1 南通市口腔医院,江苏 南通 226000
2 南通市中西医结合医院,江苏 南通 226000
3 北京大学长三角光电科学研究院,江苏 南通 226000
4 人工微结构和介观物理国家重点实验室,北京大学物理学院,北京 100871
与可见光区(400~700 nm)和近红外一区(NIR-I,700~900 nm)荧光成像(FL)相比,近红外二区(NIR-II,1000~1700 nm)荧光成像具有更深的穿透深度、更高的信噪比。开发亮度高、吸收/发射波长长、生物相容性好的NIR-II荧光探针一直是NIR-II荧光成像领域的一个重要研究方向。有机NIR-II荧光探针以其优异的生物相容性和良好的药代动力学特性而备受关注。本文从红移吸收/发射波长、提高荧光量子产率/摩尔吸光系数、改善生物相容性等角度系统总结了近年来花菁类染料、D-A-D小分子、聚合物点等有机NIR-II荧光探针的研究进展,重点介绍了具有代表性的荧光探针在活体NIR-II荧光成像中的应用,最后讨论了有机NIR-II荧光探针迈向临床应用面临的潜在挑战。
医用光学 近红外二区 荧光探针 花菁类染料 有机小分子 聚集诱导发光 共轭聚合物 中国激光
2023, 50(21): 2107101
北京航空航天大学仪器科学与光电工程学院,北京 100191
随着光子材料和光子器件在可穿戴技术、智慧医疗、仿生机器人等新兴应用领域的不断拓展,研制具有优异机械柔韧性、生物相容性甚至生物可降解性的光子器件日益重要。为同时实现优异的光学性能和生物力学性能,柔性光子器件从材料合成、结构设计、功能实现到工艺制备等诸多方面亟需探索。其中,有机聚合物因其质地轻柔、生物相容性好、合成可控、结构功能易于改性等优势,被认为是制备柔性光子器件最具竞争力的材料之一。一系列新型的功能性有机光子器件,如光波导、衍射光栅、光子晶体等被相继被报道。本文综述了近年来柔性有机聚合物光子器件的研究进展,总结和分析了现有技术、方法和应用,并对未来的挑战和前景进行了讨论和展望。
柔性光子器件 有机聚合物 生物医学光子学 光学传感 光诊断与治疗 激光与光电子学进展
2023, 60(13): 1316002
1 南开大学药物化学生物学国家重点实验室,天津 300071
2 南开大学化学学院高分子化学研究所,天津 300071
3 南开大学功能高分子材料教育部重点实验室,天津 300071
弹热制冷是一种新型制冷技术,具有解决目前传统制冷剂制冷和蒸汽压缩制冷技术所存在的大部分问题的巨大应用潜力,被认为是最具发展前景的制冷技术之一。它具有环保、高效、节能的优点,在成本、制冷量和效率及可行性等方面具有可观的优势。但弹热器件在形变过程中占用空间大、材料使用寿命低,在实际应用中仍然需要不断改进,因此,实现更加高效环保的固态制冷技术依旧是一个巨大的挑战。本综述归纳整理了弹热材料的原理、种类和器件设计。首先介绍弹热效应的基本原理和表征方法;其次,归纳以镍钛基、铜基、铁基、铁磁体形状记忆合金以及弹性聚合物作为弹热材料实现固态制冷的研究进展和需要解决的问题;最后,对目前研制出的弹热制冷装置进行了归纳分析和讨论。
材料 聚合物 弹热效应 固态制冷 形状记忆合金 激光与光电子学进展
2023, 60(13): 1316014
Author Affiliations
Abstract
1 Nanjing University, College of Engineering and Applied Sciences, National Laboratory of Solid State Microstructures, Key Laboratory of Intelligent Optical Sensing and Manipulation, Nanjing, China
2 Nanhui Institute of Intelligent Optical Sensing and Manipulation, Nanjing, China
3 China Academy of Space Technology, National Key Laboratory of Science and Technology on Space Microwave, Xi’an, China
4 Beihang University, School of Instrumentation and Optoelectronic Engineering, Beijing, China
The explosive growth of information urgently requires extending the capacity of optical communication and information processing. Orbital-angular-momentum-based mode division multiplexing (MDM) is recognized as the most promising technique to improve the bandwidth of a single fiber. To make it compatible with the dominant wavelength division multiplexing (WDM), broadband equal high-efficient phase encoding is highly pursued. Here, we propose a twisted-liquid-crystal and rear-mirror-based design for ultrabroadband reflective planar optics. The backtracking of the light inside the twisted birefringent medium leads to an achromatic phase modulation. With this design, a single-twisted reflective q-plate is demonstrated to convert a white beam to a polychromatic optical vortex. Jones calculus and vector beam characterization are carried out to analyze the broadband phase compensation. A dual-twisted configuration further extends the working band to over 600 nm. It supplies an ultrabroadband and reflective solution for the WDM/MDM-compatible elements and may significantly promote advances in ultrabroadband planar optics.
