基于拉曼光谱技术的甲状腺疾病检测的研究

黄祖芳; 戈小松; 李永增; 陈冠楠; 冯尚源; 林居强; 雷晋萍

doi:doi:10.3964/j.issn.1000-0593(2017)11-3471-04

光谱学与光谱分析, 2017, 37 (11): 3471, 网络出版: 2018-01-04

基于拉曼光谱技术的甲状腺疾病检测的研究

Diagnosis of Human Thyroid Diseases Based on Raman Spectroscopy

论文大纲

黄祖芳 ^*戈小松李永增陈冠楠冯尚源林居强雷晋萍

作者单位

医学光电科学与技术教育部重点实验室, 福建省光子技术重点实验室, 福建师范大学, 福建福州 350007

拉曼光谱甲状腺组织甲状腺激素显微成像 Raman spectroscopy Thyriod tissue Microimaging

摘要

基于光学成像与光谱技术的无损检测是生物医学光学交叉领域研究的重要发展方向。其中拉曼光谱技术可获得检测对象的生化成分的“指纹信息”, 被广泛应用于面向生物分子, 细胞以及生物组织的检测诊断研究。甲状腺疾病尤其肿瘤的临床检测往往涉及多方法和技术手段的结合, 且存在一定的诊断难度, 因此发展新的检测技术方法具有重要的意义。首先综述了拉曼光谱技术在甲状腺细胞系的单细胞拉曼光谱检测与分析, 然后介绍甲状腺病理组织和甲状腺正常组织的拉曼光谱鉴别诊断（特别介绍了本研究小组开展以银纳米粒子为增强基底的甲状腺离体组织SERS光谱研究情况）, 以及拉曼光谱技术在甲状腺激素等方面的研究概况。最后简要探讨了拉曼光谱技术在该领域的研究应用前景和发展方向。

Abstract

Non-invasive detection based on optical imaging and spectroscopy is an important development direction in the field of biomedical optics. Among which, Raman spectroscopy was widely applied for biomolecular, cellular and bio-tissue level diagnosis due to its advantage of providing biochemical “fingerprint” information of the targets being detected. The detection of thyroid disease, especially the clinical detection of thyroid tumors often involves the combination of multiple methods and techniques, and it faces some degrees of diagnostic challenge, so the development of new detection methods is of great significance. This review mainly focuses on research advances of Raman spectroscopic detection and analysis of single thyroid cells, differentiation and diagnosis between pathological thyroid tissue and normal thyroid tissue (especially our recent research work about silver nanoparticle based surface-enhanced Raman analysis and diagnosis between pathological thyroid tissue and normal thyroid tissue) and recent Raman analysis of thyroid hormones as well. The application prospect and future directions of Raman spectroscopy in this area was also briefly discussed.

参考文献

[1] WANG Li-hong, LI Mei-yan, RUAN Hong-jun, et al(王丽虹, 李梅艳, 阮宏俊, 等). Healthy Vision(健康大视野), 2013, 21(9): 262.

[2] ZHANG Bing, LI Chao, SUN Rong-hao(张兵, 李超, 孙荣昊). Chinese Journal of Clinicians(中华临床医师杂志), 2013, 5456.

[3] WANG Mei-hua(王美花). Journal of Community Medicine(社区医学杂志), 2015, 3: 84.

[4] CHEN Jia-xin(陈嘉鑫). Digest World Latest Med Inf.(世界最新医学信息文摘), 2016, 22: 143.

[5] LI Xiao-min, HUANG Zuo-liang(李小民, 黄作良). Chinese Medicine Gudie(中国医药指南), 2015, 8: 1.

[6] ZHU Qiang(朱强). Abstracts of Chinese Medicine(中国医学文摘), 2012, 27(3): 150.

[7] Smith-Bindman R, Lebda P, Feldstein V, et al. JAMA Internal Medicine, 2013, 173(19): 1788.

[8] JIANG Qian-qian(姜茜茜). Chinese Journal of Postgraduates of Medicine(中国医师进修杂志), 2012, 35(14): 70.

