β-磷酸三钙(β-TCP)具有生物降解性和生物相容性, 但其固有的脆性限制了其在承重种植体中的应用。为进一步提高β-TCP的力学性能和生物相容性, 本研究以纳米黏土(Nano clay, NC)为添加剂, 采用数字光处理(Digital light processing, DLP)技术制备了β-TCP/NC(TNC)复合支架, 支架TNC10多孔结构孔径为200~300 μm。当加入NC含量为10%(质量分数)时, 支架(TNC10)各结构特征的烧结收缩最小。加入NC不会改变TCP的物相成分, 且支架表面均匀分布Si、Mg元素。加入NC可以提高TCP支架的压缩强度, NC(粒径<500 nm)融合在TCP颗粒的间隙中, 对比纯TCP支架, TNC10支架的压缩强度提高了10%。另外, TNC10 组较纯TCP的比表面积增加2倍以上。TNC降解速率更快, 可以持续释放Ca、Mg、Si、Li等离子, 并且TNC降解液保持弱碱性的环境。研究结果表明: 加入NC对β-TCP支架的力学强度、降解性能均具有一定的促进作用。利用DLP方法打印的具有良好的理化性能的多孔生物陶瓷支架在骨修复领域有巨大应用前景。

β-tricalcium phosphate (β-TCP) has biodegradability and biocompatibility, but its inherent brittleness limits its application in load-bearing implants. In order to further improve the mechanical property and biocompatibility of β-TCP, β-TCP/NC (TNC) composite scaffold with nano clay (NC) as additive and the porous structure of the scaffold has a pore size of 200-300 μm was prepared by digital light processing (DLP) technique. When the content of NC is 10% (in mass), the sintering shrinkage of each structural feature of the support (TNC10) is the smallest. Addition of NC does not change the phase composition of TCP, and Si and Mg elements are evenly distributed on the surface of the scaffold. Addition of NC can improve the compression strength of TCP scaffolds. NC (particle size < 500 nm) is fused in the gap of TCP particles. Compared with pure TCP scaffolds, the compression strength of TNC10 is increased by 10%. In addition, the specific surface area of TNC10 group was more than 2 times higher than that of pure TCP. TNC degradation rate is faster while Ca²⁺, Mg²⁺, Si⁴⁺, and Li²⁺ can be continuously released, which maintains a weakly alkaline environment. The results demonstrate that the addition of NC has a certain promotion effect on the mechanical strength, degradation performance β-TCP scaffolds. Porous bioceramic scaffolds with good physical, chemical property by DLP method have great application prospects in the field of bone repair.