Scattered light imaging through complex turbid media has significant applications in biomedical and optical research. For the past decade, various approaches have been proposed for rapidly reconstructing full-color, depth-extended images by introducing point spread functions (PSFs). However, because most of these methods consider memory effects (MEs), the PSFs have angular shift invariance over certain ranges of angles. This assumption is valid for only thin turbid media and hinders broader applications of these technologies in thick media. Furthermore, the time-variant characteristics of scattering media determine that the PSF acquisition and image reconstruction times must be less than the speckle decorrelation time, which is usually difficult to achieve. We demonstrate that image reconstruction methods can be applied to time-variant thick turbid media. Using the time-variant characteristics, the PSFs in dynamic turbid media within certain time intervals are recorded, and ergodic scattering regimes are achieved and combined as ensemble point spread functions (ePSFs). The ePSF traverses shift-invariant regions in the turbid media and retrieves objects beyond the ME. Furthermore, our theory and experimental results verify that our approach is applicable to thick turbid media with thickness of 1 cm at visible incident wavelengths.

A method is proposed to optimize the recording structure of the photorefractive volume grating to compensate high spatial frequency in the distorted wavefront by optical phase conjugation. Based on the coupled-wave equation, the diffraction efficiency of the recorded grating formed by the scattered beams in different recording structures is simulated. The theoretical results show that the recorded modulations with high spatial frequency can be significantly improved in the small recording angle. In the experiment, three recording structures with the recording angles of 7.5°, 30°, and 45° are chosen to verify the compensation effect. Compared with the reconstructed image in the large recording angle of 45°, the signal to noise ratio of the image recorded at 7.5° increases to 3.2 times of that at 45°.

Blood oxygenation and flow are both important parameters in a living body. In this Letter, we introduce a simple configuration to simultaneously measure blood flow and oxygenation using an off-the-shelf spectrometer. With the integration time of 10 ms, flow phantom measurements, a liquid blood phantom test, and an arm cuff occlusion paradigm were performed to validate the feasibility of the system. We expect this proof-of-concept study would be widely adopted by other researchers for acquiring both blood flow and oxygenation changes due to its straightforward configuration and the possibility of multimodal measurement.

Traditional one-way imaging methods become invalid when a target object is completely hidden behind scattering media. In this case, it has been much more challenging, since the light wave is distorted twice. To solve this problem, we propose an imaging method, so-called round-trip imaging, based on the optical transmission matrix of the scattering medium. We show that the object can be recovered directly from the distorted output wave, where no scanning is required during the imaging process. We predict that this method might improve the imaging speed and have potential application for real-time imaging.