Author Affiliations
Abstract
1 College of Electronic Information and Control Engineering, Beijing University of Technology, Beijing 100124, China
2 Medical Image Processing Group, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
We present a sparse Bayesian reconstruction method based on multiple types of a priori information for multispectral bioluminescence tomography (BLT). In the Bayesian approach, five kinds of a priori information are incorporated, reducing the ill-posedness of BLT. Specifically, source sparsity characteristic is considered to promote reconstruction results. Considering the computational burden in the multispectral case, a series of strategies is adopted to improve computational efficiency, such as optimal permissible source region strategy and node model of the finite element method. The performance of the proposed algorithm is validated by a heterogeneous three-dimensional (3D) micron scale computed tomography atlas and a mouse-shaped phantom. Reconstructed results demonstrate the feasibility and effectiveness of the proposed algorithm.
自发荧光断层成像 稀疏性 贝耶斯方法 100.3010 Image reconstruction techniques 100.3190 Inverse problems 170.3010 Image reconstruction techniques 170.6960 Tomography Chinese Optics Letters
2010, 8(10): 1010
Author Affiliations
Abstract
1 Life Science Research Center, School of Electronic Engineering, Xidian University, Xi'an 710071, China
2 Medical Image Processing Group, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
To avoid the ill-posedness in the inverse problem of bioluminescence tomography, a moment searching algorithm fusing the finite element method (FEM) with the moment concept in theoretical mechanics is developed. In the algorithm, the source's information is mapped to the surface photon flux density by FEM, and the source's position is modified with the feedback through the algorithm of barycenter searching, which makes full use of the position information of the photon flux density on surface. The position is modified in every iterative step and will finally converge to the real source's value theoretically.
分子影像 自发荧光断层成像 矩搜索算法 170.3880 Medical and biological imaging 170.3890 Medical optics instrumentation 170.3660 Light propagation in tissues 000.1430 Biology and medicine Chinese Optics Letters
2009, 7(7): 07614