激光生物学报, 2020, 29 (6): 489, 网络出版: 2021-02-05  

lncRNA调控肺癌及以 lncRNA为靶点的中药抗肺癌治疗的研究进展

Research Progress in the Regulation of Lung Cancer by lncRNA and the Anti-lung Cancer Treatment by Chinese Medicine Targeting lncRNA
李小娜 1,2,3李开瑞 1,2,3宋岚 1
作者单位
1 湖南中医药大学医学院,长沙 410208
2 中医药防治眼耳鼻咽喉疾病湖南省重点实验室,长沙 410208
3 湖南省中医药防治眼耳鼻咽喉疾病与视功能保护工程技术研究中心,长沙 410208
摘要
长链非编码 RNA(lncRNA)是指长度大于 200 bp的非编码 RNA。在肺癌发生发展的过程中有大量 ln-cRNA的表达发生异常变化,这些 lncRNA主要通过调控肺癌细胞的增殖、凋亡、迁移、自噬等方面影响肺癌的病理生理过程。近些年,以 lncRNA为靶点的中药抗肺癌研究逐渐增多,本文主要就肺癌中异常表达的 lncRNA及其作用机制进行了综述,并概述了以 lncRNA为靶点的抗肺癌中药治疗进展,以期为肺癌的治疗和研究提供新方法和新思路。
Abstract
Long non-coding RNA (lncRNA) are a group of non-coding RNA that consist of more than 200 nucleotides. A re-view of the literature indicates that a large amount of lncRNA expression changes abnormally during the development of lung cancer. These lncRNA mainly affect the pathophysiological process of lung cancer by regulating the proliferation, apoptosis, migration, and autophagy of lung cancer cells. Recently, research on anti-lung cancer of traditional Chinese medicine targeting lncRNA is increasing. This article mainly reviews the abnormal expression of lncRNA and its mechanism of lncRNA action and summarizes the research progress of lung cancer treatment through traditional Chinese medicine with lncRNA as therapeutic tar-get, be expecting to provide new methods and new ideas for the treatment and research of lung cancer.
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李小娜, 李开瑞, 宋岚. lncRNA调控肺癌及以 lncRNA为靶点的中药抗肺癌治疗的研究进展[J]. 激光生物学报, 2020, 29(6): 489. 李小娜, 李开瑞, 宋岚. Research Progress in the Regulation of Lung Cancer by lncRNA and the Anti-lung Cancer Treatment by Chinese Medicine Targeting lncRNA[J]. Acta Laser Biology Sinica, 2020, 29(6): 489.

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