中国激光, 2005, 32 (6): 864, 网络出版: 2006-06-06   

鲜红斑痣光动力治疗的模型仿真初步研究

Modeling and Simulation of the Acting Factors on Vascular Selectivity of Photodynamic Therapy
作者单位
1 北京理工大学自动控制系,北京 100081
2 中国人民解放军总医院激光科,北京 100853
摘要
为了研究光敏剂特性对光动力疗法(PDT)治疗鲜红斑痣(PWS)疗效的影响,帮助临床采取有效的治疗方案,建立了光动力治疗鲜红斑痣的数学模型。建立了卟啉类光敏剂受光激发产生单线态氧的数学模型以及光敏剂自身漂白过程和组织中扩散过程的数学模型,以国产光敏剂血啉甲醚(HMME)的实验数据为例,用蒙特卡罗方法仿真组织中的光分布,应用建立的单线态氧产生过程的数学模型,仿真光动力治疗鲜红斑痣过程中,组织内单线态氧产量的分布。对比不同的光敏剂漂白速度对组织中单线态氧产量的影响,发现漂白速率越快,破坏血管的同时对表皮和真皮组织的保护作用越好。这些结果为光动力疗法治疗鲜红斑痣的临床应用提供了具有针对性的指导。
Abstract
Photodynamic therapy (PDT) based on topical application of photosensitizers has been under development over last years. Typical application of photodynamic therapy is treatment of port wine stain (PWS). The dosimetry for topically administered photosensitizers must take an inhomogeneous drug distribution into account together with the conventional parameters such as optical scattering, absorption, and photobleaching. To study the acting factors on vascular selectivity of photodynamic therapy, the mathematic modeling of vascular selectivity of photodynamic therapy was achieved. The singlet oxygen distributions in tissue were simulated with Monte Carlo simulated light distribution. Effect of different photobleaching velocity was discussed. The simulated results indicated that faster photobleaching velocity was helpful to protect the epidermis and dermis. These results were useful for the application of photodynamic therapy in treatment of port wine stain.
参考文献

[1] Luo Ronghui, Chen Xiangcai, Liu Wanhua et al.. Injurious and immune effect of photodynamic therapy on mice bearing louis lung cancer [J]. Chinese J. Lasers, 2002, A29(8): 763~765
罗荣辉,陈香才,刘婉华 等. 光动力疗法对Louis肺癌鼠的杀伤及免疫效应 [J]. 中国激光, 2002, A29(8): 763~765

[2] . Svaasand, Pius Wyss, Marie-therese Wyss et al.. Dosimetry model for photodynamic therapy with topically administered photosensitizers[J]. Lasers in Surgery and Medicine, 1996, 18: 139-149.

[3] . Nichols, Thomas H. Foster. The mechanism of photofrin photobleaching and its consequences for photodynamic dosimetry[J]. Photochemistry and Photobiology, 1997, 65(1): 135-144.

[4] . Lucassen, Wim Verkruysse, Marleen Keijzer et al.. Light distributions in a port wine stain model containing multiple cylindrical and curved blood vessels[J]. Lasers in Surgery and Medicine, 1996, 18: 345-357.

[5] Shusen Xie, Hui Li, Buhong Lu. Measurement of optical penetration depth and refractive index of human tissue [J]. Chin. Opt. Lett., 2003, 1(1): 44~46

[6] Wang Jiangang, Wang Guiying, Xu Zhizhan. Monte Carlo simulations for time characteristics of light propagation in scattering medium [J]. Acta Optica Sinica, 2001, 21(2): 155~157
王建岗,王桂英,徐至展. 散射介质中光传输行为时间特性的蒙特卡洛模拟研究 [J]. 光学学报, 2001, 21(2): 155~157

[7] Lai Jiancheng, Li Zhenhua, Wang Chunyong et al.. Angular distribution of backscattered light from locally pathological tissues irradiated by pencil light [J]. Acta Optica Sinica, 2003, 23(11): 1403~1408
来建成, 李振华,王春勇 等. 线光束照射下局部病变组织背散射场角分布研究 [J]. 光学学报, 2003, 23(11): 1403~1408

[8] . Pickering, Johan F. Beek et al.. Modelling the effect of wavelength on the pulsed dye laser treatment of port wine stains[J]. Appl. Opt., 1993, 32(4): 393-398.

[9] . G. Nichols, T. H. Foster. Oxygen diffusion and reaction kinetics in the photodynamic therapy of multicell tumor speroids[J]. Phys. Med. Biol., 1994, 39: 2161-2181.

[10] Chen Wenhui, Yu Jianxin, Yao Jianzhong et al.. Pharmacokinetic studies on hematoporphyrin monomethyl ether: A new promising drug for photodynamic therapy of tumors [J]. Chin. J. Laser Med. Surg., 2000, 9(2): 105~108
陈文晖,余建鑫,姚建忠 等. 光动力治癌药血啉甲醚的药代动力学研究 [J]. 中国激光医学杂志, 2000, 9(2): 105~108

[11] Li Buhong, Xie Shushen, Lu Zhukang et al.. Photobleaching properties for hematoporphyrin monomethyl ether [J]. Chin. J. Laser. Med. Surg., 2001, 10(3): 151~155
李步洪,谢树森,陆祖康 等. 血啉甲醚的光漂白特性 [J]. 中国激光医学杂志, 2001, 10(3): 151~155

[12] . Redmond. Photophysical and photosensitizing properties of benzoporphyrin derivative monoacid ring A (BPD-MA)[J]. Photochemistry and Photobiology, 1994, 59(3): 328-335.

[13] Liu Fanguang, Gu Ying, Yu Changqing et al.. Effect of photosensitizer photobleaching on vascular selectivity of photodynamic therapy [J]. Chin. J. Laser Med. Surg., 2002, 11(3): 137~140
刘凡光,顾瑛,于常青 等. 光敏剂漂白特性在鲜红斑痣光动力治疗中的作用 [J]. 中国激光医学杂志, 2002, 11(3): 137~140

程刚, 钟秋海, 刘凡光, 黄乃艳. 鲜红斑痣光动力治疗的模型仿真初步研究[J]. 中国激光, 2005, 32(6): 864. 程刚, 钟秋海, 刘凡光, 黄乃艳. Modeling and Simulation of the Acting Factors on Vascular Selectivity of Photodynamic Therapy[J]. Chinese Journal of Lasers, 2005, 32(6): 864.

本文已被 6 篇论文引用
被引统计数据来源于中国光学期刊网
引用该论文: TXT   |   EndNote

相关论文

加载中...

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!