激光与光电子学进展, 2013, 50 (8): 080020, 网络出版: 2013-08-08   

基于表面增强拉曼散射技术的癌症检测研究进展 下载: 997次

Research Progress of Surface Enhanced Raman Spectroscopy for Cancer Detection
作者单位
福建师范大学医学光电科学与技术教育部重点实验室,福建省光子技术重点实验室, 福建 福州 350007
摘要
表面增强拉曼散射(SERS)是一种可从单分子水平对样本进行检测和成像的振动光谱新技术,具有高灵敏度、高特异性、测量快速及对待测样本基本无损等优点,十分适合于癌症的早期筛查研究。近年来,SERS技术应用于癌症检测已成为一个新的研究热点,表现出良好的发展前景。简要介绍了肿瘤组织、肿瘤细胞及癌症患者血液的SERS研究最新成果,对存在的研究难点、局限性及潜在应用价值进行了全面综述,对SERS技术在癌症检测中的发展前景进行了展望。
Abstract
Surface enhanced Raman scattering (SERS) has emerged as a new vibrational spectrum technology for the single-molecule detection and the imaging of samples. It has a great promise in studying the screening of early cancer for its high sensitivity, good specificity and rapidly noninvasive detection. Recently, the application of SERS in cancer detection has been a new research focus. In this review, we provide a brief introduction to the latest research achievements in tumorous tissues, tumorous cells and blood of cancer patients. Then we give a comprehensive discussion of the difficulties, limitations and applications of these works. The prospect of SERS technology for cancer detection is discussed.
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林居强, 阮秋咏, 陈冠楠, 冯尚源, 李步洪, 陈荣. 基于表面增强拉曼散射技术的癌症检测研究进展[J]. 激光与光电子学进展, 2013, 50(8): 080020. Lin Juqiang, Ruan Qiuyong, Chen Guannan, Feng Shangyuan, Li Buhong, Chen Rong. Research Progress of Surface Enhanced Raman Spectroscopy for Cancer Detection[J]. Laser & Optoelectronics Progress, 2013, 50(8): 080020.

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