激光生物学报, 2016, 25 (2): 107, 网络出版: 2016-07-26  

雄激素性脱发的发病机制与激光治疗

The Pathogenesis of a Androgenetic Alopecia and Laser Therapy
作者单位
1 华中科技大学医院, 湖北 武汉 430074
2 湖北省体育科学研究所, 湖北 武汉 430205
摘要
雄激素性脱发(androgenetic alopecia, AGA)是皮肤科的常见病与多发病, 雄激素性脱发的药物综合治疗及手术治疗的部分患者取得了一定的效果, 但都存在副作用大、患者依从性差等问题, 有研究表明低功率激光能够促进动物毛发的生长, 因而可能在改善雄激素性脱发的症状方面具有重要的应用前景。本文回顾近年来对雄激素性脱发的可能发病机制、治疗现状及激光治疗的研究情况和进展, 旨在为雄激素性脱发的治疗奠定科学依据。
Abstract
Androgenetic alopecia is a common and frequently-occurring disease in dermatology. It has a positive effects on some patients by the medical comprehensive treatment and surgical treatment. However, it has a negative effect on some other patients because it has a poor treatment compliance. Studies have shown that low power laser could promote the growth of animal hair, which may have crucial application perspective. The purpose of this paper is to review the studies of the progress of possible reasons and treatments on androgenetic alopecia and the progress of laser therapy in recent years, and to have a further study based on these.
参考文献

[1] NORWOOD O T. Male pattern baldness: classification and incidence [J]. South Med J, 1975, 68(11):1359-1365.

[2] 赵辨. 中国临床皮肤病学 [M].南京: 江苏科学技术出版社, 2010: 1185-1186.

    ZHAO Bian. China clinical dermatology [M]. Nanjing: Jiangsu Science and Technology Publishing House, 2010: 1185-1186.

[3] 刘燕, 张可洲, 杨希川. 雄激素性秃发致病机制及诊疗研究进展 [J].中国美容医学, 2013, 22(9):1819-1822.

    LIU Yan, ZHANG Kezhou, YANG Xichuan. Research advance of pathogenesis, diagnosis and treatment of androgenetic alopecia [J]. Chinese Joumal of Aesthetic Medicine, 2013. 22(9):1819-1822.

[4] 廖金凤, 段西凌. 雄激素性脱发的病因病机 [J]. 临床合理用药, 2013, 5(6):174-176

    LIAO Jinfeng, DUAN Xiling . Pathogenesis of androgenetic alopecia [J].Chinese Journal of Clinical Rational Drug Use, 2013, 5(6):174-176.

[5] 张建中. 中国雄激素性秃发诊疗指南 [J]. 临床皮肤科杂志, 2014, 43(3):182-186.

    ZHANG Jianzhong. Guideline for diagnosis and treatment of androgenetic alopecia [J]. J Clin Dermatol, 2014, 43(3):182-186.

[6] MILLAR S E. Molecular mechanisms regulating hair follicle development [J]. Invest Dermatol, 2002, 118(2):216-225.

[7] 褚小燕, 范卫新, 许文嵘. 雄激素受体RNA干扰质粒的构建及其对毛乳头细胞雄激素受体表达的抑制作用研究 [J]. 临床皮肤科杂志, 2009, 38(5):283-286.

    CHU Xiaoyan, FAN Weixin, XU Wenrong. Construction of RNA interference plasmid targeting to androgen receptor gene and its effects on expression of androgen receptor in human dermal papilla cell [J]. J Clin Dermatol, 2009, 38(5):283-286.

[8] 庄晓晟, 范卫新. 雄激素性秃发发病机制分子水平的研究进展 [J]. 临床皮肤科杂志, 2012, 41(7):446-447.

    ZHUANG Xiaosheng, FAN Weixin. The progress in molecular mechanism of androgenic alopecia [J]. J Clin Dermatol, 2012, 41(7):446-447.

[9] 范卫新. 雄激素性脱发的发病机理和治疗进展 [J]. 临床皮肤科杂志, 2001, 30(6):401-403.

    FAN Weixin. Pathogenesis of androgenetic and therapeutic progress [J]. J Clin Dermatol, 2001, 30(6):401-403.

[10] HILLMER A M, FLAQUER A, HANNERKEN S, et al. Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26 [J]. America Journal of Human Genetics, 2008, 82(3):737-743.

[11] 赵玉萍, 涂平, 杨淑霞, 等. 雄激素受体CAG多态性与男性型脱发的关系 [J]. 中国皮肤性病学杂志, 2007, 11(21): 654-656.

    ZHAO Yuping, TU Ping, YANG Shuxia, et al. The relationship of androgen receptor CAG polymorphism and male pattern baldness [J]. Chin J Dem Venereol, 2007, 11(21):654-656.

[12] 郭金竹, 李邻峰. 雄激素性秃发治疗进展 [J]. 实用皮肤病学杂志, 2012, 5(6): 347-350.

    GUO Jinzhu, LI Linfeng. The therapeutic progress of androgenetic alopecia [J]. Journal of Practical Dematology, 2012, 5(6):347-350.

[13] LI Z J, CHOI H I. Autologous platelet-rich plasma:a potential therapeutic tool for promoting hair growth [J]. Dermatol Surg, 2012, 38(7):1040-1046.

