光纤隐失波生化传感研究进展

赵旭东; 许银生; 章向华; 赵修建

doi:doi:10.3788/LOP202158.0300005

激光与光电子学进展, 2021, 58 (3): 0300005, 网络出版: 2021-03-12

光纤隐失波生化传感研究进展下载： 646次

Research Advancements in Optical Fiber Evanescent Wave Biochemical Sensing

赵旭东 ¹许银生 ^1,2章向华 ¹赵修建 ¹

作者单位

¹ 武汉理工大学硅酸盐建筑材料国家重点实验室，湖北武汉 430070

² 华南理工大学发光材料与器件国家重点实验室，广东广州 510640

图 & 表

图 1. 光纤结构分类：锥形光纤、U形光纤、微结构光纤和D形光纤

Fig. 1. Fiber structure type: tapered fiber, U-shaped fiber, microstructure fiber, D-shaped fiber

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图 2. 光纤隐失波传感

Fig. 2. Optical fiber evanescent wave sensing

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图 3. 检测DENVⅡ E蛋白的锥形光纤传感器的干涉谱红移特性。(a)未经PMMA表面功能化时^[15]；(b)经PMMA表面功能化后^[16]

Fig. 3. Red shift of interference spectrum for a functionalized tapered optical fiber sensor used to detect Dengue E protein. (a) Without PMMA surface functionalization^[15]; (b) with PMMA surface functionalization^[16]

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图 4. 核酸功能化光纤探针^[22]。 (a)基于三明治式组装的Ade检测策略的原理图；(b)Ade校准曲线

Fig. 4. Nucleic acid functionalized fiber optic probes^[22]. (a) Schematic illustration of the sandwich-type assembly based Ade detection strategy; (b)calibration curve of Ade

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图 5. 制备传感器特性实验装置示意图^[30]

Fig. 5. Schematic diagram of experimental setup used to characterize fabricated sensor^[30]

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图 6. 基于Fe₂O₃涂层的微结构光纤传感器^[32]。(a) Fe₂O₃包覆微结构光纤气敏原理示意图；(b)多芯光纤的截面图

Fig. 6. Fe₂O₃ nanotube coating micro-fiber interferometer^[32]. (a) Diagrammatic sketch of gas sensing principle for the Fe₂O₃ coated MFI; (b) sectional view for the multi-core fiber

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图 7. 图7中红外分子指纹区^[38]

Fig. 7. MIR molecular fingerprint region^[38]

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图 8. 硫系红外光纤隐失波生化传感。(a)喂养（实纤）和饥饿（虚线）小鼠肝脏的FEWS谱^[41]；(b)TAS光纤记录人肺细胞红外光谱^[37]

Fig. 8. Evanescent wave biochemical sensing of chalcogenide fibers. (a) FEWS spectra of fed (solid line) and starved (dashed line) mice liver^[41]; (b) human lung cell infrared spectra recorded with the TAS glass fiber^[37]

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图 9. 法国DIAFIR公司产品：TAS光纤隐失波传感器^[42]

Fig. 9. DIAFIR company’s product in France: TAS fiber evanescent wave sensor^[42]

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图 10. 聚合物涂层光纤传感^[44]。(a)聚合物涂层光纤传感器隐失波光谱法的一般测量原理；(b)涂层和未涂层硫系锥形光纤对二甲苯水溶液的红外吸收光谱

Fig. 10. Polymer-coated fiber sensor^[44]. (a)General measurement principle of EWS of the polymer-coated fiber sensor；(b)IR absorption spectra of six concentrations of the p-xylene aqueous solution recorded by coated and uncoated ChG-TF

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图 11. 扫描电镜图片^[14]。(a)具有不同脉冲能量的孔；(b)具有24 mW脉冲能量的孔；(c)孔阵列通道；(d)线性通道；(e)不同CH₄浓度下的光谱响应；(f) 吸收峰强度与CH₄浓度的函数

Fig. 11. SEM picture^[14]. (a) Holes with different pulse energy; (b) hole with 24 mW pulse energy; (c) hole-array channels; (d) linear channels; (e) measured spectral responses at different CH₄ concentrations; (f) absorption peak intensity as a function of CH₄ concentration

