中药金礞石红外指纹图谱相似度分析

王栋; 王永禄; 郭啸; 王益群; 王伯涛

doi:doi:10.3964/j.issn.1000-0593(2011)10-2715-04

光谱学与光谱分析, 2011, 31 (10): 2715, 网络出版: 2011-11-09

中药金礞石红外指纹图谱相似度分析

Similarity Analysis of FTIR of Lapis Micae Aureum

论文大纲

王栋 ^*王永禄郭啸王益群王伯涛

作者单位

南京工业大学药学院, 江苏南京211816

摘要

分析金礞石红外指纹图谱的相似度, 建立金礞石药材质量的红外指纹图谱评价方法。用傅里叶变换红外光谱仪测定金礞石药材样品的红外光谱, 以共有模式建立金礞石的对照红外指纹图谱, 采用相关系数法和夹角余弦法计算药材样品红外指纹图谱与对照指纹图谱的相似度。 19件样品中, 符合《中国药典》规定者红外指纹图谱与对照指纹图谱的相似度(相关系数法)均在0.94以上, 不符合《中国药典》规定者, 其相似度均在0.94以下; 部分样品虽然来源符合中国药典规定, 但根据传统经验鉴别认为质量较差者, 其相似度值比质量较好者要低些。金礞石的红外指纹图谱可以用于金礞石药材的质量评价, 其相似度值的大小可作为金礞石药材质量的评价指标。

Abstract

Similarity analysis of FTIR of Lapis Micae Aureum was carried out to find out the relationship between similarity of infrared spectra and the quality of medicine samples, and try to provide a new method for its quality assessment. FTIR was used to analyze Lapis Micae Aureum samples. Then 6 samples with good quality were picked up to establish a reference infrared spectra by their infrared spectra. Correlation coefficient method and the included angle cosine method were used to calculate the similarity between sample’s infrared spectra and the reference infrared spectra. For all those 19 samples with characters in accordance with Ch.P, the similarity is above 0.94, and for the others the similarity is less than 0.94. Although some samples’ source meets the requirement of Ch.P, but with poor quality by traditional experience, the similarity is lower than those of good quality. It was concluded that the similarity of infrared spectra of Lapis Micae Aureum is closely related to the quality of medicines. As a result, similarity analysis of FTIR of Lapis Micae Aureum is reliable, and can be used for its quality assessment.

参考文献

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王栋, 王永禄, 郭啸, 王益群, 王伯涛. 中药金礞石红外指纹图谱相似度分析[J]. 光谱学与光谱分析, 2011, 31(10): 2715. WANG Dong, WANG Yong-lu, GUO Xiao, WANG Yi-qun, WANG Bo-tao. Similarity Analysis of FTIR of Lapis Micae Aureum[J]. Spectroscopy and Spectral Analysis, 2011, 31(10): 2715.

中药金礞石红外指纹图谱相似度分析

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