太赫兹技术用于关节软骨检测的研究进展

骨关节炎是主要由软骨组织损伤与退化引起的常见关节疾病, 是影响人类健康的重大疾病之一, 对于关节软骨组织早期病变的检测可以大大提高疾病的治愈率, 然而相关的临床诊断技术尚未发现。近年来, 太赫兹技术在医学领域日益受到关注。与传统方法相比, 太赫兹辐射能量低, 不会产生电离辐射, 可高灵敏、无损伤地对生物组织进行成像检测, 因此在关节软骨诊断方面具有较大的应用潜力。本文简要介绍了关节软骨的生理与病理情况以及目前关节软骨检测的主要方法, 重点总结了太赫兹技术应用于关节软骨检测方面的相关研究工作, 分别包括对动物与人类关节软骨的检测, 探讨了太赫兹技术在关节软骨检测中所面临的挑战与未来研究展望。

Abstract

Osteoarthritis is a common arthritis disease caused by cartilage tissue damage and degeneration, which is one of the large epidemics that affect human health. The early detection of the pathological changes of articular cartilage can greatly improve the cure rate of disease, but the relevant clinical diagnosis technology has not been developed. In recent years, the applications and researches of terahertz technology are increasingly valued and it has drawn great attention in the field of medicine. Compared with traditional methods, the terahertz radiation is low-energy and non-ionizing whose spectral-fingerprinting capability is well-known in the biological world. Meanwhile, THz technology has a great potential in diagnosis of articular cartilage early degeneration. This paper briefly introduces the physiological and pathological conditions of the articular cartilage, the current clinical techniques of articular cartilage detection. It mainly summarizes the terahertz technology used for detecting articular cartilage, including detection of animal and human cartilage respectively. At last, the challenges and development prospects of terahertz technology in articular cartilage detection are discussed.

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马宇婷, 张瑾, 施长城, 李薇, 韩晓惠, 彭晓昱, 魏东山, 杜春雷, 崔洪亮. 太赫兹技术用于关节软骨检测的研究进展[J]. 光谱学与光谱分析, 2016, 36(7): 2031. MA Yu-ting, ZHANG Jin, SHI Chang-cheng, LI Wei, HAN Xiao-hui, PENG Xiao-yu, WEI Dong-shan, DU Chun-lei, CUI Hong-liang. Current Status and Recent Advances in Research and Application of THz Technology in Articular Cartilage Detection[J]. Spectroscopy and Spectral Analysis, 2016, 36(7): 2031.

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