近年来光学相干层析成像（OCT）作为“光学活检”手段在临床上得到了快速发展与应用。在与造影剂结合后，还可以获得分子活动信息。但是单一模式的OCT技术存在穿透深度低等不足，多模态成像技术可以弥补这一短板，同时还可以充分发挥OCT的技术优势，从多层面获取生物体的综合信息。综述了目前造影剂用于OCT与荧光成像、光声成像、磁共振成像耦合的多模态成像进展，以及多模态造影剂未来的发展趋势。

Recently optical coherence tomography (OCT) has obtained a fast development and application in clinic due to its "optical biopsy" properties. In addition, OCT could also provide molecular information after using contrast agents. However, single modal OCT technique has its disadvantages, such as poor penetration depth. These can be avoided by multi-modal imaging technique, which will also help to make full use of OCT system and to get a full understanding of organism from different aspect. In this review, we summarized the development of multi-modal contrast agents for OCT, fluorescence imaging, photoacoustic imaging and magnetic resonance imaging, and discussed the future of multi-modal contrast agents.