Treatment of malignant brain tumors continues to challenge scientists and clinicians alike. Location of these tumors within the central nervous system (CNS), which is considered a \privileged" organ, can prevent the penetration of chemotherapeutic agents through the blood– brain barrier (BBB). To overcome this limitation, nanoparticles are taken up and transported by macrophage and then delivered directly into the CNS. In this study, we used macrophage to uptake the folate-targeted bifunctional micelles loaded with near-infrared (NIR) dye ICG-Der-01 and investigate the dynamic bio-distributions of macrophage after intravenous injection into tumor-bearing mice. In vitro cellular experiments by confocal microscopy indicated that the uptake of micelles in macrophage was greatly enhanced due to the folate receptor overexpression. Dynamic bio-distributions of macrophage showed a rapid clearing rate through the liver intestine pathway. In conclusion, macrophage could potentially be used as nanoparticle drug carriers and require further investigation.

综合运用动态光散射光谱、 荧光光谱和高效液相-紫外光谱法检测钙离子对酪蛋白胶束结构的影响。 外源添加的钙离子的浓度从0增加至12 mmol·L-1的过程中, 酪蛋白胶束的外源ANS荧光强度和浊度一直增大, 但是其体积平均直径和胶束的多分散指数是一直下降。 同时, 当外源添加的钙螯合剂（柠檬酸根）离子的浓度从0 增加至12 mmol·L-1的过程中, 酪蛋白胶束的外源ANS荧光强度和浊度一直减小, 但是酪蛋白胶束的体积平均直径、 胶束的多分散指数和胶束的稳定性是增大的。 因此, 在对酪蛋白胶束的结构影响方面, 钙离子和柠檬酸根离起到了相反的作用。 研究证实, 外源钙离子可以有效地调节酪蛋白胶束的结构, 进而改善其功能特性。