Near-infrared spectroscopy muscle oximetry of patients with postural orthostatic tachycardia syndrome

Parvathi Kadamati; Jeffrey J.; Brendan J.; Shima Mehrvar; Gisela G.; Harry T.; Thomas C.; Mahsa Ranji

doi:doi:10.1142/s1793545818500268

Journal of Innovative Optical Health Sciences, 2018, 11 (5): 1850026, Published Online: Dec. 26, 2018

Near-infrared spectroscopy muscle oximetry of patients with postural orthostatic tachycardia syndrome

论文大纲

Parvathi Kadamati ¹Jeffrey J. ¹Brendan J. ²Shima Mehrvar ¹Gisela G. ³Harry T. ²Thomas C. ³Mahsa Ranji ^1,*

Author Affiliations

¹ Biophotonics Laboratory University of Wisconsin Milwaukee Department of Electrical Engineering and Computer Science 3200 N Cramer St., Milwaukee, WI 53211, USA

² Medical College of Wisconsin Department of Neurology 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA

³ Medical College of Wisconsin Department of Pediatries (Gastroenterology) 8701 W Waterown Plank Rd, Milwaukee, WI 53226, USA

Hemoglobin head-up tilt table oxygenation blood volume

Abstract

Postural orthostatic tachycardia syndrome (POTS) is a disabling condition characterized by orthostatic intolerance with tachycardia in the absence of drop-in blood pressure. A custom-built near-infrared spectroscopy device (NIRS) is applied to monitor the muscle oxygenation, noninvasively in patients undergoing incremental head-up tilt table (HUT). Subjects (6 POTS patients and 6 healthy controls) underwent 30 mins of 70fl on a HUT. The results showed a significant difference in deoxyhemoglobin (Hb), change-in-oxygenation (ΔO_xy) and blood volume (ΔBV) between patients and healthy controls. However, oxyhemoglobin (HbO₂) showed a significantly faster rate of change in the healthy controls during the first 10 mins of the tilt and during the recovery. This NIRS muscle oximetry tool provides quantitative measurements of blood oxygenation monitoring in diseases such as POTS.

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Parvathi Kadamati, Jeffrey J., Brendan J., Shima Mehrvar, Gisela G., Harry T., Thomas C., Mahsa Ranji. Near-infrared spectroscopy muscle oximetry of patients with postural orthostatic tachycardia syndrome[J]. Journal of Innovative Optical Health Sciences, 2018, 11(5): 1850026.

Near-infrared spectroscopy muscle oximetry of patients with postural orthostatic tachycardia syndrome

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