激光生物学报, 2016, 25 (2): 97, 网络出版: 2016-07-26   

评估光动力血管损伤的光学监测技术

Optical Monitoring Techniques for Assessing Vascular Damage of Vascular Targeted Photodynamic Therapy
作者单位
1 福建师范大学医学光电科学与技术教育部重点实验室, 福建省光子技术重点实验室, 福建 福州 350007
2 中国人民解放军总医院激光医学科, 北京 100853
摘要
血管靶向光动力疗法(Vascular targeted photodynamic therapy, V-PDT)已成为临床治疗鲜红斑痣和老年黄斑变性等血管性疾病的重要方法。V-PDT通过主动或被动血管靶向的作用机制诱发系列生物响应以封闭病变血管。本文评述了V-PDT的作用机制和血管生物学响应, 重点讨论了用于评估V-PDT中血管损伤的光谱与成像技术, 并分析了这些技术的优点和局限性。最后展望了用于评估V-PDT血管损伤的光学技术发展及其应用前景。
Abstract
Vascular targeted photodynamic therapy (V-PDT) is widely utilized for the clinical treatments for port wine stain and age-related macular degeneration. Serial vascular responses through active or passive targeted mechanisms can be induced for the closure of blood vessels after V-PDT. In this review, the fundamental mechanisms of vascular responses during V-PDT will be illustrated. Furthermore, the current available optical techniques for assessing the vascular damage after V-PDT are summarized, and the advantages and limitations of each optical technique will be discussed. This review concludes with a discussion on the future demands of optical monitoring techniques for assessing vascular damage during V-PDT.
参考文献

[1] LI B, QIU Z. Fundamental studies of photodynamic therapy:recent advances in China [C]. Asia Communications and Photonics Conference 2014, Optics Society of America, 2014:AF1D.3.

[2] 林慧韫, 陈德福, 李步洪, 等. 光动力学疗法的单态氧剂量学研究进展 [J]. 激光生物学报, 2011, 20(1):134-142.

    LIN Huiyun, CHEN Defu, LI Buhong, et al. The research progress in singlet oxygen dosimetry for photodynamic therapy [J]. Acta Laser Biology Sinica, 2011, 20(1):134-142

[3] SHEN Y, LIN H, HUANG Z, et al. Indirect imaging of singlet oxygen generation from a single cell [J]. Laser Physics Letters, 2011, 8(3):232-238.

[4] CHEN B, POGUE B W, HOOPES P J, et al. Vascular and cellular targeting for photodynamic therapy [J]. Critical Reviews in Eukaryotic Gene Expression. 2006,16(4):279-305.

[5] CASTELANI A, PACE G, CONCIOLI M. Photodynamic effect of haematoporphyrin on blood microcirculation [J]. The Journal of Pathology and Bacteriology, 1963, 86(1):99-102.

[6] STAR W M, MARIJNISSEN H P, VAN DEN BERG-BLOK A E, et al. Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers [J]. Cancer Research, 1986, 46(5):2532-2540.

[7] WANG W, MORIYAMA L T, BAGNATO V S. Photodynamic therapy induced vascular damage:an overview of experimental PDT [J]. Laser Physics Letters, 2013, 10(2):023001.

[8] FINGAR V H, SIEGEL K A, WIEMAN T J, et al. The effects of thromboxane inhibitors on the microvascular and tumor response to photodynamic therapy [J]. Photochemistry and Photobiology, 1993, 58(3):393-399.

[9] REED M W R, SCHUSCHKE D A, MILLER F N. Prostanoid antagonists inhibit the response of the microcirculation to“early” photodynamic therapy [J]. Radiation Research, 1991, 127(3):292-296.

[10] MICHELASSI F, SHAHINIAN H K, FERGUSON M K. Effects of leukotrienes B4, C4, and D4 on rat mesenteric microcirculation [J]. Journal of Surgical Research, 1987, 42(5):475-482.

[11] GILISSEN M J, VAN DE MERBEL L E A, STAR W M, et al. Effect of photodynamic therapy on the endothelium-dependent relaxation of isolated rat aortas [J]. Cancer Research, 1993, 53(11):2548-2552.

