[1] T. F. Massoud, S. S. Gambhir, "Molecular imaging in living subjects: Seeing fundamental biological processes in a new light," Genes Dev. 17(5), 545–580 (2003).

[2] T. F. Massoud, S. S. Gambhir, "Integrating noninvasive molecular imaging into molecular medicine: An evolving paradigm," Trends Mol. Med. 13(5), 183–191 (2007).

[3] Z. Lei et al., "Biomimetic synthesis of nanovesicles for targeted drug delivery," Sci. Bull. 63(11), 663–665 (2018).

[4] V. Ntziachristos, "Going deeper than microscopy: The optical imaging frontier in biology," Nat. Methods 7(8), 603 (2010).

[5] D. J. Brenner, E. J. Hall, "Computed tomography -an increasing source of radiation exposure," New England J. Med. 357(22), 2277–2284 (2007).

[6] S. A. Huettel, A. W. Song, G. McCarthy, Functional Magnetic Resonance Imaging, Vol. 1, Sinauer Associates Sunderland, MA (2004).

[7] C. Yang et al., "Metalla-aromatic loaded magnetic nanoparticles for MRI/photoacoustic imagingguided cancer phototherapy," J. Mater. Chem. B 6(17), 2528–2535 (2018).

[8] X. Wang et al., "Gadolinium embedded iron oxide nanoclusters as T 1–T 2 dual-modal MRI-visible vectors for safe and e±cient siRNA delivery," Nanoscale 5(17), 8098–8104 (2013).

[9] J. W. Emsley, J. Feeney, L. H. Sutcliffe, High Resolution Nuclear Magnetic Resonance Spectroscopy, Vol. 2, Elsevier (2013).

[10] S. S. Gambhir, "Molecular imaging of cancer with positron emission tomography," Nat. Rev. Cancer 2(9), 683 (2002).

[11] K. Ogawa et al., "A practical method for positiondependent Compton-scatter correction in single photon emission CT," IEEE Trans. Med. Imag. 10(3), 408–412 (1991).

[12] J.-U. Voigt, "Ultrasound molecular imaging," Methods 48(2), 92–97 (2009).

[13] C. Errico et al., "Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging," Nature 527(7579), 499 (2015).

[14] C. Li, L. V. Wang, "Photoacoustic tomography and sensing in biomedicine," Phys. Med. Biol. 54(19), R59 (2009).

[15] M. Xu, L. V. Wang, "Photoacoustic imaging in biomedicine," Rev. Sci. Instrum. 77(4), 041101 (2006).

[16] D. Grootendorst et al., "First experiences of photoacoustic imaging for detection of melanoma metastases in resected human lymph nodes," Lasers Surg. Med. 44(7), 541–549 (2012).

[17] S. Wang et al., "Recent advances in photoacoustic imaging for deep-tissue biomedical applications," Theranostics 6(13), 2394 (2016).

[18] L. V. Wang, S. Hu, "Photoacoustic tomography: In vivo imaging from organelles to organs," Science 335(6075), 1458–1462 (2012).

[19] J. Yao, L. Song, L. V. Wang, "Photoacoustic microscopy: Superdepth, superresolution, and superb contrast," IEEE Pulse 6(3), 34–37 (2015).

[20] D. Razansky et al., "Deep tissue optical and optoacoustic molecular imaging technologies for pre-clinical research and drug discovery," Current Pharm. Biotechnol. 13(4), 504–522 (2012).

[21] Y. Liu, L. Nie, X. Chen, "Photoacoustic molecular imaging: From multiscale biomedical applications towards early-stage theranostics," Trends Biotechnol. 34(5), 420–433 (2016).

[22] R. M. Weight, P. S. Dale, J. A. Viator, Detection of circulating melanoma cells in human blood using photoacoustic flowmetry, 2009 Annual Int. Conf. IEEE Engineering in Medicine and Biology Society, IEEE (2009).

[23] E. Ren et al., "Magnetosome modification: From bio-nano engineering toward nanomedicine," Adv. Therapeutics 1(6), 1800080 (2018).

[24] M. Chen et al., "Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging," Nano Res. 10(4), 1234–1248 (2017).

[25] L. Li, X. Pang, G. Liu, "Near-infrared light-triggered polymeric nanomicelles for cancer therapy and imaging," ACS Biomater. Sci. Eng. 4(6), 1928–1941 (2017).

[26] G. S. Filonov et al., "Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe," Angew. Chem. Int. Ed. 51(6), 1448–1451 (2012).

[27] J. Zhang et al., "Biocompatible D–A semiconducting polymer nanoparticle with Light-harvesting unit for highly effective photoacoustic imaging guided photothermal therapy," Adv. Funct. Mater. 27(13), 1605094 (2017).

