中国激光, 2018, 45 (3): 0307004, 网络出版: 2018-03-06
光响应纳米基因载体的研究进展 下载: 1383次特邀综述
Research Progress of Photo-Responsive Nano-Carrier for Gene
医用光学 光响应纳米基因载体 基因控制释放 紫外-可见光 近红外光 medical optics photo-responsive nano-carrier for gene controlled release of gene ultraviolet-visible light near infrared light
摘要
光响应纳米基因载体可借外界光源实现基因的定时、定点释放,已逐渐成为非病毒基因载体研究的热点。根据响应光波长的不同,可将光响应纳米基因载体分为紫外/可见光响应的纳米基因载体和近红外光响应的纳米基因载体。综述了这两类载体材料当前的研究进展,阐述了其响应机理和释放过程,并总结了光响应纳米基因载体在构建过程中亟待解决的问题。
Abstract
Photo-responsive nano-carriers for gene can realize the release of gene at a given time and a given position by external light, and have attracted much interest as non-viral gene carriers. According to different response wavelengths, photo-responsive nano-carriers for gene can be divided into ultraviolet-visible light responsive nano-carrier for gene and near infrared light responsive nano-carrier for gene. We review the recent advances of the two nano-carriers for gene and discuss the responsive mechanisms and release processes. At last, we summarize the problems to be solved in the construction progress of photo-responsive nano-carriers for gene.
李炯, 刘小龙, 吴名. 光响应纳米基因载体的研究进展[J]. 中国激光, 2018, 45(3): 0307004. Li Jiong, Liu Xiaolong, Wu Ming. Research Progress of Photo-Responsive Nano-Carrier for Gene[J]. Chinese Journal of Lasers, 2018, 45(3): 0307004.