[12] 李步洪, 谢树森, HUANG Zheng, 等. 光动力学疗法剂量学的研究进展 [J]. 生物化学与生物物理进展, 2009, 36(6):676-683.

    LI Buhong, XIE Shusen, HUANG Zheng, et al. Advances in photodynamic therapy dosimetry [J]. Progress in Biochemistry and Biophysics, 2009, 36(6):676-683.

[13] SHARIF S A, TAYDAS E, MAZHAR A, et al. Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology:a review [J]. British Journal of Dermatology, 2012, 167(6):1215-1223.

[14] MALLIDI S, SPRING B Q, CHANG S, et al. Optical Imaging, Photodynamic Therapy and Optically Triggered Combination Treatments [J]. Cancer Journal, 2015, 21(3):194-205.

[15] IDO K, YAMAMOTO H, KAWAMOTO C, et al. Esophageal varices obliterated by photodynamic therapy for coexisting early esophageal carcinoma [J]. Gastrointestinal Endoscopy, 1997, 45(5):420-422.

[16] 顾瑛, 丁新民, 于常青, 等. 光动力疗法 [M]. 北京:人民卫生出版社 2012.

    GU Ying, DING Xinmin, YU Changqing, et al. Photodynamic therapy [M]. Beijing:People’s Medical Publishing House Co., LTD 2012.

[17] SWANSON E A, IZATT J A, LIN C P, et al. In vivo retinal imaging by optical coherence tomography [J]. Optics Letters, 1993, 18(21):1864-1866.

[18] FERCHER A F, DREXLER W, HITZENBERGER C K , et al. Optical coherence tomography - principles and applications [J]. Reports on Progress in Physics, 2003, 66(2):239-303.

[19] GAO J, PENG X, LI P, et al. Vascular distribution imaging of dorsal skin window chamber in mouse with spectral domain optical coherence tomography [J]. Frontiers of Optoelectronics, 2015, 8(2):170-176

[20] FIALOV S, RAUSCHER S, GRGER M, et al. High resolution polarization sensitive OCT for ocular imaging in rodents[C]. Proc. SPIE, 2015, 9312:93120T.

[21] WANG L V, HU S. Photoacoustic tomography:in vivo imaging from organelles to organs [J]. Science, 2012, 335(6075):1458-1462.

[22] 徐晓辉, 李晖. 生物医学光声成像 [J]. 物理, 2008, 37(2):111-119.

    XU Xiaohui, LI Hui. Photoacoustic imaging in biomedicine [J]. Physics, 2008, 37(2):111-119.

[23] YUAN K, YUAN Y, GU Y, et al. In vivo photoacoustic imaging of model of port wine stains [J]. Journal of X-Ray Science and Technology, 2012, 20(2):249-254.

[24] RAJADHYAKSHA M, GROSSMAN M, ESTEROWITZ D, et al. In vivo confocal scanning laser microscopy of human skin:melanin provides strong contrast [J]. Journal of Investigative Dermatology, 1995, 104(6):946-952.

[25] RAJADHYAKSHA M, GONZ LEZ S, ZAVISLAN J M, et al. In vivo confocal scanning laser microscopy of human skin II:Advances in instrumentation and comparison with histology [J]. Journal of Investigative Dermatology, 1999, 113(3):293-303.

[26] VAN VEEN R L, VERKRUYSSE W, STERENBORG H J. Diffuse-reflectance spectroscopy from 500 to 1 060 nm by correction for inhomogeneously distributed absorbers [J]. Optics Letters, 2002, 27(4):246-248.

[27] RAJARAM N, GOPAL A, ZHANG X, et al. Experimental validation of the effects of microvasculature pigment packaging on in vivo diffuse reflectance spectroscopy [J]. Lasers in Surgery and Medicine, 2010, 42(7):680-688.

[28] HUANG D, SWANSON E A, LIN C P, et al. Optical coherence tomography [J]. Science, 1991, 254(5035):1178-1181.