[28] X. R. Song et al., "Co9Se8 nanoplates as a new theranostic platform for photoacoustic/magnetic resonance dual-modal-imaging-guided chemophotothermal combination therapy," Adv. Mater. 27(21), 3285–3291 (2015).

[29] J. Ye et al., "Noninvasive magnetic resonance/photoacoustic imaging for photothermal therapy response monitoring," Nanoscale 10(13), 5864–5868 (2018).

[30] X. Wang et al., "Size-controlled biocompatible silver nanoplates for contrast-enhanced intravital photoacoustic mapping of tumor vasculature," J. Biomed. Nanotechnol. 14(8), 1448–1457 (2018).

[31] Q. Fu et al., "Photoacoustic imaging: Contrast agents and their biomedical applications," Adv. Mater. 31(6), 1805875 (2019).

[32] L. V. Wang, "Prospects of photoacoustic tomography," Med. Phys. 35(12), 5758–5767 (2008).

[33] M. Chen et al., "Core–shell Pd@Au nanoplates as theranostic agents for in-vivo photoacoustic imaging, CT imaging, and photothermal therapy," Adv. Mater. 26(48), 8210–8216 (2014).

[34] J. Yao, L. V. Wang, "Recent progress in photoacoustic molecular imaging," Curr. Opin. Chem. Biol. 45, 104–112 (2018).

[35] J. H. Kang, J.-K. Chung, "Molecular-genetic imaging based on reporter gene expression," J. Nucl. Med. 49, 164S (2008).

[36] P. Ray, A. De, "Reporter gene imaging in therapy and diagnosis," Theranostics 2(4), 333 (2012).

[37] P. Brader, I. Serganova, R. G. Blasberg, "Noninvasive molecular imaging using reporter genes," J. Nucl. Med. 54(2), 167–172 (2013).

[38] C. Liu et al., "Advances in imaging techniques and genetically encoded probes for photoacoustic imaging," Theranostics 6(13), 2414–2430 (2016).

[39] L. Cheng et al., "PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy," Biomaterials 35(37), 9844–9852 (2014).

[40] K. Mishra et al., Photocontrollable Proteins for Optoacoustic Imaging, ACS Publications (2019).

[41] J. Brunker et al., "Photoacoustic imaging using genetically encoded reporters: A review," J. Biomed. Opt. 22(7), 070901 (2017).

[42] D. M. Shcherbakova et al., "Natural photoreceptors as a source of fluorescent proteins, biosensors, and optogenetic tools," Ann. Rev. Biochem. 84, 519–550 (2015).

[43] D. H. Juers, B. W. Matthews, R. E. Huber, "LacZ β-galactosidase: Structure and function of an enzyme of historical and molecular biological importance," Protein Sci. 21(12), 1792–1807 (2012).

[44] J. J. Füller et al., "Biosynthesis of violacein, structure and function of l-Tryptophan oxidase VioA from Chromobacterium violaceum," J. Biol. Chem. 291(38), 20068–20084 (2016).

[45] M. Orm€o et al., "Crystal structure of the Aequorea victoria green fluorescent protein," Science 273 (5280), 1392–1395 (1996).

[46] X. Shu et al., "Novel chromophores and buried charges control color in mFruits," Biochemistry 45(32), 9639–9647 (2006).

[47] M. C. Chan et al., "Structural characterization of a blue chromoprotein and its yellow mutant from the sea anemone Cnidopus japonicus," J. Biol. Chem. 281(49), 37813–37819 (2006).

[48] A. C. Stiel et al., "18 nm bright-state structure of the reversibly switchable fluorescent protein Dronpa guides the generation of fast switching variants," Biochem. J. 402(1), 35–42 (2007).

[49] L. Li et al., "Photoacoustic imaging of lacZ gene expression in vivo," J. Biomed. Opt. 12(2), 020504 (2007).

[50] L. Li et al., "Simultaneous imaging of a lacZmarked tumor and microvasculature morphology in vivo by dual-wavelength photoacoustic microscopy," J. Innov. Opt. Health Sci. 1(2), 207–215 (2008).

[51] X. Cai et al., "Multi-scale molecular photoacoustic tomography of gene expression," PLoS One 7(8), e43999 (2012).

[52] V. Del Marmol, F. Beermann, "Tyrosinase and related proteins in mammalian pigmentation," FEBS Lett. 381(3), 165–168 (1996).

[53] H. Zheng et al., "Tyrosinase-based Reporter gene for photoacoustic imaging of MicroRNA-9 regulated by DNA methylation in living subjects," Mol. Ther. Nucleic Acids 11, 34–40 (2018).

[54] R. J. Paproski et al., "Tyrosinase as a dual reporter gene for both photoacoustic and magnetic resonance imaging," Biomed. Opt. Exp. 2(4), 771–780 (2011).