[9] MA Ji-zhou, DU Yong-jun, KAN Jun, et al(马纪周, 杜勇军, 撖俊, 等). Journal of Ningxia Medical College(宁夏医科大学学报), 2013, 35(10): 1157.

[10] Sharma C. Journal of the Egyptian National Cancer Institute, 2015, 27(3): 147.

[11] Lin D, Pan J, Huang H, et al. Scientific Reports, 2014, 4: 1.

[12] Chen Y, Chen G, Feng S, et al. Journal of Biomedical Optics, 2012, 17: 0670031.

[13] Feng S, Lin D, Lin J, et al. Analyst, 2013, 138: 3967.

[14] Kneipp K, Haka A, Kneipp H, et al. Applied Spectroscopy, 2002, 56(2): 150.

[15] Movasaghi Z, Rehman S, Rehman I. Applied Spectroscopy Reviews, 2007, 42(5): 493.

[16] XU Zhi-hong, HUANG Wei, LIN Duo, et al(许智宏, 黄伟, 林多, 等). Spectroscopy and Specural Analysis(光谱学与光谱分析), 2016, 36(8): 2518.

[17] Harris A, Garg M, Yang X, et al. Head & Neck Oncology, 2009, 38(1): 1.

[18] Lones M, Smith S, Harris A, et al. Discriminating Normal and Cancerous Thyroid Cell Lines Using Implicit Context Representation Cartesian Genetic Programming. Evolutionary Computation (CEC), IEEE: 2010. 1.

[19] REN Ding-ding, LI Bao-jiang(任丁丁, 李宝江). Journal of Shanxi Medical College for Continuing Education(山西职工医学院学报), 2010, 20(1): 86.

[20] Teixeira C, Bitar R, Martinho H, et al. Analyst, 2009, 134: 2361.

[21] Stiles P, Dieringer J, Shah N, et al. Annual Review of Analytical Chemistry, 2008, 1: 601.

[22] Qian X, Peng X, Ansari D, et al. Nature Biotechnology, 2008, 26: 83.

[23] Nie S, Emory S. Science, 1997, 275(5303): 1102.

[24] Barhoumi A, Zhang D, Tam F, et al. Journal of the American Chemical Society, 2008, 130(6): 5523.

[25] Han X, Zhao B, Ozaki Y. Analytical and Bioanalytical Chemistry, 2009, 394(7): 1719.

[26] Feng S, Lin J, Cheng M, et al. Applied Spectroscopy, 2009, 63(10): 1089.

[27] Lin J, Chen R, Feng S, et al. Journal of Raman Spectroscopy, 2012, 43(4): 497.

[28] Feng S, Lin D, Lin J, et al. Analyst, 2013, 138(14): 3967.

[29] Li Z, Li C, Lin D, et al. Laser Physics Letters, 2014, 11(4): 045602.

[30] Cui Y, Chen H, Hou L, et al. Analytica Chimica Acta, 2012, 738: 76.

[31] Rohr T, Cotton T, Fan N, et al. Analytical Biochemistry, 1989, 182(2): 388.

[32] Medina-Gutierrez C, Quintanar J, Frausto-Reyes C, et al. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005, 61(1-2): 87.

[33] DING Jian-hua, GAO Ze-hong, ZHANG Zhi-lin, et al(丁建华, 高泽红, 张志麟, 等). Journal of Dalian University of Technology(大连理工大学学报), 2000, 40(1): 34.

黄祖芳, 戈小松, 李永增, 陈冠楠, 冯尚源, 林居强, 雷晋萍. 基于拉曼光谱技术的甲状腺疾病检测的研究[J]. 光谱学与光谱分析, 2017, 37(11): 3471. HUANG Zu-fang, GE Xiao-song, LI Yong-zeng, CHEN Guan-nan, FENG Shang-yuan, LIN Ju-qiang, LEI Jin-ping. Diagnosis of Human Thyroid Diseases Based on Raman Spectroscopy[J]. Spectroscopy and Spectral Analysis, 2017, 37(11): 3471.

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