表面增强拉曼光谱技术在毒品检测中的应用

卢树华; 王照明; 田方

doi:doi:10.3788/LOP55.030004

激光与光电子学进展, 2018, 55 (3): 030004, 网络出版: 2018-09-10

表面增强拉曼光谱技术在毒品检测中的应用下载： 2126次

Application of Illegal Drugs Detection Based on Surface Enhanced Raman Spectroscopy

卢树华 ^1,2,*王照明 ¹田方 ¹

作者单位

¹ 中国人民公安大学信息技术与网络安全学院, 北京 102623

² 中国人民公安大学安全防范技术与风险评估公安部重点实验室, 北京 102623

图 & 表

图 1. 几类常见毒品的分子结构式

Fig. 1. Molecular structure of several common illegal drugs

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图 2. 微流体装置和SERS联通探测唾液中毒品的原理图。(a) Ag悬浮颗粒、唾液、盐溶液通过真空抽运加载进微流体装置;(b)在流动聚焦结处样品流被侧流包围,扩散驱动层流之间的侧向质量输运;(c) Ag纳米颗粒、分析物、盐溶液在通道内自左向右流动示意图[5]

Fig. 2. Combination of microfluidic device and SERS for detection of drugs in saliva. (a) Ag nanoparticle suspension, saliva, and salt solution are loaded into microfluidic device by vacuum pump; (b) sample stream is enveloped by side-streams at flow-focusing junction and diffusion drives lateral mass transport between laminar flows; (c) schematic of Ag nanoparticles, analyte, and salt solution are introduced to the channel from the left and flow toward the right[5]

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图 3. (a) Ag纳米颗粒自聚集成球形Ag胶体超结构原理图;(b) SERS平台检测位于3D胶体超结构间隙的分析物原理图[11]

Fig. 3. (a) Schematic of self-assembly of Ag NPs into spherical Ag colloidal superstructures; (b) schematic of SERS platform for sensing analytes located in 3D geometrical gaps of colloidal superstructure[11]

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图 4. 尿液中毒品检测比较示意图。(a)标准检测程序;(b) D-SERS和SVM联用方法[6]

Fig. 4. Comparison of drugs detection in urine. (a) Standard detection procedure; (b) combination of D-SERS and SVM[6]

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图 5. 3种质量分数分别为3×10-5、3×10-6、4×10-7的MAMP毒品滥用者尿液的SERS光谱空间分布(点线为有无MAMP成分尿液的分界线)[6]

Fig. 5. Space distribution of SERS spectra of three kinds of drug abusers'urine samples containing MAMP mass fraction of 3×10-5, 3×10-6, and 4×10-7 (dotted line represents boundary of urine with or without MAMP)[6]

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表 1文献报道的毒品的SERS检测参数

Table1. SERS detection parameters of illegal drugs reported in literatures

^aDrug	^bSubstrate	Wavelength oflaser /nm	LOD	Ramanshift /cm^-1	Reference
Cocaine	Au or Ag sol-gels	785	5×10^-11	999	[31]
Cocaine	Fused Au colloids	785	50 μg·L^-1(in saliva)	999,1018,1107,1578,1593	[32]
Cocaine HCl	Metastable Ag NPs	514.5	10^-8 mol·L^-1	860,1006,1275,1450,1594	[33]
Codeine	Ag NPs	633	0.7 μmol·L^-1 (in water),1.39 μmol·L^-1(in plasma)	637,771,1131,1281,1684,2953,3028,3031,3059	[8]
BZE	Au dotted magnetic NCs	785	2.9×10^-11 (in saliva)	996,1020	[13]
Ketamine HCl	Ag nanoneedles	633	2.7×10^-11	458,593,654,1023,1048,1156,1450,1593,1721	[7]
BZE	Ag-coated CNTs	785	1 nmol·L^-1	764,812,866,968,1031,1313,1440,1581	[14]
MDMA	AgNPs	785	<5×10^-5	716,772,812,1252	[15]
Morphine	Ag sols	785	1.5 μg·L^-1	401,451,492,557,647,720,807,872,953,1032,1093,1129,1190,1248,1273,1331,1424,1467,1572	[34]
MA	UC@SiO₂@Ag	785	10^-7 mol·L^-1	1002,1030,1206	[17]
MAMP/AMP	Ag nanorods	785	50 μg·L^-1	619,742,824,997,1027,1202	[19]
AMP	R/E Ag foil	647	1.9×10^-5	998,1055,1125,1205,1223,1389,1569	[28]
MAMP	R/E Ag foil	647	1.7×10^-5	1000,1058,1126,1219,1389,572	[28]
MAMP	3D Ag superstructures	532	10^-12 (in aqueous),10^-11 ( in urine)	620,750,834,1001,1206,620,1001,1205,1030,834	[11]
MAMP	Ag NPs with MFD	633	10 nmol·L^-1	1004,1030,1219,1600	[5]
Mephedrone	Ag NPs	633	1.6 mg·L^-1	797,969,1034,1184,1212,1356,1606,1678,2922,3059	[35]
α-HAD	Ag/Au core/shell	830	0.29 mg·L^-1	686,1000,1158,1304,1595	[4]
Butalbital	Ag/Au core/shell	830	0.26 mg·L^-1	500,617,645,841,925,1040,1140,1300,1410,1642, 1726,1746	[4]
BZE	Ag/Au core/shell	830	0.09 mg·L^-1	650,1000,1020,1595,1650,1715,1730	[4]
PDE	Ag/Au core/shell	830	0.39 mg·L^-1	618,753,834,910,1002,1025,1173,1208,1334,1390,1462,1603	[4]
JWH-018	Au NPs	785	18 μg·L^-1	-	[18]
JWH-073	Au NPs	785	51 μg·L^-1	-	[18]
JWH-081	Au NPs	785	18 μg·L^-1	-	[18]
JWH-122	Au NPs	785	42 μg·L^-1	-	[18]

