激光联用环磷酰胺对荷瘤鼠外周血IgG影响的实验研究

黄保续; 王洪斌; 刘焕奇; 曲志娜; 刘西锋; 程绍辉; 高利

中国激光, 2004, 31 (3): 377, 网络出版: 2006-06-12

激光联用环磷酰胺对荷瘤鼠外周血IgG影响的实验研究

Study on the Effects of He-Ne Laser Irradiation Combined with Cyclophosphamide on Peripheral Blood Serum IgG in Mice Inoculated with S180 Ascites Sarcoma

论文大纲

黄保续 ^1,*王洪斌 ¹刘焕奇 ¹曲志娜 ²刘西锋 ¹程绍辉 ¹高利 ¹

作者单位

¹ 东北农业大学动物医学院,黑龙江哈尔滨 150030

² 农业部动物检疫所,山东青岛 266032

摘要

以小鼠S180腹水瘤为动物实验模型,对氦氖激光照射与化疗药物环磷酰胺(CYT)联合应用对S180荷瘤鼠外周血IgG含量影响作了系统性研究.应用11.00, 14.67和22.00 J/cm2三种剂量氦氖激光照射荷瘤鼠内眼角,同时联合应用化疗药物环磷酰胺,动态监测S180荷瘤鼠外周血IgG含量的变化.结果表明,CYT联合应用氦氖激光照射组IgG含量均高于单纯应用CYT组.

Abstract

Systematic experiments on the effects of He-Ne laser irradiation combined with the traditional antitumor medicine of cyclophosphamide on peripheral blood serum IgG were conducted by using the experimental model of mouse S180 ascites sarcoma. Three groups of tumor bearing mice were irradiated upon the inner corners with the dosages of 11 00, 14 67 and 22 00 J/cm 2 He-Ne laser irradiation respectively, and injected with CYT intraperitoneally to observe the changes of peripheral blood serum IgG in tumor bearing mice. The values of peripheral blood serum IgG in tumor bearing mice in the mice with CYT+He-Ne laser irradiation treatment were higher than that with CYT treatment only. The kinetic detection of peripheral blood serum IgG indicated that CYT showed the immunosuppressive effects on the tumor bearing mice, and the immunosuppressive effects were alleviated in some degree by He-Ne laser irradiation.

参考文献

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黄保续, 王洪斌, 刘焕奇, 曲志娜, 刘西锋, 程绍辉, 高利. 激光联用环磷酰胺对荷瘤鼠外周血IgG影响的实验研究[J]. 中国激光, 2004, 31(3): 377. 黄保续, 王洪斌, 刘焕奇, 曲志娜, 刘西锋, 程绍辉, 高利. Study on the Effects of He-Ne Laser Irradiation Combined with Cyclophosphamide on Peripheral Blood Serum IgG in Mice Inoculated with S180 Ascites Sarcoma[J]. Chinese Journal of Lasers, 2004, 31(3): 377.

激光联用环磷酰胺对荷瘤鼠外周血IgG影响的实验研究

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