目的: 观察克林霉素磷酸酯凝胶联合波长1 565 nm掺铒光纤点阵激光治疗轻中度寻常痤疮的有效性和安全性。方法: 选取2015年1月至2017年9月期间门诊中来就诊的轻中度寻常痤疮患者132例, 随机分成A、B、C三组, A组44人; B组46; C组42人。A组单纯使用点阵激光治疗; B组单纯使用克林霉素磷酸酯外用; C组使用点阵激光治疗联合克林霉素磷酸酯外用。由2名有经验的医生共同进行皮损计数和疗效评价, 同时观察患者的不良反应和复发情况。结果: 三组有效率分别为A组51.6%; B组38.2%; C组79.3%。卡方检验结果显示, C组的总体疗效均优于A组与B组, 差异具统计学意义; 三组均无明显不良反应。结论: 克林霉素磷酸酯凝胶联合波长1 565 nm掺铒光纤点阵激光能有效治疗轻中度寻常痤疮且无明显不良反应, 值得推广。

目的: 观察红蓝光联合药物治疗寻常痤疮的临床疗效和安全性。方法: 将入选的133例寻常痤疮患者随机分成两组, 全部患者予外涂夫西地酸乳膏, 每日早、晚各1次, 并口服小金胶囊1.05 g, 2次/d。另外, 治疗组(69例) 在予以上药物治疗前先洁面并予红蓝光照射15 min, 2次/周。两组患者的疗程均为4周。结果: 治疗4周后, 治疗组有效率为73.9%, 对照组为54.7%, 差异有统计学意义(P＜0.05) 。治疗组4例患者用药后感到轻度皮肤干燥、脱屑、灼热及红斑样反应, 对照组3例出现皮肤干燥及脱屑。但患者均能耐受。差异无统计学意义(P＞0.05)。结论: 红蓝光联合小金胶囊、夫西地酸乳膏治疗寻常痤疮有较好的临床疗效, 且不良反应轻微, 值得临床选用。

目的: 观察中药面膜联合红蓝光治疗仪治疗寻常痤疮临床疗效及安全性。方法: 66例寻常痤疮患者按就诊先后顺序随机分为3组: 对照组、面膜组、联合组, 治疗4周后进行疗效评估, 治疗结束后4周随访复发情况。结果: 联合组及面膜组疗效高于对照组(P<0.05)。结论: 中药面膜联合红蓝光治疗仪治疗寻常痤疮疗效好, 不良反应少, 优于单用疗法, 痤疮后期维持治疗同样值得重视。

In this paper, we studied portable blue and red light-emitting-diode (LED) light sources in phototherapy for mild to moderate acne vulgaris to evaluate the efficacy and tolerance of patients. Patients, randomly divided into blue and red groups, received either blue or red LED phototherapy twice a week for four weeks. After complete treatment, the number of lesions reduced by 71.4% in the blue group, in contrast to 19.5% in the red group. No obvious side effects were observed during and one month after the treatment, except for some mild dryness mentioned by several patients.

Intralesional injection of triamcinolone (TMC) preparations is an effective therapy for cystic acne lesions. However, invasive delivery techniques limit the use of this modality to a relatively narrow class of cases. Skin permeability can be enhanced through creating a lattice of microzones (islets) of light-induced limited thermal damage in the upper layers of epidermis. In this paper, we directly compared safety and efficacy of delivering TMC acetonide with this novel technique versus conventional intralesional injection for treatment of inflammatory acne lesions. A combination of an intense pulsed light system and a specially designed appliqu′e with a pattern of absorbing centers has been used to create the lattice of islets of damage (LID). Quantitative analysis has included estimation of the following parameters: redness, diameter, and height of acne lesions. Clinical photography has been used to document dynamics of lesion development at successive visits (two hours, 24 hours and one week post-treatment). Seven subjects have participated in the study. No difference in lesion dynamics between the treatment and control groups was observed at two-hours follow-up. At 24-hours/one-week follow-ups, TMC-injected and TMC-LID-delivered groups have demonstrated 82%/93% and 80%/89% improvement in height of lesions in comparison to control (60%/68%). Delivery of TMC with the newly proposed LID technique is at least as effective as intralesional injection for treating inflammatory acne lesions. Enhancement of skin permeability using LID approach is a promising technique for accelerating delivery of various compounds to their target areas in the skin.