细胞内镜需实现最大倍率约500倍的连续放大成像，受光纤照明及杂散光的影响，其图像存在不均匀光照，且光照分布会随放大倍率的变化而变化。这会影响医生对病灶的观察及判断。为此，本文提出一种基于细胞内镜光照模型的图像不均匀光照校正算法。根据图像信息由光照分量和反射分量组成这一基础，该算法通过卷积神经网络学习图像的光照分量，并基于二维Gamma函数实现不均匀光照校正。实验表明，经本文方法进行不均匀光照校正后，图像的光照分量平均梯度和离散熵分别为0.22和7.89，优于自适应直方图均衡化、同态滤波和单尺度Retinex等传统方法以及基于深度学习的WSI-FCN算法。

Cytoendoscopy requires continuous amplification with a maximum magnification rate of about 500 times. Due to optical fiber illumination and stray light, the image has non-uniform illumination that changes with the magnification rate, which affects the observation and judgement of lesions by doctors. Therefore, we propose an image non-uniform illumination correction algorithm based on the illumination model of cytoendoscopy. According to the principle that image information is composed of illumination and reflection components, the algorithm obtains the illumination component of the image through a convolutional neural network, and realizes non-uniform illumination correction based on the two-dimensional Gamma function. Experiments show that the average gradient of the illumination channel and the discrete entropy of the image are 0.22 and 7.89, respectively, after the non-uniform illumination correction by the proposed method, which is superior to the traditional methods such as adaptive histogram equalization, homophobic filtering, single-scale Retinex and the WSI-FCN algorithm based on deep learning.