点阵CO2激光辅助透皮技术治疗斑秃的临床疗效评价

王怀湘; 李建明

doi:doi:10.3969/j.issn.1007-7146.2018.03.008

激光生物学报, 2018, 27 (3): 240, 网络出版: 2018-09-07

点阵CO2激光辅助透皮技术治疗斑秃的临床疗效评价

Clinical Evaluation on the Efficacy of Fractional CO2 Laser-assisted Drug Delivery Via Skin Technique in the Treatment of Alopecia Areata

论文大纲

王怀湘 ^*李建明

作者单位

火箭军总医院礼士路门诊部皮肤科, 北京 100045

CO2点阵激光斑秃米诺地尔液激光辅助药物传输 fractional CO2 laser alopecia areata minoxidil laser-assisted drug delivery

摘要

目的: 评价点阵CO2激光辅助透皮技术结合5%米诺地尔酊外用治疗斑秃的临床疗效及其对患者生活质量的影响。方法: 将46例斑秃患者随机分成观察组、对照组,每组23例。观察组患者予以点阵CO2激光治疗,每2周1次,共6次,同时外用5%米诺地尔酊,2次/d；对照组仅外用5%米诺地尔酊,用法同观察组。治疗12周后观察并比较两组患者的临床疗效、不良反应和患者生活质量指数(DLQI)评分。结果: 观察组有效率为91.30%,高于对照组的65.22%,差异有统计学意义(P＜0.05)。治疗前,两组患者DLQI评分相比,差异无统计学意义(t=-0.912,P=0.367)。组内比较,治疗后两组患者DLQI评分均较治疗前明显下降,差异有统计学意义(t=-10.42,P=0.000；t=-8.614,P=0.000)。治疗后,观察组患者DLQI评分下降较对照组更明显,差异有统计学意义(t=-2.636,P=0.012)。两组患者不良反应发生率比较,差异无统计学意义(P＞0.05)。结论: 运用点阵CO2激光辅助药物透皮传输技术配合外用5%米诺地尔酊对斑秃的治疗临床效果显著,不良反应轻微,操作简便易行安全,值得临床推广使用。

Abstract

Objective: To evaluate the clinical efficacy and the quality of life of patients with alopecia areata treated by the CO2 fractional lasers-assisted drug transdermal delivery technique combined with topical 5% minoxidil tincture. Methods: 46 cases of alopecia areata were randomly divided into the observation group and the control group, with 23 cases in each group. The observation group was treated with CO2 fractional laser treatment, 1 times every 2 weeks, a total of 6 times, at the same time with topical 5% Minoxidil Tincture, 2 times a day. In the control group, only 5% Minoxidil Tincture was used externally and the usage was the same as the observation group. After 12 weeks of treatment, the clinical efficacy, adverse reaction and dermatology life quality index (DLQI) of the two groups were observed and compared. Results: The total effective rate was 91.30% in the observation group and 65.22% in the control group, the difference was statistically significant(P<0.05). Before treatment, there was no significant difference in DLQI scores between the two groups (t=-0.912, P=0.367). After treatment, the DLQI scores were significantly lower than those before treatment (t=-10.42, P=0.000; t=-8.614, P=0.000), DLQI scores decreased significantly in the observation group compared to the control group (t=-2.6.36, P=0.012). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions: Fractional CO2 laser-assisted drug transdermal delivery technique combined with 5% Minoxidil Tincture in treatment of alopecia areata has significant clinical efficacy, mild adverse reactions, The method is simple, safe, worthy of clinical application.

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王怀湘, 李建明. 点阵CO2激光辅助透皮技术治疗斑秃的临床疗效评价[J]. 激光生物学报, 2018, 27(3): 240. WANG Huaixiang, LI Jianming. Clinical Evaluation on the Efficacy of Fractional CO2 Laser-assisted Drug Delivery Via Skin Technique in the Treatment of Alopecia Areata[J]. Acta Laser Biology Sinica, 2018, 27(3): 240.

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