中国激光, 2013, 40 (7): 0714003, 网络出版: 2013-07-01   

基于马赫-曾德尔结构的相差表面等离子体共振传感器

Phase Difference Surface Plasmon Resonance Sensor Based on Mach-Zehnder Configuration
作者单位
1 南开大学信息技术科学学院现代光学研究所, 天津 300071
2 南开大学人民医院, 天津 300121
摘要
研究了一种基于马赫-曾德尔结构的相差表面等离子体共振(SPR)传感器系统。和传统的相位型SPR传感系统相比,该系统采用了p偏振光与s偏振光各自干涉后再相位相减来提取样品折射率信息的方法,从而显著降低了环境噪声的影响,提高了分辨率。系统最小可区分0.01°的相差,对应的分辨率为10-5RIU(折射率单位)。应用此系统进行了生物大分子结合反应的测量,分辨率可达每平方微米160个IgG分子。研究结果为表面等离子体共振传感器在生物医学的应用提供了一定的参考。
Abstract
A phase-modulation surface plasmon resonance(SPR) sensor based on Mach-Zehnder configuration is presented and studied. Refractive index information of sample is extracted by phase substraction between the respective interference results of p-polarized and s-polarized light. Compared with the traditional phase-modulation SPR sensors, this design reduces the influence of environment noise and therefore greatly improves resolution. The system can distinguish 0.01° phase difference at least, which is equivalent to 10-5 RIU (refractive index unit). This system is employed to detect the reaction of biological molecules, and a resolution as high as 160 moleculars (IgG) per square microns is obtained. This study provides a certain reference to phase-modulation SPR sensors in application of bio-medical research.
参考文献

[1] K Park, J Ahn, S Y Yi, et al.. SPR imaging-based monitoring of caspase-3 activation[J]. Biochemical and Biophysical Research Communications, 2008, 368(3): 684-689.

[2] T Mori, K Inamori, Y Inoue, et al.. Evaluation of protein kinase activities of cell lysates using peptide microarrays based on surface plasmon resonance imaging[J]. Analytical Biochemistry, 2008, 375(2): 223-231.

[3] A M P B Seneviratne, M Burroughs, E Giralt, et al.. Direct-reversible binding of small molecules to G protein βγ subunits[J]. Biochimica et Biophysica Acta, 2011, 1814(9): 1210-1218.

[4] R G Hamilton, S S Saini, D MacGlashan. Surface plasmon resonance analysis of free IgE in allergic patients receiving omalizumab(Xolair)[J]. J Immunological Methods, 2012, 383(1-2): 54-59.

[5] 张兵心,陈淑芬,付雷, 等. 一种温控的可调表面等离子体光学器件[J]. 光学学报, 2012, 32(7): 0723005.

    Zhang Bingxin, Chen Shufen, Fu Lei, et al.. A temperature-controlled tunable plasmonic dual-band absorber[J]. Acta Optica Sinica, 2012, 32(7): 0723005.

[6] 李娟,王冰艳,薛文瑞. 基于MIM型表面等离子体光波导的Y形分束器的传输性能研究[J]. 光学学报, 2012, 32(1): 0124002.

    Li Juan, Wang Bingyan, Xue Wenrui. Propagation properties of Y-splitters based on MIM surface plasmonic waveguides[J]. Acta Optica Sinica, 2012, 32(1): 0124002.

[7] X L Yu, D X Wang, Z B Yan. Simulation and analysis of surface plasmon resonance biosensor based on phase detection[J]. Sensors and Actuators B, 2003, 91(1-3): 285-290.

[8] R Naraoka, K Kajikawa. Phase detection of surface plasmon resonance using rotating analyzer method[J]. Sensors and Actuators B, 2005, 107(2): 952-956.

[9] H P Ho, W C Law, S Y Wu, et al.. Phase-sensitive surface plasmon resonance biosensor using the photoelastic modulation technique[J]. Sensors and Actuators B, 2006, 114(1): 80-84.

[10] Y H Huang, H P Ho, S Y Wu, et al.. Detecting phase shifts in surface plasmon resonance: a review[J]. Advances in Optical Technologies, 2012, 2012: 471957.

[11] H P Ho, W W Lam, S Y Wu. Surface plasmon resonance sensor based on the measurement of differential phase[J]. Rev Sci Instrum, 2002, 73(10): 3534-3539.

[12] 刘畅,邹正峰,陈淑芬,等. 基于光盘光栅的表面等离子体共振传感器[J]. 中国激光, 2012, 39(3): 0314001.

    Liu Chang, Zou Zhengfeng, Chen Shufen, et al.. Surface plasmon resonance sensor based on compact disk grating[J]. Chinese J Lasers, 2012, 39(3): 0314001.

[13] 陈强华,罗会甫,王素梅,等. 基于相位测量的角漂移自适应结构表面等离子体共振气体折射率测量系统[J]. 光学学报, 2012, 32(12): 1212003.

    Chen Qianghua, Luo Huifu, Wang Sumei, et al.. Gas refractive index measurement system based on a surface plasmon resonance sensor with self-adaptive structure for angle shift and phase detection[J]. Acta Optica Sinica, 2012, 32(12): 1212003.

[14] E Kretschmann. Die bestimmung optischer konstanten von metallen durch anregung von oberflchenplasmaschwingungen[J]. Z Physik, 1971, 241(4): 313-324.

[15] 马科斯·波恩,埃米尔·沃耳夫. 光学原理,光的传播、干涉和衍射的电磁理论[M]. 北京: 科学出版社, 1978.

    Makos Born, Emir Wolf. Principle of Optics, Eletromagnetic Theory of Propagation, Interference and Diffraction of Light[M]. Beijing: Science Press, 1978.

[16] D Kfer, G Witte, P Cyganik, et al.. A comprehensive study of self-assembled monolayers of anthracenethiol on gold: solvent effects, structure, and stability[J]. J Am Chem Soc, 2006, 128(5): 1723-1732.

[17] F S Damos, R Luz, L T Kubota. Electrochemical properties of self-assembled monolayer based on mono-(6-deoxy-6-mercapto)-β-cyclodextrin toward controlled molecular recognition[J]. Electrochimica Acta, 2006, 53(4): 1945-1953.

王弋嘉, 张崇磊, 王蓉, 朱思伟, 袁小聪. 基于马赫-曾德尔结构的相差表面等离子体共振传感器[J]. 中国激光, 2013, 40(7): 0714003. Wang Yijia, Zhang Chonglei, Wang Rong, Zhu Siwei, Yuan Xiaocong. Phase Difference Surface Plasmon Resonance Sensor Based on Mach-Zehnder Configuration[J]. Chinese Journal of Lasers, 2013, 40(7): 0714003.

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