光散射学报, 2011, 23 (1): 57, 网络出版: 2014-04-09
Raman光谱法与经典方法验证阿司匹林固体分散体
To Verify Aspirin Solid Dispersion by Vibration Spectrometry and X-ray Diffraction Method
阿司匹林 固体分散体 拉曼光谱 红外光谱 X-射线衍射 aspirin solid dispersion Raman spectroscopy infrared spectroscopy X-ray diffraction
摘要
为了验证Raman光谱法验证固体分散体的可行性, 采用熔融法制备阿司匹林固体分散体, 并用Raman光谱法和经典方法(红外光谱法和X-射线衍射法)研究其分散性。三种鉴别方法得到一致的结果--阿司匹林以微晶状态分散在固体分散体中, 且拉曼光谱法简单易行、快速直接、对样品无损伤, 是一种新的理想的检查固体分散体分散性的方法。
Abstract
Aspirin solid dispersion was prepared by melt method and was verified by Raman spectrometry and the classical methods (infrared spectrometry and X-ray powder diffractometry) in order to test the feasibility of Raman spectrometry in identifying solid dispersion. The three methods obtained the same results-Aspirin was dispersed in the carrier in the state of microcrystalline. Raman spectrometry, simple, fast, direct and non-destructive, is an ideal method in examining the dispersivity of solid dispersion.
王玮, 李晓曼, 田京辉, 席欣欣, 程黎. Raman光谱法与经典方法验证阿司匹林固体分散体[J]. 光散射学报, 2011, 23(1): 57. WANG Wei, LI Xiao-man, TIAN Jing-hui, XI Xin-xin, CHENG Li. To Verify Aspirin Solid Dispersion by Vibration Spectrometry and X-ray Diffraction Method[J]. The Journal of Light Scattering, 2011, 23(1): 57.
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