[29] ROGERS A H, MARTIDIS A, GREENBERG P B , et al. Optical coherence tomography findings following photodynamic therapy of choroidal neovascularization [J]. American Journal of Ophthalmology, 2002, 134(4):566-576.

[30] 赵士勇, 俞信, 邱海霞, 等. 光学相干层析术用于鲜红斑痣诊断 [J]. 光谱学与光谱分析, 2010, 30(12):3347-3350.

    ZHAO Shiyong, YU Xin, QIU Haixia, et al. Imaging port wine stain by optical coherence tomography [J]. Spectroscopy and Spectral Analysis, 2010, 30(12):3347-3350.

[31] ZHAO S, GU Y, XUE P , et al. Imaging port wine stains by fiber optical coherence tomography [J]. Journal of Biomedical Optics, 2010, 15(3):036020.

[32] 宋智源, 刘英杰, 王瑞康, 等. 光声成像技术 [J]. 中国激光医学杂志, 2006, 15(2):127-128.

[33] KU G, MASLOV K, LI L, et al. Photoacoustic microscopy with 2-μm transverse resolution [J]. Journal of Biomedical Optics, 2010, 15(2):021302.

[34] VIATOR J A, AU G, PALTAUF G, et al. Clinical testing of a photoacoustic probe for port wine stain depth determination [J]. Lasers in Surgery and Medicine, 2002, 30(2):141-148.

[35] KOLKMAN R G M, MULDER M J, GLADE C P, et al. Photoacoustic imaging of port-wine stains [J]. Lasers in Surgery and Medicine, 2008, 40(3):178-182.

[36] ZHANG E, LAUFER J, PEDLEY R, et al. In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy [J]. Physics in Medicine and Biology, 2009, 54(4):1035.

[37] ZHANG H F, MASLOV K, SIVARAMAKRISHNAN M, et al. Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy [J]. Applied Physics Letters, 2007, 90(5):053901.

[38] AGHASSI D, ANDERSON R R, GONZ LEZ S. Time-sequence histologic imaging of laser-treated cherry angiomas with in vivo confocal microscopy [J]. Journal of the American Academy of Dermatology, 2000, 43(1):37-41.

[39] ASTNER S, GONZLEZ S, CUEVAS J, et al. Preliminary evaluation of benign vascular lesions using in vivo reflectance confocal microscopy [J]. Dermatologic Surgery, 2010, 36(7):1099-1110.

[40] REN J, QIAN H, XIANG L, et al. The assessment of pulsed dye laser treatment of port-wine stains with reflectance confocal microscopy [J]. Journal of Cosmetic and Laser Therapy, 2014, 16(1):21-25.

[41] FREDRIKSSON I, LARSSON M, STR MBERG T. Accuracy of vessel diameter estimated from a vessel packaging compensation in diffuse reflectance spectroscopy [C]. Proc SPIE, 2011, 8087:80871M.

[42] RIVA C, ROSS B, BENEDEK G B. Laser Doppler measurements of blood flow in capillary tubes and retinal arteries [J]. Investigative Ophthalmology, 1972, 11(11):936-944.

[43] STERN M D, LAPPE D L, BOWEN P D, et al. Continuous measurement of tissue blood flow by laser-Doppler spectroscopy [J]. American Journal of Physiology, 1977, 232(4):H441-H448.

[44] SWIONTKOWSKI M F. Laser doppler flowmetry-development and clinical application [J]. The Lowa Orthopaedic Journal, 1991, 11:119-126.

[45] CHEN Z, ZHAO Y, SRINIVAS S M, et al. Optical doppler tomography [J]. IEEE Journal of Selected Topics in Quantum Electronics, 1999, 5(4):1134-1142.

[46] LUO Z, WANG P, ZHANG A, et al. Evaluation of the microcirculation in a rabbit hemorrhagic shock model using laser doppler imaging [J]. PloS One, 2015, 10(2):e0116076.

[47] CHEN D, REN J, WANG Y, et al. Relationship between the blood perfusion values determined by laser speckle imaging and laser doppler imaging in normal skin and port wine stains [J]. Photodiagnosis and photodynamic therapy, 2016, 13(1):1-9.