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表 1石英光纤生物化学传感研究概括

Table1. Research summary of silica fiber biochemical sensing

Analyte	Coating	Detection limit	Linear concentration range	Sensitivity	Response time /s	Reference
Dengue virus	3-aminopropyltriethoxysilane Dengue virus antibody	0.1 μg·L^-1	0.1‒1 μg·L^-1	7×10^-6 pg·mL^-1	≤2 min	Ref. [17]
Red blood cell	P-doped graphene		0‒104 mg·L^-1	>10⁶pm·mg^-1·L^-1	<50 s	Ref. [20]
Procalcitonin	Gold nanoparticles Procalcitonin antibody	95 fg·mL^-1	0.0001‒100 ng·mL^-1		≤15 min	Ref. [21]
Adenosine	DNA	25 mmol·L^-1	50‒3.5 mmol·L^-1		<300 s	Ref. [22]
Methylene blue			2‒50 μmol·L^-1		≤16 min	Ref. [25]
Fe³⁺	Carbon dot	0.77 μg·L^-1	0‒300 μg·L^-1	0.0061 nm·μg^-1·L^-1	≤4 min	Ref. [28]
Cd²⁺	Propylene thiourea	44.8 μg·L^-1	0‒13440 μg·L^-1			Ref. [29]
pH	ZnO micro-flower hydrogel	Acid： 2.59 nm·pH^-1 Alkali： 0.70 nm·pH^-1	pH：3‒11		≤10 s	Ref. [30]
Ammonia	PDMDAAC Sodium pyrophosphate	0.5 mg·L^-1	0.5‒50 mg·L^-1		<3 min	Ref. [33]
CH₂O	ZnO nanorod	1.6 μg·L^-1	0‒0.18 mg·L^-1	9.78 dBm·mg^-1·L^-1	200 s	Ref. [34]

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表 2中红外生物化学光纤传感器研究概括

Table2. Research summary of MIR biochemical optical fiber sensor

Fiber type	Transmission range /μm	Attenuation /(dB·m^-1)	Analyte	Characteristic peak /μm	Concentration range	Response time /s	Reference
Ge₂₀Ga₅Sb₁₀S₆₅（MoS₂）			Malignant tumor tissue		10^-9‒10^-10 RIU		Ref. [39]
As₄₀S₆₀ （Graphene）			Hemoglobin	1	18 μg·dL^-1		Ref. [40]
Ge-As-Se-Te （Polydopamine）	2.5‒16	0.57@6.52 μm	P-xylene	6.6	50 μg·mL^-1	<600	Ref. [44]
Ge₂₆As₁₇Se₂₅Te₃₂	2‒10	0.3‒1@5.2‒9.3 μm	CH₃CH₂OH	7.87‒8.33 8.92‒10	0‒20%(mole fraction) 0‒50% (mole fraction)		Ref. [45]
Ge₂₆As₁₇Se₂₅Te₃₂	5‒9		CH₃COCH₃	7.33 8.18	1%(mole fraction)		Ref. [47]
Ge₂₀Se₆₀Te₂₀	2.5‒15	3.4@5.9 μm	CH₃OH CH₂Cl₂	9.78 7.9			Ref. [49]
GaGeSbS	3‒5		CHCl₃	4.16			Ref. [50]
Ge₂₆As₁₇Se₂₅Te₃₂	5.5‒8.5	<1	Antigenic additive	7.83	0‒1%(volume raction)		Ref. [52]
As₂S₃	3‒10	1	CH₄	3.32	>10^-4	<20	Ref. [14]
Ge-Te-AgI	8‒13.5	<10	CO₂	4.25 15			Ref. [38]

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赵旭东, 许银生, 章向华, 赵修建. 光纤隐失波生化传感研究进展[J]. 激光与光电子学进展, 2021, 58(3): 0300005. Zhao Xudong, Xu Yinsheng, Zhang Xianghua, Zhao Xiujian. Research Advancements in Optical Fiber Evanescent Wave Biochemical Sensing[J]. Laser & Optoelectronics Progress, 2021, 58(3): 0300005.

光纤隐失波生化传感研究进展下载： 646次

图 1. 光纤结构分类：锥形光纤、U形光纤、微结构光纤和D形光纤

Fig. 1. Fiber structure type: tapered fiber, U-shaped fiber, microstructure fiber, D-shaped fiber

图 2. 光纤隐失波传感

Fig. 2. Optical fiber evanescent wave sensing

图 3. 检测DENVⅡ E蛋白的锥形光纤传感器的干涉谱红移特性。(a)未经PMMA表面功能化时^[15]；(b)经PMMA表面功能化后^[16]

Fig. 3. Red shift of interference spectrum for a functionalized tapered optical fiber sensor used to detect Dengue E protein. (a) Without PMMA surface functionalization^[15]; (b) with PMMA surface functionalization^[16]

图 4. 核酸功能化光纤探针^[22]。 (a)基于三明治式组装的Ade检测策略的原理图；(b)Ade校准曲线

Fig. 4. Nucleic acid functionalized fiber optic probes^[22]. (a) Schematic illustration of the sandwich-type assembly based Ade detection strategy; (b)calibration curve of Ade

图 5. 制备传感器特性实验装置示意图^[30]

