针对体表组织较厚部位的血管识别困难的问题，提出一种用于体表血管提取与三维成像的双目系统与图像处理算法。成像系统设计采用会聚双目近红外增强相机与近红外LED阵列，并基于朗伯特辐射模型优化了LED阵列的辐照分布均匀性。图像处理算法先通过以Frangi滤波为基础的单目图像处理流程提取左图像中血管骨架，再通过改进的滑窗匹配算法结合右图信息计算血管骨架深度。实验分析了该系统在手背、小臂、颈部以及仿体模型上的血管提取效果、立体匹配有效率以及处理速度，验证了该系统在体表组织较厚部位的实用性。

采用3130XL遗传分析仪系统研究了白纸上的潜血指纹经茚三酮熏显后对于DNA-短串联重复序列(STR)荧光图谱的影响。结果表明: 与对照组(未熏显)相比, 潜血指纹经茚三酮熏显后DNA检出效率有所降低; 经茚三酮熏显后的潜血指纹, 随着潜血指纹浓度的稀释, 能够检出的基因座数逐渐减少。本文对案件现场的证据提取具有重要的指导意义。

视网膜血氧测量技术可以为医学诊断提供可靠的视网膜血氧新陈代谢信息，这些信息可以反映出全身微循环状态。基于光谱法的非侵入性的视网膜血氧饱和度测量是生命科学研究的新热点，国外已开展了大量的研究工作，国内的相关研究还处于起步阶段。为更好地促进视网膜血氧测量在生命科学领域中的研究和应用，对现有的研究成果进行了梳理和回顾。首先介绍了视网膜血氧测量的基本原理，概述了当前已有的视网膜血氧测量技术并讨论了各自的优缺点；然后对现有研究成果和应用情况进行总结，并对视网膜血氧测量存在的若干问题进行讨论；最后对其在生命科学中的研究和发展进行了预测和展望。

为了实现MicroRNA的快速检测, 设计了一种便携式MicroRNA快速检测仪.基于等温滚环扩增技术, 采用光电检测方法, 检测标志物受激发出的荧光光强, 建立特征荧光分析检测系统.通过改变激发光强度、MicroRNA试剂浓度等参量, 验证了该仪器可测量的MicroRNA的浓度范围为0.01~0.1 μmol, 可检测出的最低检出限为7个拷贝数, MicroRNA浓度与荧光信号强度之间为线性关系(R2=0.999 1).

The objective of this study is to demonstrate that tensile stress resulting due to applied force on cornea can be accurately measured by using a time-domain common-path optical coherence tomography (OCT) system with an external contact reference. The unique design of the common-path OCT is utilized to set up an imaging system in which a chicken eye is placed adjacent to a glass plate serving as the external reference plane for the imaging system. As the force is applied to the chicken eye, it presses against the reference glass plate. The modified OCT image obtained is used to calculate the size of contact area, which is then used to derive the tensile stress on the cornea. The drop in signal levels upon contact of reference glass plate with the tissue are extremely sharp because of the sharp decline in reference power levels itself, thus providing us with an accurate measurement of contact area. The experimental results were in good agreement with the numerical predictions. The results of this study might be useful in providing new insights and ideas to improve the precision and safety of currently used ophthalmic surgical techniques. This research outlines a method which could be used to provide high resolution OCT images and a precise feedback of the forces applied to the cornea simultaneously.

We present a novel confocal laser method (CLM) for precise testing of the dioptric power of both positive and negative intraocular lens (IOL) implants. The CLM principle is based on a simple fiber-optic confocal laser design including a single-mode fiber coupler that serves simultaneously as a point light source used for formation of a collimated Gaussian laser beam, and as a highly sensitive confocal point receiver. The CLM approach provides an accurate, repeatable, objective, and fast method for IOL dioptric power measurement over the range from 0 D to greater than +-30 D under both dry and in-situ simulated conditions.