Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles

Xingya Jiang; Bujie Du; Mengxiao Yu; Xun Jia; Jie Zheng

doi:doi:10.1142/s1793545816420037

Journal of Innovative Optical Health Sciences, 2016, 9 (4): 1642003, Published Online: Dec. 27, 2018

Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles

论文大纲

Xingya Jiang ¹Bujie Du ¹Mengxiao Yu ¹Xun Jia ^2,*Jie Zheng ¹

Author Affiliations

¹ Department of Chemistry and Biochemistry The University of Texas at Dallas 800 W. Campbell Rd., Richardson, TX 75080, USA

² Department of Radiation Oncology The University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard, Dallas, TX 75390, USA

Gold nanoparticles surface-ligand cell uptake radiosensitizer radiation-protecting

Abstract

Gold nanoparticles (AuNPs) could serve as potential radiotherapy sensitizers because of their exceptional biocompatibility and high-Z material nature; however, since in vitro and in vivo behaviors of AuNPs are determined not only by their particle size but also by their surface chemistries, whether surface ligands can affect their radiosensitization has seldom been investigated in the radiosensitization of AuNPs. By conducting head-to-head comparison on radiosensitization of two kinds of ultrasmall (~2 nm) near-infrared (NIR) emitting AuNPs that are coated with zwitterionic glutathione and neutral polyethylene glycol (PEG) ligands, respectively, we found that zwitterionic glutathione coated AuNPs (GS-AuNPs) can reduce survival rates of MCF-7 cells under irradiation of clinically used megavoltage photon beam at low dosage of ~2:25 Gy. On the other hand, PEG-AuNPs can serve as a radiation-protecting agent and enabled MCF-7 cells more resistant to the irradiation, clearly indicating the key role of surface chemistry in radiosensitization of AuNPs. More detailed studies suggested that such difference was independent of cellular uptake and its efficiency, but might be related to the ligand-induced difference in photoelectron generation and/or interactions between AuNPs and X-ray triggered reactive oxygen species (ROS).

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Xingya Jiang, Bujie Du, Mengxiao Yu, Xun Jia, Jie Zheng. Surface-ligand effect on radiosensitization of ultrasmall luminescent gold nanoparticles[J]. Journal of Innovative Optical Health Sciences, 2016, 9(4): 1642003.

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