Fig. 5. Schematic diagram of experimental setup used to characterize fabricated sensor^[30]

图 6. 基于Fe₂O₃涂层的微结构光纤传感器^[32]。(a) Fe₂O₃包覆微结构光纤气敏原理示意图；(b)多芯光纤的截面图

Fig. 6. Fe₂O₃ nanotube coating micro-fiber interferometer^[32]. (a) Diagrammatic sketch of gas sensing principle for the Fe₂O₃ coated MFI; (b) sectional view for the multi-core fiber

图 7. 图7中红外分子指纹区^[38]

Fig. 7. MIR molecular fingerprint region^[38]

图 8. 硫系红外光纤隐失波生化传感。(a)喂养（实纤）和饥饿（虚线）小鼠肝脏的FEWS谱^[41]；(b)TAS光纤记录人肺细胞红外光谱^[37]

Fig. 8. Evanescent wave biochemical sensing of chalcogenide fibers. (a) FEWS spectra of fed (solid line) and starved (dashed line) mice liver^[41]; (b) human lung cell infrared spectra recorded with the TAS glass fiber^[37]

图 9. 法国DIAFIR公司产品：TAS光纤隐失波传感器^[42]

Fig. 9. DIAFIR company’s product in France: TAS fiber evanescent wave sensor^[42]

图 10. 聚合物涂层光纤传感^[44]。(a)聚合物涂层光纤传感器隐失波光谱法的一般测量原理；(b)涂层和未涂层硫系锥形光纤对二甲苯水溶液的红外吸收光谱

Fig. 10. Polymer-coated fiber sensor^[44]. (a)General measurement principle of EWS of the polymer-coated fiber sensor；(b)IR absorption spectra of six concentrations of the p-xylene aqueous solution recorded by coated and uncoated ChG-TF

图 11. 扫描电镜图片^[14]。(a)具有不同脉冲能量的孔；(b)具有24 mW脉冲能量的孔；(c)孔阵列通道；(d)线性通道；(e)不同CH₄浓度下的光谱响应；(f) 吸收峰强度与CH₄浓度的函数

Fig. 11. SEM picture^[14]. (a) Holes with different pulse energy; (b) hole with 24 mW pulse energy; (c) hole-array channels; (d) linear channels; (e) measured spectral responses at different CH₄ concentrations; (f) absorption peak intensity as a function of CH₄ concentration

表 1石英光纤生物化学传感研究概括

Table1. Research summary of silica fiber biochemical sensing

表 2中红外生物化学光纤传感器研究概括

Table2. Research summary of MIR biochemical optical fiber sensor

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光纤隐失波生化传感研究进展 下载： 646次

图 1. 光纤结构分类：锥形光纤、U形光纤、微结构光纤和D形光纤

Fig. 1. Fiber structure type: tapered fiber, U-shaped fiber, microstructure fiber, D-shaped fiber

图 2. 光纤隐失波传感

Fig. 2. Optical fiber evanescent wave sensing

图 3. 检测DENVⅡ E蛋白的锥形光纤传感器的干涉谱红移特性。(a)未经PMMA表面功能化时[15]；(b)经PMMA表面功能化后[16]

Fig. 3. Red shift of interference spectrum for a functionalized tapered optical fiber sensor used to detect Dengue E protein. (a) Without PMMA surface functionalization[15]; (b) with PMMA surface functionalization[16]

图 4. 核酸功能化光纤探针[22]。 (a)基于三明治式组装的Ade检测策略的原理图；(b)Ade校准曲线

Fig. 4. Nucleic acid functionalized fiber optic probes[22]. (a) Schematic illustration of the sandwich-type assembly based Ade detection strategy; (b)calibration curve of Ade

图 5. 制备传感器特性实验装置示意图[30]

Fig. 5. Schematic diagram of experimental setup used to characterize fabricated sensor[30]

图 6. 基于Fe2O3涂层的微结构光纤传感器[32]。(a) Fe2O3包覆微结构光纤气敏原理示意图；(b)多芯光纤的截面图

Fig. 6. Fe2O3 nanotube coating micro-fiber interferometer[32]. (a) Diagrammatic sketch of gas sensing principle for the Fe2O3 coated MFI; (b) sectional view for the multi-core fiber

图 7. 图7中红外分子指纹区[38]

Fig. 7. MIR molecular fingerprint region[38]

图 8. 硫系红外光纤隐失波生化传感。(a)喂养（实纤）和饥饿（虚线）小鼠肝脏的FEWS谱[41]；(b)TAS光纤记录人肺细胞红外光谱[37]

Fig. 8. Evanescent wave biochemical sensing of chalcogenide fibers. (a) FEWS spectra of fed (solid line) and starved (dashed line) mice liver[41]; (b) human lung cell infrared spectra recorded with the TAS glass fiber[37]

