激光与光电子学进展, 2020, 57 (17): 170005, 网络出版: 2020-09-01
光热转换纳米材料在肿瘤光热治疗中的应用 
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Application of Photothermal Conversion Nanomaterials in Tumor Photothermal Therapy
图 & 表
图 1. 金纳米材料的透射电镜图。(a)金纳米笼[11];(b)金纳米棒[12];(c)金纳米簇[13]
Fig. 1. TEM images of Au nanomaterial. (a)Au nanocages[11]; (b) Au nanorods[12]; (c)Au clusters[13]
图 2. 静脉注射SPNS-GSH对小鼠肿瘤进行光热消融[17]。(a)相对肿瘤体积; (b) 存活率曲线
Fig. 2. Photothermal ablation of tumors in mice using intravenously injected SPNS-GSH[17]. (a) Relative tumor volume; (b) mortality free survival curves
图 4. 注射Cu2-xSe溶液后于不同时间点收集的荷瘤小鼠的肿瘤成像图[30]。(a) PA图像,静脉注射; (b) CT图像, 瘤内注射; (c) SPECT图像, 静脉注射
Fig. 4. Images of tumor from a tumor-bearing mouse at different time after injection of Cu2-xSe solution[30]. (a) PA images and I.V. injection; (b) CT images and I.T. injection; (c) SPECT images and I.V. injection
图 5. 分别于静脉和瘤内注射MoS2/DOX后小鼠肿瘤表面的温度变化曲线,以及瘤内和静脉注射MoS2/DOX的荷瘤小鼠的热图像[39]。(a)温度变化曲线;(b)瘤内注射后的热图像;(c)静脉注射后的热图像
Fig. 5. Tumor surface temperature change curves of mice after I.V. and I.T. injection of MoS2/DOX, and thermal images of tumor-bearing mice after I.T. and I.V. injection of MoS2/DOX[39]. (a) Temperature change curves; (b) thermal images after I.T. injection; (c) thermal images after I.V. injection
图 6. 黑磷光热剂的设计制备过程以及光热/化学/基因相结合的靶向肿瘤细胞治疗示意图[50]
Fig. 6. Schematic illustration of the procedure used to fabricate PTA and the combined chemo/gene/photothermal targeted therapy of tumor cells[50]
图 7. 使用脂质体-吲哚菁绿对肿瘤引流淋巴结进行光热治疗[57]。(a)肿瘤周围注射游离或脂质体-吲哚菁绿后腘窝淋巴结的在体NIR荧光成像; (b)腘窝淋巴结表面温度随时间的变化
Fig. 7. Photothermal therapy of tumor-draining lymph nodes using liposomal ICG[57]. (a) In vivo NIR fluorescence imaging of popliteal lymph nodes after peritumoral injection of free or liposomal ICG; (b) popliteal lymph node surface temperatures over time
图 8. 聚合物囊泡修饰的J型和H型构象BODIPY聚集体的治疗示意图[65](应用于660 nm的光动力学疗法或应用于785 nm的光热治疗)
Fig. 8. Schematic illustration of polymeric vesicles with the conformation of both J-type and H-type BODIPY aggregates for either photodynamic therapy under 660 nm or photothermal therapy under 785 nm[65]
图 9. 用于癌症光热治疗的细胞膜伪装下的纳米颗粒(一系列细胞膜涂覆在光热剂表面)[92]
Fig. 9. Cell membrane-camouflaged nanoparticles for cancer photothermal therapy(a series of cell membranes are used to coat onto the surface of photothermal therapeutic agents)[92]
李治, 千维娜, 魏思敏, 闫浩, 靳如意, 郭惠. 光热转换纳米材料在肿瘤光热治疗中的应用[J]. 激光与光电子学进展, 2020, 57(17): 170005. Zhi Li, Weina Qian, Simin Wei, Hao Yan, Ruyi Jin, Hui Guo. Application of Photothermal Conversion Nanomaterials in Tumor Photothermal Therapy[J]. Laser & Optoelectronics Progress, 2020, 57(17): 170005.
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