[55] A. P. Jathoul et al., "Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinasebased genetic reporter," Nat. Photonics 9(4), 239 (2015).

[56] A. Krumholz et al., "Photoacoustic microscopy of tyrosinase reporter gene in vivo," J. Biomed. Opt. 16(8), 080503 (2011).

[57] R. J. Paproski et al., "Multi-wavelength photoacoustic imaging of inducible tyrosinase reporter gene expression in xenograft tumors," Sci. Rep. 4, 5329 (2014).

[58] R. J. Paproski et al., "Validating tyrosinase homologue melA as a photoacoustic reporter gene for imaging Escherichia coli," J. Biomed. Opt. 20(10), 106008 (2015).

[59] X. Li, "Gelatinase inhibitors: A patent review (2011–2017)," Expert Opin. Ther. Pat. 28(1), 31–46 (2018).

[60] A. Bose, G. A. Petsko, D. Eliezer, "Parkinson's disease and melanoma: Co-occurrence and mechanisms," J. Parkinson's Disease 8(3), 385–398 (2018).

[61] N. Duran et al., "Advances in Chromobacterium violaceum and properties of violacein-Its main secondary metabolite: A review," Biotechnol. Adv. 34(5), 1030–1045 (2016).

[62] Y. Jiang et al., "Violacein as a genetically-controlled, enzymatically amplified and photobleaching- resistant chromophore for optoacoustic bacterial imaging," Sci. Rep. 5, 11048 (2015).

[63] A. Chattopadhyay et al., "Chromobacterium violaceum infection: A rare but frequently fatal disease," J. Pediatric Surg. 37(1), 108–110 (2002).

[64] E. Bottieau et al., "Fatal Chromobacterium violaceum bacteraemia in rural Bandundu, Democratic Republic of the Congo," New Microbes New. Infect. 3, 21–23 (2015).

[65] V. Kothari, S. Sharma, D. Padia, "Recent research advances on Chromobacterium violaceum," Asian Pacific J. Tropical Med. 10(8), 744–752 (2017).

[66] M. Svoboda et al., "Organic anion transporting polypeptides (OATPs): Regulation of expression and function," Curr. Drug Metabolism 12(2), 139–153 (2011).

[67] M. Leonhardt et al., "Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOBDTPA: Role of human organic anion transporters," Drug Metab. Dispos. 38(7), 1024–1028 (2010).

[68] M.-R. Wu et al., "Organic anion-transporting polypeptide 1B3 as a dual reporter gene for fluorescence and magnetic resonance imaging," FASEB J. 32(3), 1705–1715 (2017).

[69] M. Li et al., "Multimodality reporter gene imaging: Construction strategies and application," Theranostics 8(11), 2954 (2018).

[70] M.-R. Wu, Y.-Y. Huang, J.-K. Hsiao, "Use of indocyanine green (ICG), a medical near infrared dye, for enhanced fluorescent imaging - comparison of organic anion transporting polypeptide 1B3 (OATP1B3) and sodium-taurocholate cotransporting polypeptide (NTCP) reporter genes," Molecules 24(12), 2295 (2019).

[71] T. Drepper et al., "Reporter proteins for in vivo fluorescence without oxygen," Nat. Biotechnol. 25(4), 443 (2007).

[72] A. S. Mishin et al., "Novel uses of fluorescent proteins," Curr. Opin. Chem. Biol. 27, 1–9 (2015).

[73] D. Razansky et al., "Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo," Nat. Photonics 3(7), 412 (2009).

[74] J. Laufer et al., "In vitro characterization of genetically expressed absorbing proteins using photoacoustic spectroscopy," Biomed. Opt. Exp. 4(11), 2477–2490 (2013).

[75] N. C. Deliolanis et al., "Deep-tissue reporter-gene imaging with fluorescence and optoacoustic tomography: A performance overview," Mol. Imag. Biol. 16(5), 652–660 (2014).

[76] B. J. Bevis, B. S. Glick, "Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed)," Nat. Biotechnol. 20(1), 83 (2002).

[77] M. Z. Lin et al., "Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals," Chem. Biol. 16(11), 1169–1179 (2009).

[78] L. Wang et al., "Evolution of new nonantibody proteins via iterative somatic hypermutation," Proc. Natl. Acad. Sci. 101(48), 16745–16749 (2004).

[79] R. L. Strack et al., "A rapidly maturing far-red derivative of DsRed-Express2 for whole-cell labeling," Biochemistry 48(35), 8279–8281 (2009).

[80] M. Liu et al., "In vivo three dimensional dual wavelength photoacoustic tomography imaging of the far red fluorescent protein E2-Crimson expressed in adult zebrafish," Biomed. Opt. Exp. 4(10), 1846–1855 (2013).

[81] A. Krumholz et al., "Multicontrast photoacoustic in vivo imaging using near-infrared fluorescent proteins," Sci. Rep. 4, 3939 (2014).

