激光与光电子学进展, 2024, 61 (1): 0117001, 网络出版: 2024-02-06  

医用柔性CO2激光传输介质研究进展与展望创刊六十周年特邀

Research Progress and Perspective of Clinically Promising Flexible CO2 Laser Delivery Mediums
陶光明 1,2,3,*邹郁祁 1,2,3刘超 1,2,3任志禾 1,2,3
作者单位
1 华中科技大学武汉光电国家研究中心,湖北 武汉 430074
2 华中科技大学同济医院血管衰老教育部重点实验室,湖北 武汉 430074
3 华中科技大学材料科学与工程学院材料成型与模具技术国家重点实验室,湖北 武汉 430074
摘要
中红外激光凭借其非接触、高效率和高精准度的显著优势,广泛应用于病变组织切除、组织整形和肿瘤间质光热疗法等临床外科手术中。在诸多中红外激光中,二氧化碳(CO2)激光具备极高消融效率和高精准度的特点,广泛应用于皮肤、耳鼻喉和腹腔等手术中。然而,由于缺乏稳定、高性能的小尺度柔性能量传输介质,CO2激光无法像钬激光、钕激光等近红外激光一样,通过成熟的石英光纤,以微创或无创的方式进入体内,在人体内部自然腔道中进行微创介入操作。目前CO2激光通常通过导光臂、空心波导管等传输介质进行手术,这极大地制约了其优势在微创手术中的充分体现。为使CO2激光更好地服务于临床外科医疗领域,本文总结了现有的医用CO2激光能量传输介质,重点讨论了热拉式多材料光纤技术在CO2激光医疗领域的研究进展,并展望了未来多功能柔性CO2激光消融机器人光纤的发展趋势及应用前景。
Abstract
Mid-infrared (MIR) lasers offer substantial benefits, including non-contact operation, high efficiency, and precision, making them widely utilized in clinical surgical procedures such as lesion tissue removal, tissue plasticity, and tumor interstitial photothermal therapy. Notably, carbon dioxide (CO2) lasers, among various MIR lasers, are extensively employed in skin, ear, nose, throat, and abdominal surgeries due to their exceptionally high ablation efficiency and precision. However, the lack of stable and high-performance small-scale, flexible laser energy-delivering mediums for CO2 lasers restricts their use in minimally invasive or noninvasive procedures, a capability present in mature silica fibers used in holmium, neodymium, and other near-infrared lasers for conducting minimally invasive interventional operations in natural cavities in vivo. Presently, CO2 laser procedures typically rely on energy-delivering mediums such as articulated arms and hollow waveguides but this considerably hampers the application of CO2 laser in minimally invasive surgeries. To enhance the role of CO2 lasers in clinical medicine, we review and summarize existing medical CO2 laser energy-delivering mediums, focusing on the advances in thermal-drawn multi-material fiber technology in CO2 laser surgery, and explore future development trends and applications of multifunctional flexible CO2 laser ablation robotic fibers.

陶光明, 邹郁祁, 刘超, 任志禾. 医用柔性CO2激光传输介质研究进展与展望[J]. 激光与光电子学进展, 2024, 61(1): 0117001. Guangming Tao, Yuqi Zou, Chao Liu, Zhihe Ren. Research Progress and Perspective of Clinically Promising Flexible CO2 Laser Delivery Mediums[J]. Laser & Optoelectronics Progress, 2024, 61(1): 0117001.

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