作者单位
摘要
1 南京邮电大学电子与光学工程学院,柔性电子(未来技术)学院,江苏 南京 210023
2 东南大学电子科学与工程学院,江苏 南京 210096
提出一种外泌体检测新方法,通过将表面增强拉曼散射(SERS)纳米探针固定在核酸适体(DNA)功能化水凝胶中,实现对肿瘤源性外泌体的高灵敏度光学检测。SERS纳米探针被用于识别肿瘤源性外泌体并产生指纹光学信号。SERS活性DNA功能化水凝胶(简称“SD水凝胶”)作为传感器,不仅提供了用于生物识别的三维反应位点,而且可放大SERS纳米探针的光学信号。选择性地与靶外泌体结合后,SERS纳米探针脱离SD水凝胶,导致SERS信号减弱,从而实现光学检测。通过SERS信号变化,SD水凝胶可以定量、灵敏地检测肿瘤源性外泌体,浓度检测限(LOD)约为22 μL-1。该SD水凝胶将为临床癌症诊断提供一种新的技术手段。
生物光学 表面增强拉曼散射光谱技术 光学检测 外泌体 纳米探针 水凝胶 
光学学报
2023, 43(21): 2117001
作者单位
摘要
东南大学 电子科学与工程学院 先进光子学中心,南京 210096
采用内、外曲线分别为圆形弯曲和欧拉-圆形弯曲曲线,以及内、外曲线分别为欧拉-圆形弯曲和欧拉弯曲曲线,提出并优化了两种曲率与宽度双渐变的硅基单模弯曲光波导结构。采用有限时域差分对提出的两种弯曲光波导结构进行了仿真优化,并与圆形弯曲、欧拉弯曲、欧拉-圆形弯曲和贝塞尔弯曲光波导的性能进行了比较。结果表明在等效弯曲半径为2 μm时,内、外曲线分别为圆形弯曲和欧拉-圆形弯曲的弯曲光波导损耗值仅为0.005 6 dB/90°,且具有低的损耗波长相关性。
绝缘体上硅 弯曲光波导 曲率渐变 宽度渐变 低损耗 Silicon on insulator Optical waveguide bend Curvature variation Width variation Low bending loss 
光子学报
2023, 52(8): 0823002
作者单位
摘要
东南大学 先进光子学中心, 南京 210096
利用金属有机化学气相沉积方法在蓝宝石衬底上生长了一系列具有双中温AlN插入层(MTGAlN)的半极性AlN薄膜样品。中温生长的AlN插入层具有较大的表面粗糙度,形成了类似纳米级图形化衬底结构,能够有效阻断高温生长的半极性AlN样品中堆垛层错的传播,从而提高半极性AlN样品的表面形貌和晶体质量。通过原子力显微镜和X射线衍射仪的表征,研究了MTGAlN插入层厚度在20~100nm之间的变化对半极性AlN样品的表面形貌和晶体质量的影响。结果表明,所有半极性AlN样品都具有[1122]取向。当插入的MTGAlN中间层厚度约为80nm时,半极性AlN样品表面粗糙度显著降低,晶体质量明显改善。
双中温AlN插入层 半极性AlN 表面形貌 晶体质量 dual moderatetemperaturegrown AlN interlayer semipolar AlN epilayer surface morphology crystalline quality 
半导体光电
2022, 43(3): 505
作者单位
摘要
东南大学 先进光子学中心, 南京 210096
采用金属有机化学气相沉积技术,在半极性蓝宝石衬底上成功生长了具有高电子浓度和良好表面形貌的Si掺杂的非极性a面nAlGaN外延层。深入研究了铟(In)表面活性剂和无掺杂的AlGaN缓冲层对nAlGaN的结构特征和电学性能的影响。表征结果表明,利用In表面活性剂和无掺杂的AlGaN缓冲层,非极性a面nAlGaN外延层的晶体质量的各向异性被有效地抑制,同时显著改善了其表面形貌和电学性能。测得非极性a面nAlGaN的电子浓度及电子迁移率分别为-4.8×1017cm-3和3.42cm2/(V·s)。
非极性a面nAlGaN 表面活性剂 AlGaN缓冲层 电学性能 nonpolar aplane nAlGaN indium surfactant AlGaN buffer layer electrical properties 
半导体光电
2022, 43(3): 461
作者单位
摘要
1 东南大学电子科学与工程学院,江苏 南京 210096
2 中国人民解放军陆军装备部驻无锡地区军事代表室,江苏 无锡 214000
硅基探测器具有稳定可靠、暗电流低、响应度高、价格低廉等优点,被广泛应用于光电探测等领域。针对硅基探测器在紫外波段探测能力有限的问题,设计了一款可增强硅基探测器在紫外波段探测能力的聚光结构。首先,利用ZnCdS∶Mn/ZnS量子点的荧光特性将吸收的紫外光转化为可见光。然后,配合短波通截止滤色膜使探测器在260~400 nm波段的外量子效率均大于20%,响应时间限制在ms量级,暗电流限制在pA量级。实验结果表明,使用量子点层的聚光结构能明显改善硅基探测器在紫外波段的探测能力,通过改变量子点的尺寸还可以在紫外波段实现探测范围可调的硅基探测器。
探测器 外量子效率 掺杂量子点 短波通截止滤色膜 
激光与光电子学进展
2022, 59(17): 1704001
Author Affiliations
Abstract
1 Advanced Photonics Center, Southeast University, Nanjing 210096, China
2 Collaborative Innovation Center of Light Manipulations and Applications, Shandong Normal University, Jinan 250358, China
Photonic structures with topological edge states and resonance loops are both important in optical communication systems, but they are usually two separate structures. In order to obtain a photonic system combining properties from both, we design multiple-layer nested photonic topological structures. The nested topological loops not only have topological protection immune to structural disorder and defects, but also possess both the properties of unidirectional propagation and loop resonance. Through mode analysis and simulations, we find that the transport can form diverse circulation loops. Each loop has its own resonance frequencies and can be solely excited in the nested layered structure through choosing its resonance frequencies. As a result, this work shows great application prospects in the area of reconfigurable photonic circuits.
