中国激光, 2018, 45 (2): 0207019, 网络出版: 2018-02-28
光学相干层析技术在血管流场检测方面的研究进展 
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Research Progress on Optical Coherence Tomography in Detecting Vascular Flow Field
图 & 表
图 1. (a)毛细管中血流流速分布;(b)视网膜血流流速分布
Fig. 1. (a) Flow rate of blood in a capillary tube; (b) flow rate of blood in retinal blood vessel
图 2. 手指皮肤图像。(a)(d)结构图;(b)(e)多普勒偏移流速图;(c)(f)多普勒方差图
Fig. 2. Tomographic images of a left upper extremity Port-wine stain. (a)(d) Structural images; (b)(e) Doppler- shift images; (c)(f) Doppler variance images
图 3. 小鼠脑部OCT活体成像。(a)结构图;(b)相位消抖前的PRDV图;(c)相位消抖前的PRCD图; (d) IBDV图;(e)相位消抖后的PRDV图;(f)相位消抖后的PRCD图
Fig. 3. In vivo OCT imaging of mouse's brain. (a) Structural image; (b) PRDV image without bulk phase removal; (c) PRCD image without bulk phase removal; (d) IBDV image; (e) PRDV image with bulk phase removal; (f) PRCD image with bulk phase removal
图 4. 小鼠表皮血管造影图像。(a)实验小鼠图像;(b)显微镜图像;(c)荧光共焦图像;(d)散斑方差法血管造影图像
Fig. 4. Angiography images of mouse's skin. (a) Image of tested mouse; (b) microscopy image; (c) fluorescence confocal image; (d) angiography image by speckle variance
图 5. SSADA流程图。(a)带通滤波器降低光谱宽度的示意图;(b)分频降低分辨率后提高信噪比的流程图
Fig. 5. Flow charts of SSADA. (a) Schematic of band-pass filtering to reduce spectrum width; (b) schematic of using SSADA to improve average signal to noise ratio
图 6. 视神经乳头OCT成像。(a)结构图;(b) SSADA图;(c)去掉脉络膜层的SSADA图
Fig. 6. OCT images of optic nerve head in eye. (a) Structural image; (b) SSADA image; (c) SSADA image after removing choroid
图 7. 成年小鼠脑部OCT活体成像。(a)采集到的干涉信号集;(b)分布在不同平面的组织图像;(c)血流注图像
Fig. 7. In vivo optical angiography of an adult mouse's brain. (a) Interference signal; (b) imaging result obtained from (a) by optical angiography; (c) fused final optical angiography image of the slice showing the location of moving blood
图 9. 小鼠大脑血管造影图。(a) OMAG;(b) DOMAG
Fig. 9. Angiography images of mouse's brain. (a) OMAG; (b) DOMAG
图 10. 利用平面镜进行相位校正的示意图。(a)样品臂引入参考平面镜产生校准信号的实验装置;(b)包含有校准平面镜的成像信号图(可提取平面镜位置的相位作为整体相位基准)
Fig. 10. Phase correction with mirror. (a) The implementation of a calibration mirror used to generate a calibration signal; (b) a representative A-line showing the signal from the sample (tissue) and the calibration signal
图 11. (a) OCT干涉信号与MZI干涉信号以及对应的波长;(b) MZI干涉信号的解缠相位曲线;(c) k-空间均匀的MZI干涉信号;(d)校正后的解缠相位曲线;(e)完全对齐后的干涉信号
Fig. 11. Schematic representation of the phase-stabilization algorithm. (a) Two A-lines and their MZI signals plotted as a function of sample number. Thecolorbar shows the wavenumber distribution; (b) the unwrapped local phase of the MZI signals as a function of sample number; (c) the MZI signals plotted as a function of the unwrapped local phase; (d) unwrapped phase curves as a function of sample number after correction for shifts as measured by cross-correlation (red curve shifted down compared to (b))
图 12. (a)(b)视神经乳头相位校正前后的结构图;(c)(d)相应相位校正前后的相位分辨多普勒流速图
Fig. 12. (a)(b) Structural images of optic nerve head before and after phase correction; (c)(d) phase-resolved Doppler images before and after phase correction
图 13. 小鼠脑部高灵敏度微血管造影。(a)二维血管造影截面图;(b)三维血管造影图正面视角
Fig. 13. High sensitivity microangiography of mouse' s brain. (a) Sectional view of two-dimensional angiography; (b) front view of three-dimensional angiography
图 14. 通过回缝扫描获取特定时间间隔的图像。(a)振镜电压和对应结构图;(b)第一次扫描重构出的结构图;(c)第二次扫描重构出的结构图
Fig. 14. Example of the backstitched B-scan (in blue) that is used for inter-B-scan phase resolved optical frequency domain imaging. (a) Image of obtaining specific time intervals by B-scan; (b) structural image obtained from the first B-scan; (c) structural image obtained from the second B-scan
图 15. 不同时间间隔视网膜黄斑区域(2.1 mm×2.1 mm)处的血管造影图
Fig. 15. Angiography images of macular area (2.1mm×2.1 mm) of retina with different time intervals
图 16. (a)人眼视网膜OCT结构图;(b)相位分辨多普勒流速图;(c)图(b)红线处相位差分布直方图;(d)每条A-line总相位累计;(e)去抖后的相位分辨多普勒流速图
Fig. 16. (a) In-vivo OCT structure and (b) PRODTphase-resolved ODT images without bulk-motion correction of human retina; (c) histogram of the phase difference distribution for the A-line indicated by the red vertical line in (b); (d) accumulated bulk-motion phase of all the A-lines; (e) PRODT images with bulk-motion correction
高峰, 樊金宇, 孔文, 史国华. 光学相干层析技术在血管流场检测方面的研究进展[J]. 中国激光, 2018, 45(2): 0207019. Gao Feng, Fan Jinyu, Kong Wen, Shi Guohua. Research Progress on Optical Coherence Tomography in Detecting Vascular Flow Field[J]. Chinese Journal of Lasers, 2018, 45(2): 0207019.
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