[48] KRUIJT B, DE BRUIJN H S, VAN DER PLOEG-VAN DEN HEUVEL A, et al. Laser speckle imaging of dynamic changes in flow during photodynamic therapy [J]. Lasers in Medical Science, 2006, 21(4):208-212.

[49] KAZMI S M S, RICHARDS L M, SCHRANDT C J, et al. Expanding applications, accuracy, and interpretation of laser speckle contrast imaging of cerebral blood flow [J]. Journal of Cerebral Blood Flow and Metabolism, 2015, 35(7):1076-1084.

[50] NELSON J S, KELLY K M, ZHAO Y, et al. Imaging blood flow in human port-wine stain in situ and in real time using optical Doppler tomography [J]. Archives of Dermatollogy, 2001, 137(6):741-744.

[51] WESTPHAL V, YAZDANFAR S, ROLLINS A M, et al. Real-time, high velocity-resolution color Doppler optical coherence tomography [J]. Optics Letters, 2002, 27(1):34-36.

[52] YU G, FLOYD T F, DURDURAN T, et al. Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI [J]. Optics Express, 2007, 15(3):1064-1075.

[53] YU G, DURDURAN T, ZHOU C, et al. Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy [J]. Clinical Cancer Research, 2005, 11(9):3543-3552.

[54] DURDURAN T, YODH A G. Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement [J]. Neuroimage, 2014, 85(1):51-63.

[55] GONZ LEZ S, SACKSTEIN R, ANDERSON R R, et al. Real-time evidence of in vivo leukocyte trafficking in human skin by reflectance confocal microscopy [J]. Journal of Investigative Dermatology, 2001, 117(2):384-386.

[56] VERVOORTS A, ROOD H, MOSER J G, et al. Laser Doppler flowmetry in photodynamic therapy on xenotransplanted tumors [C]. Proc. SPIE, 1996, 2678:423-429.

[57] MAAR N, PEMP B, KIRCHER K, et al. Ocular haemodynamic changes after single treatment with photodynamic therapy assessed with non--invasive techniques [J]. Acta Ophthalmologica, 2009, 87(6):631-637.

[58] MOREAU-GAUDRY V V, GEISER M, ROMANET J, et al. Effects of photodynamic therapy on subfoveal blood flow in neovascular age-related macular degeneration patients [J]. Eye, 2009, 24(4):706-712.

[59] HARRISON D, ABBOT N, BECK J S, et al. A preliminary assessment of laser doppler perfusion imaging in human skin using the tuberculin reaction as a model [J]. Physiological Measurement, 1999, 14(3):241.

[60] MURRAY A, HERRICK A, KING T. Laser Doppler imaging:a developing technique for application in the rheumatic diseases [J]. Rheumatology, 2004, 43(10):1210-1218.

[61] WANG I, ANDERSSON-ENGELS S, NILSSON G, et al. Superficial blood flow following photodynamic therapy of malignant non-melanoma skin tumours measured by laser Doppler perfusion imaging [J]. British Journal of Dermatology, 1997, 136(2):184-189.

[62] CHEN B, POGUE B W, GOODWIN I A, et al. Blood flow dynamics after photodynamic therapy with verteporfin in the RIF-1 tumor [J]. Radiation Research, 2003, 160(4):452-459.

[63] ENEJDER A, AF KLINTEBERG C, WANG I, et al. Blood perfusion studies on basal cell carcinomas in conjunction with photodynamic therapy and cryotherapy employing laser-Doppler perfusion imaging [J]. Acta Dermato Venereologica, 2000, 80(1):19-23.

[64] STERN M. In vivo evaluation of microcirculation by coherent light scattering [J]. Nature, 1975, 254(5495):56-58.

[65] BOAS D A, DUNN A K. Laser speckle contrast imaging in biomedical optics [J]. Journal of Biomedical Optics, 2010, 15(1):011109.

[66] 刘谦. 激光散斑衬比成像技术及其应用的研究 [D]. 武汉: 华中科技大学, 2005.

