双苯氟嗪盐酸盐和苯甲酸的共晶制备和谱学分析

药物共晶是改善药物活性成分(API)的物理化学特性的新技术和新思维，具有很大的应用潜力。本实验采用研磨法制备了双苯氟嗪盐酸盐(DF-HCl)和苯甲酸的共晶，应用红外光谱(IR)、拉曼光谱(Raman)、差示扫描量热分析(DSC)、 X射线衍射(XRD)和太赫兹光谱(THz)对共晶进行了表征。结果表明: 双苯氟嗪盐酸盐与苯甲酸之间形成共晶分子，太赫兹谱的研究进一步表明两种分子之间有氢键形成。

Abstract

Pharmaceutical co-crystals can improve the chemical and physical properties of active pharmaceutical ingredient (API), which is new idea and expected to provide new stable structures. Pharmaceutical co-crystals have the potential to be much more useful in pharmaceutical products than salts, solvates or hydrates, polymorphs and stoichiometric solvates (pseudo-polymorphs). In our study, dipfluzine hydrochloride-benzoic acid co-crystal was synthesized by solid co-grinding. The samples were subjected to IR, DSC, XRD, Raman and THz spectral analysis. The results indicated that dipfluzine hydrochloride-benzoic acid complex was new phase compared with the single API and CCF. THz-TDS characterization indicated that hydrogen bond formed between API and CCF, which confirmed the formation of co-crystal.

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杨彩琴, 王静, 张振伟. 双苯氟嗪盐酸盐和苯甲酸的共晶制备和谱学分析[J]. 光谱学与光谱分析, 2011, 31(9): 2476. YANG Cai-qin, WANG Jing, ZHANG Zhen-wei. Synthesis and Spectral Characteristic of Pharmaceutical Dipfluzine Hydrochloride-Benzoic Acid Co-Crystal[J]. Spectroscopy and Spectral Analysis, 2011, 31(9): 2476.

双苯氟嗪盐酸盐和苯甲酸的共晶制备和谱学分析

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