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卢树华, 王照明, 田方. 表面增强拉曼光谱技术在毒品检测中的应用[J]. 激光与光电子学进展, 2018, 55(3): 030004. Shuhua Lu, Zhaoming Wang, Fang Tian. Application of Illegal Drugs Detection Based on Surface Enhanced Raman Spectroscopy[J]. Laser & Optoelectronics Progress, 2018, 55(3): 030004.

表面增强拉曼光谱技术在毒品检测中的应用下载： 2126次

图 1. 几类常见毒品的分子结构式

Fig. 1. Molecular structure of several common illegal drugs

图 3. (a) Ag纳米颗粒自聚集成球形Ag胶体超结构原理图;(b) SERS平台检测位于3D胶体超结构间隙的分析物原理图[11]

Fig. 3. (a) Schematic of self-assembly of Ag NPs into spherical Ag colloidal superstructures; (b) schematic of SERS platform for sensing analytes located in 3D geometrical gaps of colloidal superstructure[11]

图 4. 尿液中毒品检测比较示意图。(a)标准检测程序;(b) D-SERS和SVM联用方法[6]

Fig. 4. Comparison of drugs detection in urine. (a) Standard detection procedure; (b) combination of D-SERS and SVM[6]

图 5. 3种质量分数分别为3×10-5、3×10-6、4×10-7的MAMP毒品滥用者尿液的SERS光谱空间分布(点线为有无MAMP成分尿液的分界线)[6]

Fig. 5. Space distribution of SERS spectra of three kinds of drug abusers'urine samples containing MAMP mass fraction of 3×10-5, 3×10-6, and 4×10-7 (dotted line represents boundary of urine with or without MAMP)[6]

表 1文献报道的毒品的SERS检测参数

Table1. SERS detection parameters of illegal drugs reported in literatures

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表面增强拉曼光谱技术在毒品检测中的应用 下载： 2126次

图 1. 几类常见毒品的分子结构式

Fig. 1. Molecular structure of several common illegal drugs

图 3. (a) Ag纳米颗粒自聚集成球形Ag胶体超结构原理图;(b) SERS平台检测位于3D胶体超结构间隙的分析物原理图[11]

Fig. 3. (a) Schematic of self-assembly of Ag NPs into spherical Ag colloidal superstructures; (b) schematic of SERS platform for sensing analytes located in 3D geometrical gaps of colloidal superstructure[11]

图 4. 尿液中毒品检测比较示意图。(a)标准检测程序;(b) D-SERS和SVM联用方法[6]

Fig. 4. Comparison of drugs detection in urine. (a) Standard detection procedure; (b) combination of D-SERS and SVM[6]

图 5. 3种质量分数分别为3×10-5、3×10-6、4×10-7的MAMP毒品滥用者尿液的SERS光谱空间分布(点线为有无MAMP成分尿液的分界线)[6]

Fig. 5. Space distribution of SERS spectra of three kinds of drug abusers'urine samples containing MAMP mass fraction of 3×10-5, 3×10-6, and 4×10-7 (dotted line represents boundary of urine with or without MAMP)[6]

表 1文献报道的毒品的SERS检测参数

Table1. SERS detection parameters of illegal drugs reported in literatures

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