liquid crystal polymers optical vortex geometric phase ultrabroadband Advanced Photonics Nexus
2023, 2(2): 026009
Author Affiliations
Abstract
Department of Chemistry, Hacettepe University, Ankara 06800, Turkey
Sulfamethoxazole (SMX) is a sulfonamide antibiotic primarily used to treat urinary tract infections and used in veterinary and industrialized husbandry to treat diseases and food additives. Like other antibiotics, SMX is considered as a pollutant in water and food that threaten local life. This study developed a surface plasmon resonance (SPR) sensor chip that is fast, highly selective, and reusable, and requires no pretreatment for detecting SMX. As a receptor, SMX imprinted methacrylic acid-2-hydroxyethyl methacrylate-ethylene glycol dimethacrylate polymer [poly(MAA-HEMA-EGDMA)] was used. The surface of the gold SPR chips was coated with a drop-casting method. The nanofilm coated chips were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), ellipsometer, contact angle measurement, and Fourier-transform infrared spectrometry (FTIR). Imprinting factor (IF) was calculated as: ΔR[MIP(molecularly imprinted polymers)]/ΔR[NIP(non-imprinted)]=12/3.5=3.4. Limit of detection (LOD) and limit of quantification (LOQ) values were calculated with 3 s/m and 10 s/m methods, and the results were found to be 0.001 1 μg/L for LOD 0.003 4 μg/L for LOQ. Adsorption studies on both standard SMX solution and commercial milk samples were applied. Also, we investigated the developed chip’s reusability, storability, and selectivity with amoxicillin and cefalexin.
Antibiotic sulfamethoxazole nanofilm chip molecularly imprinted polymers (MIP) surface plasmon resonance (SPR) Photonic Sensors
2022, 12(4): 220417
1 南京理工大学材料科学与工程学院 新型显示材料与器件工信部重点实验室, 江苏 南京 210094
2 北京化工大学化学工程学院 有机⁃无机复合材料国家重点实验室, 北京 100029
3 电磁环境效应与光电工程国家级重点实验室, 江苏 南京 210094
卤化物钙钛矿(ABX3)量子点及其发光器件具有色纯度高、外量子效率高以及在可见光范围内可调等特点,近年来在照明、显示等领域中展现出巨大潜力。然而,钙钛矿量子点发光二极管(PeQLEDs)的稳定性正成为制约其商业应用的最大障碍,除了钙钛矿发光层本身的稳定性问题之外,传输层的水氧稳定性问题也不可忽略。为了解决这一发展过程中的难题,我们提出了基于氮唑类单体构筑共价有机聚合物材料(COP‐N)替代传统的PEDOT∶PSS作为空穴注入层材料的新型PeQLEDs。我们发现COP‐N具有本征的水氧稳定性,且与PVK之间的空穴注入势垒更小。这些特性使得基于COP?N的PeQLED 在取得比PEDOT∶PSS更好发光效率的同时实现了近2倍的稳定性提升。我们认为,这种共价有机聚合物有望成为新型的空穴注入材料,实现高效稳定的钙钛矿电致发光,促进钙钛矿发光器件的发展。
共价有机聚合物 空穴注入层 钙钛矿量子点 发光二极管 covalent organic polymers hole injection layer perovskite quantum dots light-emitting diodes
Author Affiliations
Abstract
1 Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123 Jiangsu, P. R. China
2 Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, P. R. China
Photoacoustic (PA) imaging with much deeper tissue penetration and better spatial resolution had been widely employed for the prevention and diagnosis of many diseases. In this study, a new type of hydrogen peroxide (H2O-activated photoacoustic nanoprobe [Mn-AH nanoscale coordination polymer nanodots (NCPs)] was successfully synthesized by a simple one-step method in water phase containing 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), horse radish peroxidase (HRP), and manganese ion (Mn. After modification by polyethylene glycol (PEG), Mn-AH NCPs exhibited excellent stability and biocompatibility for in vivo H2O2-responsive chromogenic assay with great specificity and sensitivity. In the presence of H2O2, colorless ABTS would be converted by HRP into the oxidized form with strong near-infrared (NIR) absorbance, enabling photoacoustic detection of endogenous H2O2. Using H2O2-activated Mn-AH NCPs, we have successfully performed PA imaging and H2O2 detection of subcutaneous murine colon CT26 tumor and deep-seated orthotopic bladder tumor. Due to the inherent Mn element existence inside the Mn-AH, this nanoprobe also serves as a good T1-weighted magnetic resonance imaging (MRI) contrast agent simultaneously. Lastly, after accomplishing its imaging functions, the Mn-AH NCPs could be cleared out from the body without any long-term toxicity, providing a new opportunity for cancer diagnosis and treatment.Photoacoustic (PA) imaging with much deeper tissue penetration and better spatial resolution had been widely employed for the prevention and diagnosis of many diseases. In this study, a new type of hydrogen peroxide (H2O-activated photoacoustic nanoprobe [Mn-AH nanoscale coordination polymer nanodots (NCPs)] was successfully synthesized by a simple one-step method in water phase containing 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), horse radish peroxidase (HRP), and manganese ion (Mn. After modification by polyethylene glycol (PEG), Mn-AH NCPs exhibited excellent stability and biocompatibility for in vivo H2O2-responsive chromogenic assay with great specificity and sensitivity. In the presence of H2O2, colorless ABTS would be converted by HRP into the oxidized form with strong near-infrared (NIR) absorbance, enabling photoacoustic detection of endogenous H2O2. Using H2O2-activated Mn-AH NCPs, we have successfully performed PA imaging and H2O2 detection of subcutaneous murine colon CT26 tumor and deep-seated orthotopic bladder tumor. Due to the inherent Mn element existence inside the Mn-AH, this nanoprobe also serves as a good T1-weighted magnetic resonance imaging (MRI) contrast agent simultaneously. Lastly, after accomplishing its imaging functions, the Mn-AH NCPs could be cleared out from the body without any long-term toxicity, providing a new opportunity for cancer diagnosis and treatment.
Nanoscale coordination polymers (NCPs) PA imaging MRI H2O2 detection metabolic nanoprobes Journal of Innovative Optical Health Sciences
2022, 15(5): 2250026