Journal of Innovative Optical Health Sciences, 2017, 10 (4): 1730005, Published Online: Dec. 27, 2018  

Photoacoustic viscoelasticity imaging dedicated to mechanical characterization of biological tissues

Yujiao Shi 1,2,*Fen Yang 1,2Qian Wang 1,2
Author Affiliations
1 Ministry of Education Key Laboratory of Laser Life Science, College of Biophotonics, South China, Normal University Guangzhou, 510631, P. R. China
2 Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, P. R. China
Abstract
Since changes in mechanical properties of biological tissues are often closely related to pathology, the viscoelastic properties are important physical parameters for medical diagnosis. A photoacoustic (PA) phase-resolved method for noninvasively characterizing the biological tissue viscoelasticity has been proposed by Gao et al. [G. Gao, S. Yang, D. Xing, “Viscoelasticity imaging of biological tissues with phase-resolved photoacoustic measurement,” Opt. Lett. 36, 3341–3343 (2011)]. The mathematical relationship between the PA phase delay and the viscosity–elasticity ratio has been theoretically deduced. Moreover, systems of PA viscoelasticity (PAVE) imaging including PAVE microscopy and PAVE endoscopy were developed, and high-PA-phase contrast images reflecting the tissue viscoelasticity information have been successfully achieved. The PAVE method has been developed in tumor detection, atherosclerosis characterization and related vascular endoscopy. We reviewed the development of the PAVE technique and its applications in biomedical fields. It is believed that PAVE imaging is of great potential in both biomedical applications and clinical studies.

Yujiao Shi, Fen Yang, Qian Wang. Photoacoustic viscoelasticity imaging dedicated to mechanical characterization of biological tissues[J]. Journal of Innovative Optical Health Sciences, 2017, 10(4): 1730005.

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!