中国激光, 2018, 45 (3): 0307004, 网络出版: 2018-03-06
光响应纳米基因载体的研究进展 
下载： 1386次特邀综述
Research Progress of Photo-Responsive Nano-Carrier for Gene
图 & 表
图 1. 用于形成阴阳离子液胞的表面活性剂。(a) AZO TAB;(b) SDBS;(c) SDS[21]
Fig. 1. Surfactants used to form catanionic vesicles. (a) AZO TAB; (b) SDBS; (c) SDS[21]
图 3. P(AAm-co-VDT-co-SPAA)水凝胶的分子结构[26]
Fig. 3. Molecular structure of P(AAm-co-VDT-co-SPAA) hydrogels[26]
图 4. (a) UV单独作用以及UV和Fc共同作用下βCD释放DNA;(b) UV和Fc协同调控βCD和AuNP的组合分子释放DNA[23]
Fig. 4. (a) Disassembly of βCD/AZO complex irradiated by UV light and Fc competitive unsheathing; (b) corresponding target DNA released from βCD/AZO upon UV light and Fc addition[23]
图 5. (a)(2-硝基-1,3-亚苯基)双(亚甲基)二丙烯酸酯的合成;(b)具有光响应特性的PBAEs(P1-P16)以及各种带电侧基基团的分子结构[42]
Fig. 5. (a) Synthesis of (2-nitro-1,3-phenylene) bis (methylene) diacrylate; (b) library of photo-responsive PBAEs (P1-P16) and various side charged groups[42]
图 7. PDMNBLG-r-PVBLG-8/DNA复合物的细胞内动力学[44]
Fig. 7. Intracellular kinetics of PDMNBLG-r-PVBLG- 8/DNA complexes[44]
图 8. 细胞中的EGFP-GNR缀合物在NIR激光下发生形态转化释放EGFP基因[51]
Fig. 8. Release of EGFP DNA caused by shape transformation of EGFP-GNR conjugates in cells irradiated by NIR laser[51]
图 9. 不同NIR激发下金纳米棒缀合DNA的选择性释放[52]
Fig. 9. Selective release of DNA-conjugated nanorods under different NIR irradiation[52]
图 10. (a) DMNPE固化的质粒DNA和siRNA在NIR光上转换为UV光的激发下释放;(b)固定后的质粒DNA/siRNA载入UCNs的介孔[56]
Fig. 10. (a) Plasmid DNA and siRNA caged by DMNPE are released by upconverted UV light from NIR light; (b) loading of caged plasmid DNA/siRNA into mesopores of UCNs[56]
图 11. (a) Si-UCNPs的合成过程;(b)吸附于颗粒表面的DNA/siRNA在上转换UV光的激发下释放[57]
Fig. 11. (a) Synthesis processes of Si-UCNPs;(b) DNA/siRNA adsorbed on particle surface are released by upconverted UV light[57]
图 12. Alkyl-PEI2k-Cdots/siRNA复合物的形成及其被递送到癌细胞的过程[59]
Fig. 12. Formation of Alkyl-PEI2k-Cdots/siRNA complex and progress of being delivered into cancer cell[59]
图 13. (a) 2-硝基苄基两亲嵌段共聚物的化学结构和光解;(b)内含物的光控释放[60]
Fig. 13. (a) Chemical structure and photolysis of 2-nitrobenzyl-containing amphiphilic block copolymer; (b) photo-controlled release of an encapsulated agent[60]
李炯, 刘小龙, 吴名. 光响应纳米基因载体的研究进展[J]. 中国激光, 2018, 45(3): 0307004. Li Jiong, Liu Xiaolong, Wu Ming. Research Progress of Photo-Responsive Nano-Carrier for Gene[J]. Chinese Journal of Lasers, 2018, 45(3): 0307004.
PDF全文