图 9. 法国DIAFIR公司产品：TAS光纤隐失波传感器[42]

Fig. 9. DIAFIR company’s product in France: TAS fiber evanescent wave sensor[42]

图 10. 聚合物涂层光纤传感[44]。(a)聚合物涂层光纤传感器隐失波光谱法的一般测量原理；(b)涂层和未涂层硫系锥形光纤对二甲苯水溶液的红外吸收光谱

Fig. 10. Polymer-coated fiber sensor[44]. (a)General measurement principle of EWS of the polymer-coated fiber sensor；(b)IR absorption spectra of six concentrations of the p-xylene aqueous solution recorded by coated and uncoated ChG-TF

图 11. 扫描电镜图片[14]。(a)具有不同脉冲能量的孔；(b)具有24 mW脉冲能量的孔；(c)孔阵列通道；(d)线性通道；(e)不同CH4浓度下的光谱响应；(f) 吸收峰强度与CH4浓度的函数

Fig. 11. SEM picture[14]. (a) Holes with different pulse energy; (b) hole with 24 mW pulse energy; (c) hole-array channels; (d) linear channels; (e) measured spectral responses at different CH4 concentrations; (f) absorption peak intensity as a function of CH4 concentration

表 1石英光纤生物化学传感研究概括

Table1. Research summary of silica fiber biochemical sensing

表 2中红外生物化学光纤传感器研究概括

Table2. Research summary of MIR biochemical optical fiber sensor

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图 3. 检测DENVⅡ E蛋白的锥形光纤传感器的干涉谱红移特性。(a)未经PMMA表面功能化时^[15]；(b)经PMMA表面功能化后^[16]

Fig. 3. Red shift of interference spectrum for a functionalized tapered optical fiber sensor used to detect Dengue E protein. (a) Without PMMA surface functionalization^[15]; (b) with PMMA surface functionalization^[16]

图 4. 核酸功能化光纤探针^[22]。 (a)基于三明治式组装的Ade检测策略的原理图；(b)Ade校准曲线

Fig. 4. Nucleic acid functionalized fiber optic probes^[22]. (a) Schematic illustration of the sandwich-type assembly based Ade detection strategy; (b)calibration curve of Ade

图 5. 制备传感器特性实验装置示意图^[30]

Fig. 5. Schematic diagram of experimental setup used to characterize fabricated sensor^[30]

图 6. 基于Fe₂O₃涂层的微结构光纤传感器^[32]。(a) Fe₂O₃包覆微结构光纤气敏原理示意图；(b)多芯光纤的截面图

Fig. 6. Fe₂O₃ nanotube coating micro-fiber interferometer^[32]. (a) Diagrammatic sketch of gas sensing principle for the Fe₂O₃ coated MFI; (b) sectional view for the multi-core fiber

图 7. 图7中红外分子指纹区^[38]

Fig. 7. MIR molecular fingerprint region^[38]

图 8. 硫系红外光纤隐失波生化传感。(a)喂养（实纤）和饥饿（虚线）小鼠肝脏的FEWS谱^[41]；(b)TAS光纤记录人肺细胞红外光谱^[37]

Fig. 8. Evanescent wave biochemical sensing of chalcogenide fibers. (a) FEWS spectra of fed (solid line) and starved (dashed line) mice liver^[41]; (b) human lung cell infrared spectra recorded with the TAS glass fiber^[37]

图 9. 法国DIAFIR公司产品：TAS光纤隐失波传感器^[42]

Fig. 9. DIAFIR company’s product in France: TAS fiber evanescent wave sensor^[42]

图 10. 聚合物涂层光纤传感^[44]。(a)聚合物涂层光纤传感器隐失波光谱法的一般测量原理；(b)涂层和未涂层硫系锥形光纤对二甲苯水溶液的红外吸收光谱

Fig. 10. Polymer-coated fiber sensor^[44]. (a)General measurement principle of EWS of the polymer-coated fiber sensor；(b)IR absorption spectra of six concentrations of the p-xylene aqueous solution recorded by coated and uncoated ChG-TF

图 11. 扫描电镜图片^[14]。(a)具有不同脉冲能量的孔；(b)具有24 mW脉冲能量的孔；(c)孔阵列通道；(d)线性通道；(e)不同CH₄浓度下的光谱响应；(f) 吸收峰强度与CH₄浓度的函数

Fig. 11. SEM picture^[14]. (a) Holes with different pulse energy; (b) hole with 24 mW pulse energy; (c) hole-array channels; (d) linear channels; (e) measured spectral responses at different CH₄ concentrations; (f) absorption peak intensity as a function of CH₄ concentration