Traditional moxibustion therapy can stimulate heat and blood-vessel expansion and advance blood circulation. In the present study, a novel noncontact-type thermal therapeutic system was developed using a near-infrared laser diode. The device allows direct interaction of infrared laser light with the skin, thereby facilitating a controlled temperature distribution on the skin and the deep tissues below the skin. While using a tissue-mimicking phantom as a substitute for real skin, the most important optical and thermal parameters are the absorption/attenuation coe±cient, thermal conductivity, and specific heat. We found that these parameters can be manipulated by varying the agar-gel concentration. Hence, a multilayer tissue-mimicking phantom was fabricated using different agar-gel concentrations. Thermal imaging and thermocouples were used to measure the temperature distribution inside the phantom during laser irradiation. The temperature increased with the increase in the agar-gel concentration and reached a maximum value under the tissue phantom surface. To induce a similar thermal effect of moxibustion therapy, controlled laser-irradiation parameters such as output power, wavelength and pulse width were obtained from further analysis of the temperature distribution. From the known optothermal properties of the patient's skin, the temperature distribution inside the tissue was manipulated by optimizing the laser parameters. This study can contribute to patient-specific thermal therapy in clinics.

针对微波连续加热造成生物组织温升过高而损伤正常组织，提出计算机编码的脉冲调制微波辐照生物组织，有效控制加热区域内的温度分布.采用红外热成像的方式观察分层仿生体模中各层的温度分布，分析讨论脉冲调制微波占空比、频率和功率对生物组织加热区域内温度分布的影响.结果表明，采用提高脉冲调制微波占空比和功率或在一定范围内改变调制脉冲频率的方式来提高生物组织加热区域内的热效应.该方法将为肿瘤微波热疗提供新的有效加热方式和途径.

对描述激光辐照生物组织光热响应的经典生物热传递模型和生物热波模型进行比较,分析两种模型的适用条件及影响因素。结果表明,当激光辐照时间接近或小于生物组织热释放时间时,基于生物热波模型的结果与经典生物热传导模型的结果差异明显,采用后者对热损伤进行评估引起的误差较大。对于生物热波模型,考察点所在深度越浅,非傅里叶导热特征越明显。比较两种生物热传导模型,第一层血液灌注率和吸收系数对辐射原点的瞬态温度分布均有影响,但不改变其热特征。