中国激光, 2020, 47 (2): 0207015, 网络出版: 2020-02-21
光学相干层析功能成像及脑中风研究进展 
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Advances in Functional Optical Coherence Tomography and Neuroimaging of Stroke
图 & 表
图 1. OCTA去相关值与iSNR的线性收敛关系及OCTA去相关值方差[42]。(a)OCT数据集示意图;(b)OCTA去相关值与iSNR的关系曲线,M=99, T=40,N=3960;(c) OCTA去相关值与iSNR的关系曲线,M=15,T=20,N=300;(d) OCTA去相关值与iSNR的关系曲线,M=15,T=10,N=150;(e)所有静态像素点中,标准方差与去相关均值的关系曲线;(f)所有静态像素点中,方差平方系数与平均核尺寸的关系曲线
Fig. 1. Linear convergence relationship between OCTA decorrelation and iSNR, and OCTA decorrelation variance[42]. (a) Schematic of OCT dataset; (b) linear convergence relationship between OCTA decorrelation and iSNR, M=99, T=40, N=3960; (c) linear convergence relationship between OCTA decorrelation and iSNR, M=15, T=20, N=300; (d) linear convergence relationship between OCTA decorrelation and iSNR, M=15, <
图 2. 基于深度自适应阈值和血管形态滤波的OCTA血流投影图(比例尺:400 μm)[46]。(a)采用全局阈值时,浅层的血流投影图;(b)采用全局阈值时,深层的血流投影图;(c)采用深度自适应阈值时的血流投影图;(d)采用深度自适应阈值和三维Hessian矩阵形状滤波后的血流投影图
Fig. 2. OCTA projection based on depth-adaptive threshold and vascular morphology filtering (scale: 400 μm)[46]. (a) Blood perfusion projection in the shallow layer with global threshold; (b) deep perfusion flow projection with global threshold; (c) blood perfusion projection with depth-adaptive threshold; (d) blood perfusion projection after using depth-adaptive threshold and three-dimensional Hessian matrix shape filtering
图 3. 多路复用方法在模型中的验证结果(比例尺:500 μm)。(a)组织模拟样品的OCT结构断层图像;(b)采用不同方法得到的组织模拟样品的光学衰减系数图;(c) ROI 1和ROI 2的光学衰减系数的统计分布,与图3 (b)中不同方法相对应;(d)在不同的平均核尺寸下,不同平均方法对两区域的区分能力
Fig. 3. Verification results of HDM in the phantom (scale: 500 μm). (a) OCT structural cross-section of the tissue phantom; (b) OAC of tissue phantom obtained by different methods; (c) statistical distribution of OAC of regions of interest (ROI 1 and ROI 2) , corresponding to the different methods in Fig.3 (b); (d) ability of different average methods to distinguish two regions under different average nuclear sizes
图 4. 大鼠皮层OCTA成像结果(比例尺:400 μm)[21]。(a) OCT结构断层图;(b) OCTA血流断层图;(c)三维OCTA血流造影图;(d)全部三维OCTA血流造影投影图;(e)浅层血流投影图;(f)深层血流投影图
Fig. 4. OCTA imaging results of rat cortex (scale: 400 μm)[21]. (a) OCT structural cross-section; (b) OCTA cross-section; (c) 3D OCTA angiogram; (d) OCTA projection of all depth; (e) projection of shallow blood flow; (f) projection of deep blood flow
图 5. 光栓缺血过程中血流灌注和光学衰减系数变化(比例尺:500 μm)。(a)不同时刻的血流灌注投影图及断层图;(b)各时刻对应的光学衰减系数均值投影图及断层图;(c)缺血区域和周边区域的血流灌注比;(d)缺血区域和周边区域的归一化光学衰减系数
Fig. 5. Changes in blood perfusion and OAC during photothrombosis progression (scale: 500 μm). (a) Projections and cross-sections of blood perfusion at different times; (b) average pojections and cross-sections of OAC at different times; (c) changes in blood perfusion ratio in the ischemic and peripheral areas; (d) changes in normalized OAC of ischemic and peripheral areas
图 6. 大鼠光栓中风模型中,OCTA最大强度投影图像[21]
Fig. 6. Maximum intensity projections of OCTA in the rat chronic PT stroke model[21]
图 7. 大鼠中风模型中,慢性恢复期的光学衰减系数、血流灌注及组织学对比[48]。(a) 6个代表性时刻的光学衰减系数均值投影图及光学衰减系数断层图(比例尺:500 μm);(b)各代表性时刻的OCTA血流投影图和血流断层图(比例尺:500 μm);(c)各代表性时刻的HE染色结果;(d)损伤组织中的炎症细胞;(e)光学衰减系数评估的损伤组织面积、血流灌注评估的缺血面积和组织学HE染色切片中梗死组织面积的对比
Fig. 7. Correlation of the OAC, blood perfusion, and histology in the stroke model in rats[48]. (a) Average projections of OAC and OAC cross-sections at six representative time points; (b) projections and cross-sections of OCTA blood fusion at each representative time(scale: 500 μm); (c) HE staining results at each representative time; (d) inflammatory cells in the ischemic core; (e) measurement of ischemic or damaged areas based on blood perfusion, OAC,
杨珊珊, 姚霖, 刘开元, 李鹏. 光学相干层析功能成像及脑中风研究进展[J]. 中国激光, 2020, 47(2): 0207015. Yang Shanshan, Yao Lin, Liu Kaiyuan, Li Peng. Advances in Functional Optical Coherence Tomography and Neuroimaging of Stroke[J]. Chinese Journal of Lasers, 2020, 47(2): 0207015.
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