中国激光, 2020, 47 (10): 1007001, 网络出版: 2020-10-09
基于光声温度精准调控的光热治疗方法 
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Photothermal Therapy Method Based on Precise Regulation of Photoacoustic Temperature
图 & 表
图 3. 光热治疗系统的光源部分。(a)光路整体图;(b)脉冲激光器;(c)连续型激光器
Fig. 3. Light source of PTT system. (a) Overall optical path; (b) pulse laser; (c) continuous laser
图 4. 一体化探头。(a)探头侧视图;(b)探头出光口侧图;(c)一体化探头的三维模型
Fig. 4. Integrated probe. (a) Lateral view of the probe; (b) light exit of the probe; (c) 3D model of the integrated probe
图 6. 实验仿体实物图。(a)仿体侧视图;(b)仿体俯视图;(c)对照变量
Fig. 6. Physical map of experimental phantom. (a) Side view of the phantom; (b) top view of the phantom; (c) the control variable
图 8. 各组仿体光声信号与温度的线性关系。(a) 1号对照组;(b) 2号对照组;(c) 3号对照组;(d) 4号对照组;(e) 5号对照组;(f) 6号对照组
Fig. 8. Linear relationship between temperature and photoacoustic signal of each phantom. (a) Control group 1; (b) control group 2; (c) control group 3; (d) control group 4; (e) control group 5; (f) control group 6
图 11. 不同温度下的光声图像及采样信号。(a) 31 ℃,光声图像;(b) 36 ℃,光声图像;(c) 41 ℃,光声图像;(d) 41 ℃,光声信号;(e) 36 ℃,光声信号;(f) 31 ℃,光声信号
Fig. 11. Photoacoustic images and sampling signals at different temperatures. (a) Photoacoustic image at 31 ℃; (b) photoacoustic image at 36 ℃; (c) photoacoustic image at 41 ℃; (d) photoacoustic signal at 41 ℃; (e) photoacoustic signal at 36 ℃; (f) photoacoustic signal at 31 ℃
图 12. 光声图像矩阵中强度值的分布曲线
Fig. 12. Distribution curve of intensity values in photoacoustic image matrix
图 13. 仿体光声测量数据与温度的线性拟合结果。(a)光声温度敏感点;(b)平均像素值
Fig. 13. Linear fitting result between photoacoustic data and actual temperature of phantom. (a) Sensitive point of photoacoustic temperature; (b) average pixel value
图 14. 多模态重建结果。(a)光声图像;(b)超声图像;(c)温度图像
Fig. 14. Multimodal reconstruction. (a) Photoacoustic image; (b) ultrasound image; (c) temperature distribution image
表 1仿体参数
Table1. Parameters of phantom
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表 2两种测温方式的温度控制精度
Table2. Temperature control accuracy of two temperature measurement methods
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马一鸣, 马立勇, 秦泽政, 孙明健. 基于光声温度精准调控的光热治疗方法[J]. 中国激光, 2020, 47(10): 1007001. Ma Yiming, Ma Liyong, Qin Zezheng, Sun Mingjian. Photothermal Therapy Method Based on Precise Regulation of Photoacoustic Temperature[J]. Chinese Journal of Lasers, 2020, 47(10): 1007001.
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