[14] KWON O S, HAN J H, YOO H G, et al. Human hair growth enhancement in vito by green tea epigallocatechin-3-gallate (EGCG) [J]. Phytomedicine, 2007, 14(7-8):551-555.

[15] 王光斌, 段西凌. 雄激素性脱发治疗进展 [J]. 临床合理用药, 2014, 7(4):180-181.

    WANG Guangbin, DUAN Xiling. Treatment advance of androgenetic alopecia [J]. Chin J Clinical Drug Use, 2014, 7(4):180-181.

[16] MESTER E, SZENDEB, GRTNER P. The effect of laser beams on the growth of hair in mice [J]. Radiobiol Radiother (Berl), 1968, 9:621-626.

[17] MORENO-ARIAS G, CASTELO-BRANCO C, FERRANDO J. Paradoxical effect after IPL photoepilation [J]. Dermatol Surg, 2002, 28:1013-1016.

[18] SATINO J L, MARKOU M.Hair regrowth and increased hair tensilestrength using the HairMax LaserComb for low-level lasertherapy [J]. Int J Cosmet Surg Aesthetic Dermatol, 2003, 5(2):113-117.

[19] MUNCK A, GAVAZZONI M F, TREB R M .Use of low-level laser therapy as mono- therapy or concomitant therapy for male and female androgenetic alopecia [J]. Int J Trichology, 2014, 6(2):45-49.

[20] KIM H, CHOI J W, KIM J Y, et al. Low-level light therapy for androgenetic alopecia:a 24-week, randomized, double-blind, sham device-controlled multicenter trial [J]. Dermatol Surg, 2013, 39(8):1177-1183.

[21] MAFRA DE LIMA F, VILLAVERDE A B, SALGADO M A, et al. Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat [J]. J Photochem Photobiol B, 2010, 101(3):271-278.

[22] JIMENEZ J J, WIKRAMANAYAKE T C, BERGFELD W, et al. Efficacy and safety of a Low- level laser device in the treatment of male and female pattern hair loss:A multi- center, randomized, sham device-controlled, double-blind Study [J]. American Journal of Clinical Dermatology, 2014, 15(2):115-127.

[23] METELITSA A I, GREEN J B. Home-use laser and light devices for the skin:an update [J]. Semin Cutan Med Surg, 2011, 30(3):144-147.

[24] LEAVITT M, CHARLES G, HEYMAN E, et al. HairMax laserComb laser phototherapy device in the treatment of male androgenetic alopecia:A randomized, double-blind, sham device- controlled, multicentre trial [J]. Clin Drug Investig, 2009, 29:283-292.

[25] 吴之伍, 韩庄. He-Ne激光局部照射治疗脂溢性脱发 [J]. 中国激光医学杂志, 1998, 7(4):245.

    WU Zhiwu, HAN Zhuan. He-Ne laser local irradiation in the treatment of seborrheic alopecia[J]. Chinese Journal of Laser Medicine and Surgery, 1998, 7(4):245.

[26] 范晓红, 李正佳, 李迎春, 等.低能量激光治疗脱发及其相互作用机理研究 [J]. 中国激光, 2004, 31(z1):302-304.

    FAN Xiaohong, LI Zhengjia, LI Yingchun, et al. Low energy treatment of hair loss and its interaction mechanism research [J]. Chinese Journal of Lasers, 2004, 31(z1):302-304.

[27] 罗奇桓. 物化作用对大鼠毛发生长的影响 [D]. 武汉: 华中科技大学, 2008.

    LUO Qihuan. Effect of physical and chemical treatment on hair growth of rat [D]. Wuhan:Huazhong University of Science and Technology, 2008.

[28] 叶超然, 冉崇福, 李硕超, 等. 超激光照射疗法治疗斑秃的临床疗效观察 [J]. 中华物理医学与康复杂志, 2014, 36(9):734-735.

    YE Chaoran, RAN Chongfu, LI Shuochao, et al. Super laser irradiation therapy for the clinical effect of the treatment of alopecia areata [J]. Chinese Journal of Physical and Rehabilitation, 2014, 36(9):734-735.

[29] AL-MUTAIRI N. 308 nm excimer laser for the treatment of alopecia areata [J]. Dermatol Surg, 2007, 33(12):1483-1487.

[30] 王磊, 范卫新, 曹蕾, 等. 脱发患者生活质量调查 [J]. 临床皮肤科杂志, 2008, 37(7):417-419.

    WANG Lei, FAN Weixin, CAO Lei, et al. The life quality of patients with alopecia [J]. J Clin Dermatol, 2008, 37(7):417-419.

[31] 楼玮, 杨勤萍. 脱发患者心理、精神和生活质量状况的初步研究 [J].中国麻风皮肤病杂志, 2011, 27(3):219-220.

    LOU Wei, YANG Qinping. Preliminary study of patients with alopecia about psychological and mental status and quality of life [J]. Clin J Lepr Skin DIS, 2011, 27(3):219-220.

李盛, 黄茜, 陈敏. 雄激素性脱发的发病机制与激光治疗[J]. 激光生物学报, 2016, 25(2): 107. LI Sheng, HUANG Qian, CHEN Min. The Pathogenesis of a Androgenetic Alopecia and Laser Therapy[J]. Acta Laser Biology Sinica, 2016, 25(2): 107.

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