    LIU Qian. Laser speckle contrast imaging and its biomedical applications [D]. Wuhan:Huazhong University of Science and Technology, 2005.

[67] SMITH T K, CHOI B, RAMIREZ-SAN-JUAN J C, et al. Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens [J]. Lasers in Surgery and Medicine, 2006, 38(5):532-539.

[68] MOY W J, PATEL S J, LERTSAKDADET B S, et al. Preclinical in vivo evaluation of Npe6-mediated photodynamic therapy on normal vasculature [J]. Lasers in Surgery and Medicine, 2012, 44(2):158-162.

[69] CHOI B, TAN W, JIA W, et al. The role of laser speckle imaging in port-wine stain research:Recent Advances and opportunities [J]. IEEE Journal of Selected Topics in Quantum Electronics, 2016, 22(3):6800812.

[70] 王颖, 顾瑛. 激光治疗鲜红斑痣疗效的无损评价方法 [J]. 中国激光医学杂志, 2008, 17(1):60-63.

    WANG Ying, GU Ying. Modern techniques for non-invasive detection of port wine stain therapeutic outcome:a review [J]. Chin J Laser Med Surg, 2008, 17(1):60-63.

[71] LEITGEB R A, WERKMEISTER R M, BLATTER C , et al. Doppler optical coherence tomography [J]. Progress in Retinal and Eye Research, 2014, 41:26-43.

[72] NELSON J S, KELLY K M, ZHAO Y, et al. Imaging blood flow in human port-wine stain in situ and in real time using optical Doppler tomography [J]. Archives of Dermatology, 2001, 137(6):741-744.

[73] YU L, NGUYEN E, LIU G, et al. Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model [J]. Journal of Biomedical Optics, 2010, 15(6):066006.

[74] STANDISH B A, JIN X, SMOLEN J, et al. Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions [J]. Journal of Biomedical Optics, 2007, 12(3):034022.

[75] YU G. Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring [J]. Journal of Biomedical Optics, 2012, 17(1):010901.

[76] MARRERO A, BECKER T, SUNAR U, et al. Aminolevulinic acid-photodynamic therapy combined with topically applied vascular disrupting agent vadimezan leads to enhanced antitumor responses [J]. Photochemistry and Photobiology, 2011, 87(4):910-919.

[77] SUNAR U, ROHRBACH D, RIGUAL N, et al. Monitoring photobleaching and hemodynamic responses to HPPH-mediated photodynamic therapy of head and neck cancer:a case report [J]. Optics Express, 2010, 18(14):14969-14978.

[78] BECKER T L, PAQUETTE A D, KEYMEL K R, et al. Monitoring blood flow responses during topical ALA-PDT [J]. Biomedical Optics Express, 2011, 2(1):123-130.

[79] BIRCHLER M, VITI F, ZARDI L, et al. Selective targeting and photocoagulation of ocular angiogenesis mediated by a phage-derived human antibody fragment [J]. Nature Biotechnology, 1999, 17(10):984-988.

[80] ZHENG G, CHEN J, STEFFLOVA K, et al. Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation [J]. Proceedings of the National Academy of Sciences, 2007, 104(21):8989-8994.

[81] LI B, LIN L, LIN H, et al. Photosensitized single oxygen generation and detection: Recent edvances and future perspectives in cancer photodynamic therapy [J].Journal of Biophotonics, 2016:10.1002/jbio.201600055.

林黎升, 陈德福, 顾瑛, 谢树森, 李步洪. 评估光动力血管损伤的光学监测技术[J]. 激光生物学报, 2016, 25(2): 97. LIN Lisheng, CHEN Defu, GU Ying, XIE Shusen, LI Buhong. Optical Monitoring Techniques for Assessing Vascular Damage of Vascular Targeted Photodynamic Therapy[J]. Acta Laser Biology Sinica, 2016, 25(2): 97.

本文已被 1 篇论文引用
被引统计数据来源于中国光学期刊网
引用该论文: TXT   |   EndNote

相关论文

加载中...

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!