[82] N. O. Alieva et al., "Diversity and evolution of coral fluorescent proteins," PLoS One 3(7), e2680 (2008).

[83] D. M. Shcherbakova, V. V. Verkhusha, "Chromophore chemistry of fluorescent proteins controlled by light," Curr. Opin. Chem. Biol. 20, 60–68 (2014).

[84] P. Dedecker, F. C. De Schryver, J. Hofkens, "Fluorescent proteins: Shine on, you crazy diamond," J. Amer. Chem. Soc. 135(7), 2387–2402 (2013).

[85] J. Liljeruhm et al., "Engineering a palette of eukaryotic chromoproteins for bacterial synthetic biology," J. Biol. Eng. 12(1), 8 (2018).

[86] M. A. Shkrob et al., "Far-red fluorescent proteins evolved from a blue chromoprotein from Actinia equina," Biochem. J. 392(3), 649–654 (2005).

[87] A. Pettikiriarachchi et al., "Ultramarine, a chromoprotein acceptor for F€orster resonance energy transfer," PloS One 7(7), e41028 (2012).

[88] G. Gourinchas, S. Etzl, A. Winkler, "Bacteriophytochromes–from informative model systems of phytochrome function to powerful tools in cell biology," Curr. Opin. Struct. Biol. 57, 72–83 (2019).

[89] K. G. Chernov et al., "Near-infrared fluorescent proteins, biosensors, and optogenetic tools engineered from phytochromes," Chem. Rev. 117(9), 6423–6446 (2017).

[90] M. Karasev et al., "Near-Infrared Fluorescent Proteins and Their Applications," Biochemistry (Moscow) 84(1), 32–50 (2019).

[91] D. M. Shcherbakova, V. V. Verkhusha, "Near-infrared fluorescent proteins for multicolor in vivo imaging," Nat. Methods 10(8), 751 (2013).

[92] D. Yu et al., "An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging," Nat. Commun. 5, 3626 (2014).

[93] D. Yu et al., "A naturally monomeric infrared fluorescent protein for protein labeling in vivo," Nat. Methods 12(8), 763 (2015).

[94] D. M. Shcherbakova et al., "Bright monomeric near-infrared fluorescent proteins as tags and biosensors for multiscale imaging," Nat. Commun. 7, 12405 (2016).

[95] C. Yuan et al., "Near infrared fluorescent biliproteins generated from bacteriophytochrome AphB of Nostoc sp. PCC 7120," Photochem. Photobiol. Sci. 15(4), 546–553 (2016).

[96] M. E. Auldridge et al., "Structure-guided engineering enhances a phytochrome-based infrared fluorescent protein," J. Biol. Chem. 287(10), 7000–7009 (2012).

[97] D. M. Shcherbakova et al., "Near-infrared fluorescent proteins: Multiplexing and optogenetics across scales," Trends Biotechnol. 36(12), 1230–1243 (2018).

[98] L. Li et al., "Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo," Nat. Commun. 9(1), 2734 (2018).

[99] L. Li et al., In vivo photoacoustic multi-contrast imaging and detection of protein interactions using a small near-infrared photochromic protein, Photons Plus Ultrasound: Imaging and Sensing 2019, International Society for Optics and Photonics (2019).

[100] P. Vetschera et al., "Characterization of reversibly switchable fluorescent proteins in optoacoustic imaging," Anal. Chem. 90(17), 10527–10535 (2018).

[101] A. C. Stiel et al., "High-contrast imaging of reversibly switchable fluorescent proteins via temporally unmixed multispectral optoacoustic tomography," Opt. Lett. 40(3), 367–370 (2015).

[102] F. V. Subach et al., "Red fluorescent protein with reversibly photoswitchable absorbance for photochromic FRET," Chem. Biol. 17(7), 745–755 (2010).

[103] S. Pletnev et al., "A structural basis for reversible photoswitching of absorbance spectra in red fluorescent protein rsTagRFP," J. Mol. Biol. 417(3), 144–151 (2012).

[104] J. Yao et al., "Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe," Nat. Methods 13(1), 67 (2016).

[105] J. Mark et al., "Dual-wavelength 3D photoacoustic imaging of mammalian cells using a photoswitchable phytochrome reporter protein," Commun. Phys. 1(1), 3 (2018).

[106] E. Brown, J. Brunker, S. E. Bohndiek, "Photoacoustic imaging as a tool to probe the tumour microenvironment," Disease Models Mech. 12(7), dmm039636 (2019).

[107] J. Yao, L. V. Wang, "Photoacoustic brain imaging: From microscopic to macroscopic scales," Neurophotonics 1(1), 011003 (2014).

[108] P. Zhang et al., "High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo," J. Biophotonics 11(1), e201700024 (2018).