六通道光纤传感药物溶出度监测仪的研制及应用

药物溶出度试验是药品检验的重要项目, 在药物质量评价方面起着非常重要的作用。利用光纤传感技术可以实现药物溶出度的自动化、过程化监测。以氙灯、氘灯或卤钨灯作为荧光、紫外光及可见光的光源, 以Y型分支光纤作为光路传输介质, 紫外-可见吸收探头或荧光分子探头作为光响应器件, CCD作为检测器, 通过自编软件实现紫外-可见吸收及荧光猝灭两种模式的检测。光纤传感药物溶出度监测仪不但解决了目前离线取样分析方法耗时、耗力的缺点, 而且提供了药物溶出过程的实时信息, 为药物质量控制提供了更好的评价手段。

Abstract

The drug dissolution test is an important examination of drug testing, which plays a very important role in the drug quality assessment. Automation and proceduring monitoring of drug dissolution can be implemented by the optical fiber sensing technology. Two modes of detection of UV-Vis absorption and fluorescence quenching were established by software implementation, with xenon lamp, deuterium lamp or halogen tungsten lamp as fluorescence, UV and visible light source, branch Y type optical fiber as light path transmission medium, UV-Vis probe and fluorescence molecular probe as light response devices, and CCD as detector. Optical fiber sensing drug dissolution monitor not only solves the current problems of time-consuming, and sampling of off-line analysis, but also provides real-time information of drug dissolution process. Thus, our study may provide a better evaluation method for the drug quality control.

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姚军, 沈静, 李莉, 李新霞, 陈坚. 六通道光纤传感药物溶出度监测仪的研制及应用[J]. 光谱学与光谱分析, 2014, 34(9): 2587. YAO Jun, SHEN Jing, LI Li, LI Xin-xia, CHEN Jian. Development and Application of Six-Channel Fiber Optic Sensing Drug Dissolution Monitor[J]. Spectroscopy and Spectral Analysis, 2014, 34(9): 2587.

六通道光纤传感药物溶出度监测仪的研制及应用

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