激光生物学报, 2011, 20 (5): 575, 网络出版: 2015-10-08
应激的光生物调节作用
Photobiomodulation on Stress
摘要
功能内稳态(function-specific homeostasis, FSH)是维持生物功能充分稳定发挥的负反馈机制,FSH的品质由功能复杂性和稳定性构成。应激打破FSH,处于应激内稳态(stress-specific homeostasis, StSH)的应激称为成功应激, 后者能够实现FSH的升级或降级。低水平激光或单色光(low level laser irradiation or monochromatic light, LLL)不能调节成功应激或处于FSH的功能, 但可以促进应激建立StSH。应激能提高组蛋白去乙酰化酶1(sirtuin 1, SIRT1)的活性, LLL则可以调节SIRT1的活性。本文分别针对软骨细胞增殖、延迟性肌肉酸痛、伤口愈合、生长和衰老讨论了LLL的应激效应。
Abstract
Function-specific homeostasis (FSH) is a negative-feedback response of a biosystem to maintain the function-specific fluctuations inside the biosystem so that the function is perfectly performed. The quality of a FSH includes function complexity and performance stability. A stress disrupts a FSH. A stress in stress-specific homeostasis (StSH) is called a successful stress which upgrades or degrades a FSH. Low level laser irradiation or monochromatic light (LLL) can not modulate a successful stress or a function in its FSH, but can promote a stress to establish its StSH. A stress can increase sirtuin 1 (SIRT1) activity, and LLL can further modulate SIRT1 activity. The LLL effects on stress were discussed for chondrocyte proliferation, delayed onset muscle soreness, wound healing, growth and aging.
韦恩秀, 刘承宜, 李方晖, 朱玲, 刘颂豪. 应激的光生物调节作用[J]. 激光生物学报, 2011, 20(5): 575. WEI Enxiu, LIU Chengyi, LI Fanghui, ZHU Ling, LIU Songhao. Photobiomodulation on Stress[J]. Acta Laser Biology Sinica, 2011, 20(5): 575.