] PICKWELL E,FITZGERALD A J,COLE B E,et al. Simulating the response of terahertz radiation to basal cell carcinoma using ex vivo spectroscopy measurements[J]. Journal of Biomedical Optics, 2005,10(6):064021.

[5] WALLACE V P,PICKWELL E. Terahertz pulsed imaging of cancers[C]// Biomedical Optics 2003. [S.l.]:International Society for Optics and Photonics, 2003:353-359.

[6] FITZGERALD A J,WALLACE V P,PYE R,et al. Terahertz imaging of breast cancer, a feasibility study[C]// 2004 and 12th International Conference on Terahertz Electronics, Infrared and Millimeter Waves. [S.l.]:IEEE, 2004:823-824.

[7] GLOBUS T,WOOLARD D. Terahertz spectroscopic characterization of cancer cells[J]. Proceedings of SPIE-The International Society for Optical Engineering, 2005(5692):233-240.

[8] BRUN M A,FORMANEK F,YASUDA A,et al. Terahertz imaging applied to cancer diagnosis[J]. Physics in Medicine & Biology, 2010,55(16):4615-4623.

[9] YU C,FAN S,SUN Y,et al. The potential of terahertz imaging for cancer diagnosis: a review of investigations to date[J]. Quantitative Imaging in Medicine & Surgery, 2012,2(1):33-45.

[10] OH S J,KANG J,MAENG I,et al. Nanoparticle-enabled terahertz imaging for cancer diagnosis[J]. Optics Express, 2009, 17(5):3469-3475.

[11] FITZGERALD A J,WALLACE V P,JIMENEZLINAN M,et al. Terahertz pulsed imaging of human breast tumors[J]. Radiology, 2006,239(2):533-540.

[12] HUANG S Y,WANG Y D,AHUJA A,et al. Tissue characterization using terahertz pulsed imaging in reflection geometry[J]. Physics in Medicine & Biology, 2009,54(1):149-160.

[13] STANLEY Sy,HUANG S,WANG Y X,et al. Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast[J]. Physics in Medicine & Biology, 2010,55(24):7587-7596.

[14] SIEGEL P H. Terahertz pioneers a series of interviews with significant contributors to terahertz science and technology[J]. IEEE Transactions on Terahertz Science & Technology, 2015,5(4):529-530.

[15] YANG Yuping,LEI Xiangyun,YUE Ai,et al. Temperature-dependent THz vibrational spectra of clenbuterol hydrochloride[J]. Science China Physics Mechanics & Astronomy, 2013,56(4):713-717.

[16] 张振伟,崔伟丽 ,张岩,等. 太赫兹成像技术的实验研究 [J]. 红外与毫米波学报, 2006,25(3):217-220.(ZHANG Zhenwei,CUI Weili,ZHANG Yan,et al. Terahertz time-domain spectroscopy imaging[J]. Journal of Infrared and Millimeter Waves, 2006,25(3):217-220.)

马品, 杨玉平, 范丽洁, 陈根祥. 肝脏和肺组织的太赫兹光谱成像[J]. 太赫兹科学与电子信息学报, 2016, 14(6): 838. MA Pin, YANG Yuping, FAN Lijie, CHEN Genxiang. Terahertz spectrum and imaging of liver and lung tissues[J]. Journal of terahertz science and electronic information technology, 2016, 14(6): 838.

肝脏和肺组织的太赫兹光谱成像

关于本站 Cookie 的使用提示

全站搜索

肝脏和肺组织的太赫兹光谱成像

相关论文

相关资讯

关于本站 Cookie 的使用提示

全站搜索