980 nm/1064 nm双波长半导体激光皮肤焊接

提出将980 nm和1064 nm半导体激光组合应用于皮肤组织伤口焊接，通过肉眼观察、病理学检测以及张力测试等方法对比了双波长激光焊接与传统缝线术的缝合效果。同时，利用热电偶温度测试系统在体测量了激光焊接皮肤切口过程中的组织内部温度，研究激光焊接效果与组织温度之间的关系。结果表明，980 nm和1064 nm激光同时以0.5 W连续输出，功率密度为15.92 W/cm2，每点照射时间为5 s模式组合焊接时，伤口缝合效果与传统缝线术相比具有伤口闭合迅速、愈合快、伤口表面平整、异物反应小、伤口闭合紧等优点。由此可见，双波长激光组织焊接是一种有效的伤口闭合方法，有待进一步研究以便应用于临床。

Abstract

Skin welding with a combination of 1064 nm and 980 nm diode lasers, which′s the first-time discuss in the literature, was performed in this study. The long-time effect of laser skin welding was investigated through macroscopic and microscopic examinations as well as tensile strength tests at different time after the welding, comparing with that of conventional suturing. At the same time, the temperature of rat skin tissue during laser-welding was measured in vivo with a thermo-couple temperature measurement in order to analysis the relation between the effect of tissue welding and tissue temperature. Using a power density of 15.92 W/cm2 with power of 0.5 W in continuous wave mode and exposure time of 5 seconds per spot for both 980 nm and 1064 nm lasers, it′s found that laser tissue welding yielded more effective closure and healing than conventional suturing technique that with faster recovery, better apposition of tissue, less tissue interaction and tighter closure. As a result, tissue welding with a combination of two near-infrared lasers is an effective method for wound closure, and further investigations are in progress for clinical use.

参考文献

[1] G. Godlewski, M. Prudhomme, J. Tang. Applications and mechanisms of laser tissue welding［C］. SPIE, 1996, 2623: 334～341

[2] . S. Bass, M. R. Treat. Laser tissue welding: a comprehensive review of current and future clinical applications[J]. Lasers in Surgery and Medicine, 1995, 17(4): 315-349.

[3] . J. Welch, J. H. Torres, W. F. Cheong. Laser physics and laser tissue interaction[J]. Tex. Heart Inst. J., 1989, 16(3): 141-149.

[4] . Simhon, T. Brosh, M. Halpern et al.. Closure of skin incisions in rabbits by laser soldering II: tensile strength[J]. Lasers Surg. Med., 2004, 35(1): 12-17.

[5] . Cilesiz, S. Thomsen, A. J. Welch et al.. Controlled temperature tissue fusion: HoYAG laser welding of rat intestine in vivo, part two[J]. Lasers Surg. Med., 1997, 21(3): 278-286.

[6] 邹本荣, 刘铜军, 谭毓铨等. 从组织学探讨CO2激光吻合血管的优越性［J］. 中国激光, 1993, A20(8): 636～640

Zou Benrong, Liu Tongjun, Tan Yuquan et al.. Advantages of vascular anastomosis using CO2 laserthrough a histologic examination［J］. Chinese J. Lasers, 1993, A20(8): 636～640

[7] . M. Fried, J. T. Walsh. Laser skin welding: in vivo tensile strength and wound healing results[J]. Lasers Surg. Med., 2000, 27(1): 55-65.

[8] 金晓杰, 周梁, 徐秀玲等. 半导体激光焊接豚鼠面神经的实验研究［J］. 中国激光, 1996, A23(11): 1035～1038

Jin Xiaojie, Zhou Liang, Xu Xiuling et el.. Semiconductor laser repairs of the facial nerve: an experimental study in the guinea pig ENT department［J］. Chinese J. Lasers, 1996, A23(11): 1035～1038

[9] . Gulsoy, Z. Dereli, H. O. Tabakoglu et al.. Closure of skin incisions by 980-nm diode laser welding[J]. Lasers Med. Sci., 2006, 21(1): 5-10.

[10] . O. Tabakoglu, M. Gulsoy. In vivo comparison of near infrared lasers for skin welding[J]. Lasers Med. Sci., 2010, 25(3): 411-421.

[11] 潘振华, 李迎新, 王兴等. 3种剂量弱激光对大鼠皮肤创伤愈合的影响［J］. 中国激光, 2010, 37(2): 599～604

Pan Zhenhua, Li Yingxin, Wang Xing et al.. Effects of low-level laser therapy on cutaneous wound healings with three doses［J］. Chinese J. Lasers, 2010, 37(2): 599～604

[12] 中华人民共和国科学技术部. 关于善待实验动物的指导性意见. 2006-09-30

The Ministry of Science and Technology of the People′s Republic of China. Guidance suggestion of caring laboratory animals. 2006-09-30

[13] . N. Bashkatov, E. A. Genina, V. I. Kochubey et al.. Optical properties of human skin, subcutaneous and mucous tissue in the wavelength range from 400 to 2000 nm[J]. J. Phys. D: Appl. Phys., 2005, 38(2005): 2543-2555.

[14] . Athiraman, R. F. Wolf, K. E. Bartels et al.. Selective photothermal tissue interaction using 805 nm laser and indocyanine green in tissue welding[J]. Journal of X-Ray Science and Technology, 2004, 12(2): 117-126.

[15] . Poppas, Robert B. Stewart, J. Mathieu Massicotte et al.. Temperature-controlled laser photocoagulation of soft tissue: in vivo evaluation using a tissue welding model[J]. Lasers in Surgery and Medicine, 1996, 18(4): 335-344.

胡黎明, 刘云, 芦志华, 王彪, 曹军胜, 李艳华, 高志坚, 秦莉, 王立军. 980 nm/1064 nm双波长半导体激光皮肤焊接[J]. 中国激光, 2011, 38(4): 0404001. Hu Liming, Liu Yun, Lu Zhihua, Wang Biao, Cao Junsheng, Li Yanhua, Gao Zhijian, Qin Li, Wang Lijun. Skin Welding with a Combination of 980 nm and 1064 nm Lasers[J]. Chinese Journal of Lasers, 2011, 38(4): 0404001.

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