topological edge states unidirectional propagation loops resonance reconfigurability 
Chinese Optics Letters
2022, 20(6): 061301
Author Affiliations
Abstract
1 Advanced Photonics Center, Southeast University, Nanjing 210096, China
2 Key Laboratory of Optoelectronic Technology of Jiangsu Province, School of Physical Science and Technology, Nanjing Normal University, Nanjing 210023, China
3 School of Physics and Electronics, Central South University, Changsha 410012, China
4 Collaborative Innovation Center of Light Manipulations and Applications, Shandong Normal University, Jinan 250358, China
We investigate femtosecond laser trapping dynamics of two-photon absorbing hollow-core nanoparticles with different volume fractions and two-photon absorption (TPA) coefficients. Numerical simulations show that the hollow-core particles with low and high-volume fractions can easily be trapped and bounced by the tightly focused Gaussian laser pulses, respectively. Further studies show that the hollow-core particles with and without TPA can be identified, because the TPA effect enhances the radiation force, and subsequently the longitudinal force destabilizes the trap by pushing the particle away from the focal point. The results may find direct applications in particle sorting and characterizing the TPA coefficient of single nanoparticles.
laser trapping multiphoton processes ultrafast nonlinear optics 
Chinese Optics Letters
2020, 18(8): 081901
Author Affiliations
Abstract
1 Advanced Photonics Center, Southeast University, Nanjing 210096, China
2 School of Physics and Electronics, Central South University, Changsha 410012, China
Understanding the nonlinear optical effect of novel materials plays a crucial role in the fields of photonics and optoelectronics. Herein, we theoretically and experimentally investigate the simultaneous presence of third-order locally refractive nonlinearity and thermally induced nonlocal nonlinearity saturation. We present analytical expressions for the closed-aperture Z-scan trace and the number of spatial self-phase modulation (SSPM) rings, which allows one to unambiguously and conveniently separate the contributions of local and nonlocal nonlinear refraction in the case that both effects occur simultaneously. As a test, we study both the local and thermally induced nonlocal nonlinear refraction in fullerene/toluene solution by performing continuous-wave Z-scan and SSPM measurements at two different wavelengths. This work enriches the understanding of the physical mechanism of the optical nonlinear refraction effect in solution dispersions of nanomaterials, which can be exploited for nonlinear photonic devices.
190.4420 Nonlinear optics, transverse effects in 190.4870 Photothermal effects 
Chinese Optics Letters
2019, 17(6): 061901
作者单位
摘要
东南大学 先进光子学中心, 江苏 南京 210096
由于微流控芯片具有优异的集成性和灵活的可操作性, 基于芯片上的检测方法被大量开发, 发展十分迅速。其中, 表面增强拉曼光谱(SERS)凭借其超高的灵敏度、独一无二的指纹谱和窄峰宽等特点成为一种广泛采用的检测手段。SERS微流控芯片集SERS检测技术与微流控芯片的优势于一体, 一方面为SERS检测方法的重复性和可靠性提供了一个高效平台, 另一方面推动了微流控芯片的功能拓展, 在生物分子探测、细胞捕获乃至组织模拟等领域具有广阔的应用前景。本文在简要介绍SERS的原理及其生物传感应用的基础上, 重点概述了SERS微流控芯片的构建及其在生物传感及检测中的应用, 最后探讨了该研究方向存在的问题及发展方向。
表面增强拉曼光谱 微流控 微流控芯片 生物传感 surface-enhanced raman spectroscopy microfluidic SERS microfluidic chip biosensing 
中国光学
2018, 11(3): 513
Author Affiliations
Abstract
Advanced Photonics Center, Southeast University, Nanjing 210096, China
Due to the excellent electro-optic properties of lead lanthanum zirconium titanate ((Pb,La)(Zr,Ti)O3, PLZT), compact 1×2 and 1×4 PLZT optical switches with a high response speed are proposed and fabricated successfully in this Letter. By introducing a thin isolating layer between the waveguides and the electrodes, the absorption loss of the fabricated 1×2 PLZT switch caused by the electrodes is reduced 8.9 dB with a relatively low driving voltage. The 1×2 PLZT switch shows an insertion loss of 18.3 dB and crosstalk of 20.5 dB at an applied voltage of 9.5 V. The fabricated 1×4 switch array shows an insertion loss of 20.7 dB and a crosstalk of 20.5 dB at an applied voltage of 13 V. The response time of the switches is less than 27 ns, and the device’s size is only 15 mm×6 mm. The switches can be used in optical communication systems.
060.4510 Optical communications 130.3120 Integrated optics devices 130.3130 Integrated optics materials 130.4815 Optical switching devices 
Chinese Optics Letters
2015, 13(11): 111301

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