中国激光, 2018, 45 (2): 0207008, 网络出版: 2018-02-28
肿瘤微环境响应的智能纳米载体在肿瘤光动力治疗中的应用 
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Tumor-Microenvironment Activable Smart Nanocarrier System for Photodynamic Therapy of Cancers
图 & 表
图 1. (a)通过两亲性二肽或氨基酸调节的自组装制备光敏纳米颗粒;(b)通过尾静脉注射FCNPs和游离Ce6(相当于每千克FCNs中含有4.0 mg Ce6)的MCF7-荷瘤裸鼠在不同时间的全身荧光图像,黑色圆圈表示肿瘤部位;(c)测量肿瘤生长20 d的大小(每组小鼠数量n=4)
Fig. 1. (a) Fabrication of photosensitive nanoparticles by amphiphilic dipeptide- or amino-acid- tuned self-assembly; (b) whole body fluorescence images of MCF7-tumor-bearing nude mice intravenously injected through a tail vein with FCNPs and free Ce6 (equivalent to 4.0 mg Ce6 per kilogram FCNs) at different times, black circles indicate tumor sites; (c) measured tumor size for 20 days growth (the number of mice in each group n=4)
图 2. 用于光动力治疗的ALA准聚轮烷前药胶束示意图
Fig. 2. Schematic of ALA pseudopolyrotaxane prodrug micelles for photodynamic therapy
图 3. (a)通过二硫化物重新桥接和生物偶联合成试剂6(叠氮双砜);(b) SST的功能化以获得Ru-SST缀合物8(Ru-SST8)
Fig. 3. (a) Synthesis of the disulfide rebridging and bioconjugation reagent 6 (azide double sulfone); (b) functionalization of SST to receive Ru-SST conjugate 8 (Ru-SST8)
图 4. 使用酶活化的光敏剂-金纳米棒共轭物(MMP2P-GNR)荧光成像和光动力疗法的概念图
Fig. 4. A concept of enzyme activatable fluorescence imaging and photodynamic therapy using a photosensitizer-conjugated gold nanorod (MMP2P-GNR)
图 5. APMECR@MB NCs逐步组装的简化过程及其协同光动力治疗/光热治疗作用的机制
Fig. 5. Simplified representation of a stepwise assembly process of final APMECR@MB NCs and the synergistic PDT/PTT mechanism of their action
图 6. TMB示意图。(a)封闭和开放式TMB的FRET模式;(b)发夹DNA序列和每个FRET对的分离距离
Fig. 6. Schematic of TMB. (a) FRET mode of TMB in the closed and opened forms; (b) hairpin DNA sequence and the separation distance of each FRET pair
图 7. 用于巨噬细胞靶向荧光成像和光动力学治疗的可激活的纳米材料示意图
Fig. 7. A schematic of activatable nano-photo medicine for macrophage-targeted fluorescence imaging and subsequent photodynamic therapy
图 8. Ce6-CPT-UCNPs制备示意图以及光调节的ROS激活Ce6-CPT-UCNPs的原理
Fig. 8. Schematic illustration of the preparation of Ce6-CPT-UCNPs and concept of the light-regulated ROS-activated Ce6-CPT-UCNPs
蓝善优, 张达, 刘小龙, 曾永毅. 肿瘤微环境响应的智能纳米载体在肿瘤光动力治疗中的应用[J]. 中国激光, 2018, 45(2): 0207008. Lan Shanyou, Zhang Da, Liu Xiaolong, Zeng Yongyi. Tumor-Microenvironment Activable Smart Nanocarrier System for Photodynamic Therapy of Cancers[J]. Chinese Journal of Lasers, 2018, 45(2): 0207008.
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